Conserved Protein Domain Family
LapC_YejM_PbgA

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NF038282: LapC_YejM_PbgA 
LPS biosynthesis-modulating metalloenzyme YejM
YejM (LapC, PbgA) belongs to a regulatory system that controls the activity of LpxC, the enzyme that catalyzes the first committed step in the LPS synthesis. The earlier report (2015) by Dalebroux, et al (PMID: 25856753), which assigned a role in cardiolipin transport and introduced the name PbgA (phoPQ-barrier gene A), is no longer considered accurate.
Statistics
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PSSM-Id: 468449
Aligned: 26 rows
Threshold Bit Score: 996.422
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_019079958   1 MVTNRQRYREKVSQMISWGHWFALFNILFSLVLGSRYLFVSDWPSSLIGRVYALVSWLGHFSFIVFAAYLLVIFPLTFVV 80  Yersinia entero...
WP_009639384   1 MVTNSQRYREKVSQMVSWGHWFALFNILLSLGLGSRYLFVSDWPSSLEGRIYALVSLLGHFSFVGFAVYLLIIFPLTFVV 80  Serratia sp. M24T3
WP_016942550   1 MVTNRPRYREKVSQMISWGHWFALFNILLALGLGSRYLFVADWPSSLPGRLYSLVSWLGHFSFIGFSTYLLIIFPLTFIV 80  Dickeya
WP_009112289   1 MVTNRQRYREKVSQMISWGHWFALFNILLSLGLGSRYLFVVDWPSSLFGRIYALVSWLGHFSFIGFAAYLLIVFPLTFIV 80  Brenneria
WP_011147092   1 MVTSRQRYREKVSQMISWGHWFALFNILLSLGLGSRYLFVSDWPSSLFGRVYALSSWLGHFSFIVFAAYLLVLFPLTFIA 80  Photorhabdus
WP_012989297   1 MVTSRQHYREKVSQMISWGHWFALFNIMFSLVLGSRYLFASDWPGSLFGRIYALLSWLGHFSFIVFAIYLLILFPLTFIV 80  Xenorhabdus bov...
WP_006704095   1 MVINRQSYREKVSHMISWGHWFTLFNILLGLIIGSRYLFVSNWPDSLLGRIYALASWLGHFSFIIFVVYLLIIFPLTFVI 80  Candidatus Regi...
WP_015874410   1 MLMKRQHYREKLSQMISWGHWFVLFNIFLTLILGSRYLFVSDWPTSLLGRVYALVSWLGHFSFIVFVVYLLTLFPLTFII 80  Candidatus Hami...
WP_004920906   1 MVT-QQRYRDKVSQMISWGHWFALFNILLSLGLSSSYLFIFDWPDTLAGRIFAFVSWIGHFSFVVFACYLLIVFPLTFIV 79  Providencia
WP_012367752   1 MVTRNQSYREKVSQMISWGHWFALFNIILSLLLGSRYLFIADWPSTFAGRLYAIVSWMGHFSFIVFAIYILILFPLTFVV 80  Proteus
WP_019079958  81 MSQRLLRFISAAFATAGLTLLLVDTEVFTRFHLHLNPVVWELVVNPDQTELARDWQLMFIAVPVIFLVEMLFGTWAWQKL 160 Yersinia entero...
WP_009639384  81 MSQRLLRFLSAILATAGLTLLLVDTEVFTRFHLHINPVVWELVVNPGQADLARDWQLMFIAVPIIFLVEMLFGTWAWQKL 160 Serratia sp. M24T3
WP_016942550  81 MSQRLLRFLSAALATAGQTLLIVDAAVFSRFHLHLNMTVWDLVTNPDQSEMVRDWQLLFISVPVIFMVEMLFGTWCWQKL 160 Dickeya
WP_009112289  81 MSQRLLRFLSAALATAGLTLLLVDIEVFTRFHLHLNTTVWELVVNPDQSELARDWQLMFIGIPLIFMVEMLFGTWCWQKL 160 Brenneria
WP_011147092  81 MSQRLLRFLSAIFATAGLTLLIFDIAIYNRFHLHLTPLVWDLVINPDQGELAREWQLMFICIPVIFLIQMLFGTWSWQKL 160 Photorhabdus
WP_012989297  81 MSQRLLRFLSAALATAGLTLLILDSSIYIRFHLHLTPLVWDLVTNPDQGELTREWQLMFICIPAIFLVQMLFGTWSWQKL 160 Xenorhabdus bov...
WP_006704095  81 MSPRCLRFIATVLATAGLMLLSIDTEVFTRFHLHLNPVTWKLMLNLELGKFTAHWLLVSIYVLIIFFLELFLARWCWKKL 160 Candidatus Regi...
