5YFG


Conserved Protein Domain Family
Mog1

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pfam04603: Mog1 
Ran-interacting Mog1 protein
Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran. The human homolog of Mog1 is thought to be alternatively spliced.
Statistics
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PSSM-Id: 461364
Aligned: 122 rows
Threshold Bit Score: 110.705
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YFG_A         7 CPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFc-hPVT-------------DQSLIVELLELQAHVRGEAAARYHFEDVG 72  human
CCG82215     223 RDLFGSTIETAVPKSWLDASLLRQVPDTQEVFldpDNA-------------DRSFIVELVERLD-VSDPDAGTEHYKVLS 288
XP_003645892   5 QALYGGAITTVVPEGFLDASILREVPDTQEVYv-nSREepekfd--dglgtNESIIFDLLQRVDETDDVKALHVHLEEIS 81 
XP_002551837   5 QALYGGAISTVIPKGFLDASILREVPDTQEVFv-nSREekeiavfkdglglDESVIVDLLQRVEEDDSCRALDVHLQEIA 83 
Q6CV72         7 QELYGGAISTVIPKTFLDASMLRQVPDTQEVFv-nSRRenepse--dglgfDESVIVDLMQRVEENNDRKALDIHLAEIS 83  Kluyveromyces l...
Q752Y7        27 QPLYGGKISTVIPHGFLDASALREVPDTQEVFv-nNRDapgad----glgtNESVIVDLLERADD-DDEAALRTHLEDVA 100 Eremothecium go...
XP_004179344   5 VQLYGGAITTVMPEGFVDVSMIREVPDTQEVYv-nNREsketft--dglgyNESIIVDLLEQVTSMDLKLALGEHLEDIF 81 
EGG18397      11 KGLYGGAMEIEIPTRFIDVSQFRQVPDHQEVFv-dETS-------------DQSVIIELLERQSHIEDNKSASFHFDTIS 76 
EFA74839       7 RQLYGGAIEISIPSRFIDITAFRVIPDHQECFv-dDRT-------------DQSIIIELLERQDHVADHESAAFHFNVVA 72 
EGC38065       8 RPLYGGAIEISIPERFRDITQFRQVPDHQEVFv-dEKS-------------DQSFIVELNEKQS-VVDDQAILFHYENLT 72 
5YFG_A        73 GVQGARa-----------vHVESVQPLSleNLaLRGRCQEAWVLSGKQQIAKEnq--qvAKDVTLHQALLRLPQYQTDLL 139 human
CCG82215     289 EDNDAAahhitkt---------------evilpaQDGQDCKILVSGSQKIAKFnt--ptQKEISVVMGIVRLAKVSTDVL 351
XP_003645892  82 SINETNawtilyheqkgavQR----------------------CIAVETVLKWgkkelsE-TLILCLSLIRLEDVETDII 138
XP_002551837  84 GLNGSHewnlve-ceqsapEV-------------GQVPH--LTCIAVEAAYKWgksdmrE-TLVLCVALLRFDDVQTDVV 146
Q6CV72        84 ELNGSQkwtv--------------------idhqEQTELKSQTCIVVETAYKWgkqsmkE-TVVMCVALLRLDQFDTDVI 142 Kluyveromyces l...
Q752Y7       101 LRNGSGawrllcceragprT----------------------TCVALAPVLKWgqvaraE-TLVLCFGLLRLPHVATDVA 157 Eremothecium go...
XP_004179344  82 QLNGSTkykveqlkqidnhNI---------------------TCIVWEETHKSgkqartE-IVMSCIGLIRLAEFTTDVL 139
EGG18397      77 DESDIPad---------grIVFNHRPIDsaEMpHFTNETPKFLLFGQQKVAKFnet-gsENIVNVYMAIVRLSKSQTDVL 146
EFA74839      73 DEADVAad---------krTILNHRALTktDMpHFEDEVPKFILLGKQMMSKFne--taENTLNVYMAIVRLNRSKTDLL 141
EGC38065      73 EELELPke---------ksVVLNQRKLTndEL-PNFPNNPKYILLAQQKVAKFke--saENTVNLYMLLVRLEKQNTDIL 140
5YFG_A       140 LTFNQP 145 human
CCG82215     352 LMYNAP 357
XP_003645892 139 ISVNVP 144
XP_002551837 147 LSVNIP 152
Q6CV72       143 ISVHVP 148 Kluyveromyces lactis
Q752Y7       158 ISVNCP 163 Eremothecium gossypii
XP_004179344 140 VTMNVP 145
EGG18397     147 ITLYHP 152
EFA74839     142 ITLNAP 147
EGC38065     141 IILNDT 146
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