1A6J,1A3A


Conserved Protein Domain Family
PTS_IIA_fru
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cd00211: PTS_IIA_fru 
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PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.
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Statistics
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PSSM-Id: 238129
Aligned: 109 rows
Threshold Bit Score: 86.8463
Created: 16-Aug-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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phosphorylationactive site
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:phosphorylation site [posttranslational modification site]
Evidence:
  • Comment:residue receiving phosphoryl group from donor HPr
  • Citation:PMID 9551558
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                         #           
1A6J_B     14 LNreCTRSRvh-cQSKKRALEIISELAAKqlslppqVVFEAILTREKmgSTGIG--------NGIAIPHGKleedtlRAV 84  Escherichia coli
NP_241058   6 FNesNILLNve-aITSEEVLTIMGKKLHHlgl-vkeSFVNAVISREKsfPTGLPts-----sIAVAIPHTDphh-vkQKT 77  Bacillus halodurans
NP_370769   6 VHkeNIMLNls-aTDKESVLSQMSDVLFQngf-vksTFKDAVIDREKefATGLPth-----lCSVAIPHTDveh-inHRT 77  Staphylococcus aur...
NP_464031   6 YFkeEMVRFsn-eQNKEKLLAEMAEQLCEvga-vkpSYKDAVIKREKvfPTGLLta-----hAGVAIPHTDseh-viRPV 77  Listeria monocytog...
AAG09977    6 IYndLISLNhr-yRDQTNLLEVLSQYLLQkgy-vktEFSKAILQREKdyPTGLQle-----nMAVAIPHTYsey-vlKPF 77  Streptococcus agal...
NP_358156  21 FFdkNLVFCle-aDNQEQLFDQVATLLEErei-vtpTYREALITREKsfPTGLDmeflgkdlPNVAIPHTDivh-nlAEK 97  Streptococcus pneu...
NP_349560   8 LFkeDLIFIed-aKDSNEIFKKIGQRLIQkgl-vkdNFIDGIIEREKkyPTGMDlsviegqeYNVAIPHTErey-clSKR 84  Clostridium acetob...
NP_462171   1 MSqlFVRTGitfdSSQQALAHIGKEMLAKgvv--hdSYPQALVEREAsfPTGIAle-----rHAVAIPHCEavh-akSPA 72  Salmonella typhimu...
NP_466189   7 LKkgMVWVQsd-iEKQEDLFQMVAESGKSegy-vtdDFLTRLTDREQtfPTGLKld-----gYGVALPHTDpec-vtEQF 78  Listeria monocytog...
NP_465622   6 LFqkELTLInsryESQAELFEYTSKILEKeqy-vepTFREAVTSREVvfPTGLEmn-----gIKIAIPHTDtiy-vkRPF 78  Listeria monocytog...

Feature 1                                                                              
1A6J_B     85 GVFVQLETPIAFDaid----nqPVDLLFALLVpadqtkTHLHTLSLVAKRLADKTICRRLRAaqSDEELYQII 153 Escherichia coli
NP_241058  78 ICFAALKDQVDFGvmgetdvntPVKLVFMLAMte--aeSQLSLLKHLIDLFQEEDTLMMLVNetTETKIYDII 148 Bacillus halodurans
NP_370769  78 IGVAVLEKEVPFIemgtldqqtEVKIVFMLAMdk--vdDQLKLLQQLMQIFQSEEKLEQILRtkDETILATLI 148 Staphylococcus aureus sub...
NP_464031  78 VAVRILKKPVSFIemasdneaiDVRIVFMMALrs--adEQLDMLQTLIQLIQDEEVMTTLLKaqETGDVLSAI 148 Listeria monocytogenes EGD-e
AAG09977   78 IYINKLKEPISFIqmgtedeivMARYVIVLGIsn--pkDQAGLLAELMTLFSNPKIVQQLEMaqTKEALKNIF 148 Streptococcus agalactiae
NP_358156  98 VVVVRLEKPVTFHnmiapdkevEVSLLFFIINns--ssSQTNILAQLMDFFTGNGHLEDLSKisEPEKLYAYI 168 Streptococcus pneumoniae R6
NP_349560  85 IVFVKLKKEVEFKnmiapedtlKVRYLFMIINne--ndAQTNILANIMDFITNKENMDKLNKtdNEEEIFEFI 155 Clostridium acetobutylicum
NP_462171  73 IYLIRPDKPVMFQqadd-deeiAVSLIIALIVen--paAQLKLLRRLFSELQNPSTLDALLSapDAELAIRFQ 142 Salmonella typhimurium LT2
NP_466189  79 IAVITVKDGIPFKlmedagqtvEANLIFVLGLne--phSQLAVLQQLMGTIQDKDNVAALLRakDEDEVKQIL 149 Listeria monocytogenes EGD-e
NP_465622  79 VLVNKLSTPIPFVqmgtvdkwiDVEVIFMLGIkn--pqDQVPLLSSIMEKFMEADFVEQIKEinDSNTLCDFL 149 Listeria monocytogenes EGD-e

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