WP_015874410  81 FSQRLLRFFSVILATSGLALLIIDGETFTRFHLHITPMIWAFLINPEQTQLSRDWQYLFIVIPIIFSIEMLFSIFCWQKL 160 Candidatus Hami...
WP_004920906  80 MSQRLLRLICVALATVGTTLLLFDIRVFSQFGLHLTPQVWDLVINPDKGEMAREWQLMFITIPIIFLVQMLFATWSWQKL 159 Providencia
WP_012367752  81 VSQRLLRVISCALASAGLTLLIFDIAVYQQFQLHLTQLVWDLVINPDEGEMAREWQLIFIGIPIIFLIEMLFATWSWQKL 160 Proteus
WP_019079958 161 RSLNRQRFVKPLVAVFISAFFASHLIYIWADANFYRPISMQRANLPLSYPMTARKFLEKHGLLDQEEYQRRLIEQGNPDA 240 Yersinia entero...
WP_009639384 161 RSLSRQSFAKPLVAIFICCFIASHLMYIWADANFYRPITMQRSNLPLSYPMTARKFLEKHGLLDAQAYQQRLIEQGDPDA 240 Serratia sp. M24T3
WP_016942550 161 RSLNRRHFARPMAAAFIVAFCLSHLMYIWADANFYRPITMQRANLPLSYPMTARRFLEKHGLLNAQEYERRLALQGNPDA 240 Dickeya
WP_009112289 161 RSLNRRSFGKPLAGVFISAFIASHLMYIWADANFYRPITMQRANLPLSYPMTARRFLEKHGLLDAQEYQRRVAQQGNPEA 240 Brenneria
WP_011147092 161 RSLNRQRFGKPLAAVLISAFLASHLMYIWADANFYRPITMQRSNLPLSYPMTARKFLEKHGLLDQQEYQRRLMQQGDPAA 240 Photorhabdus
WP_012989297 161 RSLNRQRFGKPLAAVFIIAFIASHLMYIWADANFYRSITMQRSNLPLSYPMTARKFLEKHGLLDQQEYQRRMNQQGNPAA 240 Xenorhabdus bov...
WP_006704095 161 RSLDRKHFVKPLVALFICAFFASHLIYSWADANFYRPITMQRANLPLSYPMTARNFLEKQGLLNQQEYQRRLAEQGNPSA 240 Candidatus Regi...
WP_015874410 161 RKFTKKIFVNLLIGLFITAFCTSHILYSWADANFYRPITMQRSNLPLSYPMTARKFLQKHGLLNQQKYEKQLIENDKLNA 240 Candidatus Hami...
WP_004920906 160 RSLNRQTFGKPLAGIFIATFIMSHLMYAWSDANFYRPITMQRYNYPLSQPMTARKLLDKYGLLDLSEHQNRVFQQGSPTA 239 Providencia
WP_012367752 161 RSLNRQRWGKPLACVFISCFILSHSMSIWADANFYRPITMQRANLPLSYPMTARKFLERHGFINQSEYEQRLMSEGNPAA 240 Proteus
WP_019079958 241 LTVEYPLSPIVFSD-NGSGYNLLLIVVDGIRASSLQKDMPALSEFGHANIQFDRHYSSGNRQDTGLFGLFYGISPTYLDG 319 Yersinia entero...
WP_009639384 241 ISVEYPLNSISFRD-KGSNLNLLMIVVGGLNADSVAKDMPQLKQFASTNVNFADHLSSGNKNDTGLFGLFYGISPTYLEG 319 Serratia sp. M24T3
WP_016942550 241 VSVEYPLSDISFRD-AGSGYNLLLVVMDSVPDQDTPHSMPNLARFAEENVRFSNYFSAGTQQDGGLFNLFYGISTTYMDG 319 Dickeya
WP_009112289 241 MTVEYPLNDIVFRD-NGSGYNLLMIVIDDAETDAIQHGMPGLTRFAEQNIRFSDHYDSGTQPNAGLFNLFYGISTTYMDG 319 Brenneria
WP_011147092 241 LTVEYPLNDLTYQD-KGNGYNLLILVVDKLDNRDITENMPALSHFRETNIQFNQHFSTGIQNDTALFGLFYGISSGYLDG 319 Photorhabdus
WP_012989297 241 LSVEYPLNGLSYQD-NKQGYNLLLLVVDGLDNKDITNAMPSLERFTQNNIQFTQHFSTGIQNDTALFGLFYGISSGYLDG 319 Xenorhabdus bov...
WP_006704095 241 LVVEYPLNQISFGDhLGDHYNLLLIVVDNIHTNSMATEMPALAQFAQANIQFNQHYSSGNRENAGLLGLFYGISASYLDG 320 Candidatus Regi...
WP_015874410 241 PSIEYPLSKVTFDD-KGSGYNLLLIGINGINTPYFEKAMPKTAAFAEAHLQFKNHYSSGSKEETGLLGLFYGISSTYLDS 319 Candidatus Hami...
WP_004920906 240 LKIQYPLKPLSYYD-QGMGYNLLLVVVDDLGNKTQQNSMSSLKSFKEMSTEFTNHYTTGLRNDTALFGLFYGISSSYFDN 318 Providencia
WP_012367752 241 QSITYPLTPLDYSK-DESSYNLLMIVVDGLGNEDVAK-LPSLQQFADNNLSFSQHYSAGINNETALFGLFYGISPSYLDS 318 Proteus
WP_019079958 320 ILSARKPSAFITSLSAQGYQFGLFSSDGFASPLYRQALLSDFTLPAPAEQTDSETTAQWQQWLSTLNSN-APWFSYINLN 398 Yersinia entero...
WP_009639384 320 IITSRKPSALMTALAQQNYEFGLFASNGFNSTLYRQALLSDFSLPPAARQSDQQTTQQWQQWLNTRGP--RPWFSYLSFD 397 Serratia sp. M24T3
WP_016942550 320 ILGSSKPSALIDALSQQGYQFGLFSASGFSSPLYRQALLSDFSLPPPQPQSDDAITTQWVTWLDNNTGTrSPWFSFIEFN 399 Dickeya
WP_009112289 320 ILSARKPSALMTALSQQGYQFGLFSTNGFDNPLYRQALLSDFSLPAPQKQSDETITEQWRQWLNRDSNT-APWFSYIELG 398 Brenneria
WP_011147092 320 ILAGRKSSALINALTHQGYQFGLFSSVGFGTPLYRHALLSDYSLPTEVNQSNQLTVEQWQQWLN-LPNTnAPWFSFLRLS 398 Photorhabdus
WP_012989297 320 ILNSRKSSALLDALTHQRYQFGLFSSDGFQTPLYRQALLTDYSFPVPTKKDDSLTVTKWRQWLDLNHGT-TPWFSFLGIN 398 Xenorhabdus bov...
WP_006704095 321 ILAARKPSAFITALGTQGYQFGLFSSDGFKSSLYRQALLTDFSLPPPVPQRDCETTMQWQHWLTHYSPK-GKWFSYLHLN 399 Candidatus Regi...
WP_015874410 320 IFFTRKPSVLIRSLEAQGYQFGLFSSDGFKNPLYRQALFTDFSLPSPMLQSNRKTTEEWYEWFSKKLNT-RPWFSYIHFN 398 Candidatus Hami...
WP_004920906 319 ILNERYASVLIQALQKQGYQFGLFSTDGFNSPLFRQAILADYSLPAKAADSDAQTISQWDSWLKGLKNE-SPWFSFLNIK 397 Providencia
WP_012367752 319 VLSSRKNSALFDALNYRHYQLALFSTNGFKSPLFTQAVLADYSLPTSRSEDNDTTINSWRSWLLKNKQS-TPWFSFLQIN 397 Proteus
WP_019079958 399 GAVEaqDPVIGHkvalptdfIHNYQTGAKDVDQQIATILDTLKQRGQLDKTVVIITAAHGVEFNDTgNDNwgagSGFNRQ 478 Yersinia entero...
WP_009639384 398 GTSEatAIGKDGrqpsaaiiNPRYQQGASEVDGQIAEVLKNLQAKGMLNNTVVVITASKGIDLNPE-QNQ------MDEQ 470 Serratia sp. M24T3
WP_016942550 400 HATTgsNGRPLAag----eqQRRYRQDTASIDEQIDRIITTLREKNLLDKTVVVITAERSSAERLKdDDP----SPMNRE 471 Dickeya
WP_009112289 399 TASQdgESGKLSat----eqSRRTTANRQNTDQQIDRIISTLQEKDVLDKTVVIITS-RQKNLGEQ-DRA----KIFQRA 468 Brenneria
WP_011147092 399 GLDK--ADSVGN---------------AAALDGPINTVLETLKNKNALNNTVIVITAEHSETATTH-PPRwinnGKFNRA 460 Photorhabdus
WP_012989297 399 GFTHstSQFDKK-----------------ALDTEINNVLETLTNKGMLDKTIVVITAKHSELSAGH-SPKwltgDKFNRE 460 Xenorhabdus bov...
WP_006704095 400 AAAAvsNPSDEK-----------------STDQQITTIIETLKQQAQLDKTVVIITASHGVELNEStDVTwhegSQFNRE 462 Candidatus Regi...
WP_015874410 399 TASTalEPDETR---------------IKNIDQQISEMIDVLKKDPQFTKTVIIITGAYAAAENQN-----------KRI 452 Candidatus Hami...
WP_004920906 398 GK-----------------------PGSNQTDQQINQVIESLIRDGRLKNTIVIITANYNNAEQSD-TTNwfsnKRFERE 453 Providencia
WP_012367752 398 GD-------------------KHTSASQAQLNSQLETIFTTLKESNILDNTVVVVTSNYHQNNDKQdSQWlvnkDTFNLS 458 Proteus
WP_019079958 479 QLQVPLIVHWPGTPAQKVNKLTNHEDIMATLMQRLLHVKTASEDYSQGEDLFAAQRNNNWVA-TGDNGTLVITTPTQTIV 557 Yersinia entero...
WP_009639384 471 HVKVPLIIHWPGTPAQNVNKLTSHEDVMATLMQRLLHVSTSPSDYSQGEDLFAARRSNNWVTsTSNDGALVITTPTQTIK 550 Serratia sp. M24T3
WP_016942550 472 HRQVPLVVHWPETPAQTISKMTDPKDVMTTLMQRLLHVKTATEDYSQGEDLFSAERRANWLL-NGDSNSLTIITPQQVIQ 550 Dickeya
WP_009112289 469 QWQIPLIVHWPGTPAQTISKMTDNKDVMTTLMQRLLHVKNAADDYSQGEDLFSAQRSNNWLA-NGNSGDLTITTPEQIIM 547 Brenneria
WP_011147092 461 QMHVPLLIHWPGTPSQTISKLTSHQDVMTTLMQRLLHVSNTPADYSQGQDLFAAQRDNPWVI-TGDDGSLIITTSENTLF 539 Photorhabdus
WP_012989297 461 QIHVPLIIHWPGTPAQVINKLTSHQDVMTTLMQRLLHVSNSPDDYSQGEDLFTAQRDNPWLI-TGDDGSLIVTTATNTIY 539 Xenorhabdus bov...
WP_006704095 463 QFQVPLIIHWPGMPARQINKLTYHEDIMTTLMQQLLSVKTAPQDYSQGEDLFVAQRTKNWLV-TGDSDLLVVITPTQTIL 541 Candidatus Regi...
WP_015874410 453 PSKVPLIVYWPKISTQIIHKLTSHQDIMATIMQKLLHTKTAVKEYSQGENLFTPERLYPWIL-TKKNKELLVVTPRKTIA 531 Candidatus Hami...
WP_004920906 454 KMQVPLLIYWPNTPSQQIDKLTSHQDVLTTIMQRLLHVSNSPEDYSQGEDLFSPERKYPWVI-TGDDNDVVITTNSATLY 532 Providencia
WP_012367752 459 QSQVPLVIHWPNVTPQKLDKLTSHQDIMTTLMQHVLGVISPADNYSQGEDLFANTRNHPWIF-TGDNETLVVFLQDNTLM 537 Proteus
WP_019079958 558 LDNNGEYRTYDMQGNEIKDEKPQLPLLLQVLTDIKRFIAN 597 Yersinia enterocolitica
WP_009639384 551 LDHDGNYHAYDSHGNELKDQKPELGLLLQVLTDQKRFVAN 590 Serratia sp. M24T3
WP_016942550 551 LGRNGSYRAYDANGRLLPDEKPQLGLLLQVLTTERRFIAN 590 Dickeya
WP_009112289 548 LESNGSYRAYDREGRKLNDEKPQLALLLQVLTNERRFIAN 587 Brenneria
WP_011147092 540 LDKNGNYHLYDLEGNEIKDAKPNLAQLLQILTEVKHFIAN 579 Photorhabdus
WP_012989297 540 LSKNGEYYLYDLDGNEIQGAKPNLAQLLQILTEVKRFLAN 579 Xenorhabdus bovienii
WP_006704095 542 YQE-GKHRIYDQQGREIKENKPSLSLLLQVLTETKRFIAN 580 Candidatus Regiella insecticola
WP_015874410 532 LDDNGSYHTYDQNGILIQNDTSELSLLLQVLTETKRFIAD 571 Candidatus Hamiltonella defensa
WP_004920906 533 MDHNGQFSIYDLQGREVKDQKPDLAQLLKIFTELKRFNEN 572 Providencia
WP_012367752 538 IDKHGRYALFDKSGKEIQSAKPDLRLLLQVLAEQKRFIER 577 Proteus
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