Conserved Protein Domain Family
CLEC16A_C

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pfam19439: CLEC16A_C 
CLEC16A C-terminal
This is the C-terminal domain of C-type lectin domain family 16, member A (CLEC16A, the Drosophila orthologue Ema and GOP-1 in C. elegans), an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction. This domain is also present in GFS9/TT9 (TRANSPARENT TESTA 9) a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles and for membrane trafficking machinery and accumulation of flavonoids in the seed coat.
Statistics
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PSSM-Id: 466083
Aligned: 8 rows
Threshold Bit Score: 1237.07
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_018091787  244 RNRGNLSNLVSQHLDHLNYLNDILIINCEFLNDVLTDHLLNRLLLPLYVYSLVTQDEP-----GDRp------------- 305 
3_pfamImport    1 KNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLVSPETF-----EER-------------- 61  
XP_015260399  253 KNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLVSPETS-----EER-------------- 313 
RXN12873     1293 KNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLVTQEQS-----EER-------------- 1353
KPP74969      241 KNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLVGNEQDkflslGPRhapllhlstslpaq 320 
XP_027817231  245 RNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKG-----GERp------------- 306  sheep
XP_007498709  243 RNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLVNQDKG-----GERp------------- 304  gray short-ta...
XP_031462573  243 RNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLVNQDKG-----GERp------------- 304  Ring-necked p...
XP_018091787  306 ----RISRQVSLYLLSQVFLTIHYAPLVDSLADVILNGDLSVFSSKAELDAKRIS--A-ESSVRCFIKPQETLEKSLEIN 378 
3_pfamImport   62 ----NINPQVSLYLLSQVFLIIHYQPLVNALADVILNGDLSVCTSQTDEHSTYKN--T-VPDILCACRVDTTVSTALTVH 134 
XP_015260399  314 ----KINPQVSLYLLSQVFLIIHYQPLVNALADVILNGDLSVFIGQTDVHSTHKNthAsAGALRRFIKPPESLERSLEMS 389 
RXN12873     1354 ----KINPQVSLYLLSQVFLIIHYQPLVHSLADVILNGDLSVFTVQTEQSAHKSS--S-NAGVRRFAKPPESLERSLEMS 1426
KPP74969      321 pedrKISPQVSLYLLSQVFLIIHYQPLVNSLAEVILDGDLSVFSVSSEQDAQKST--S-SASVRRFTKPAESLERSLEIS 397 
XP_027817231  307 ----KISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYAKPEQDVQRSC--A-KPSIRCFIKPTETLERSLEMN 379  sheep
XP_007498709  305 ----KISLPVSLYLLSQVFLIIHYAPLVNSLAEVILNGDLSVLCCGTEQDVQRCS--I-KSSIRCFIKPTESLERSLEIN 377  gray short-ta...
XP_031462573  305 ----KISLQVSLYLLSQVFLIIHYAPLVNSLAEVILNGDLSVFSSKAEQDvqk--nsA-KSSIRCFIKPTETLERSLEIN 377  Ring-necked p...
XP_018091787  379 RQRGKKKLQKRPNYKNVGEEEEEgdk-gsEEISEdpdkakg-------------------tessskgTKTSGETE-EIEM 437 
3_pfamImport  135 FHGDTPSILRSSPLTPAYARLNI------SWGQDa-------------------------------gISLSLYMMrKIEM 177 
XP_015260399  390 RHRGRKKTQKRPNYKNLGEEDDEraggggGGGGEleeswdddssrgerekgkgteglggggsgsskgGRASGEMAeEIEM 469 
RXN12873     1427 RHRGRKRTQKRPNYKNVGEEEEEerg-seEGPEEekekakg-------------------teasskaSRTSGDKE-EIEM 1485
KPP74969      398 RQRGRKRTQKRPNYKNVGEEDEGnke-seEGADSpdrakat--------------------easskgAKTSGDME-EIEM 455 
XP_027817231  380 KHKGKRRVQKRPNYKNVGEEEDEekg-paEDAQEdaekakg-------------------teggskgIKTSGENE-EIEM 438  sheep
XP_007498709  378 KQKGKKRLQKRPNYKNVGEEEEEek--gpEETQEdadkakg-------------------iegtskgIKSGGDSE-EIEM 435  gray short-ta...
XP_031462573  378 KQKGKKRVQKRPNYKNVGEEDEEer--qsEDTQDdldktksteas--------------------skgirtsseneEIEM 435  Ring-necked p...
XP_018091787  438 VIMERSKSAEks---aVTEENTTDEEKSAAa-AgAE-ACQN-RPFLDMVYSNLECTEDDYYTLFVLCLLYAMTHNTGINP 511 
3_pfamImport  178 VVMEKCKATE------LTEQNITDEEKSAAa-T-RT-HTQRyRPFLDMVYSALDCTNDDYHALFVLCLLYAVSHSKGVNK 248 
XP_015260399  470 VVMDKCTASEl------aEQNITDEEKTAAa-T-RT-NTQRsRPFLDMVYGALDCTSDDYHALFVLCLLYAISHSKGVNQ 540 
RXN12873     1486 VVMEKCRISDvs---tLTEQNITDEEKSAAa-A-RS-EGQKcRPFLDMLYNAMDCDTEDYQALFVLCLLYAMSHSK---- 1555
KPP74969      456 VVMEKCKISEls---aLTEQNITDEEKTAAaaAgA--DGQRsRPFLDMVYNALDCTVDDYYALFVLCLLYAMSHSRGINP 530 
XP_027817231  439 VLMERSKLPElaagasVQEQNTTDEEKSAA--TgLD-SVQWsRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDP 515  sheep
XP_007498709  436 VIMERSKLTElai-svVTEQNTTDEEKSAAa-SgSE-TTQWnRPFLDMVYNALDNPEDDYHALFVLCLLYAMSHNKGIDP 512  gray short-ta...
XP_031462573  436 VIMERCKLSElsi-saVTEQNTTDEEKSAAa-S-GseITNWnRPFLDMVYNALDCAEDDYYALFVLCLLYAMSHNKGIDP 512  Ring-necked p...
XP_018091787  512 SKLERIQLFVQPTqENRTYNHVLAERLIRIMSQAAQT--DSKVRLSTLELTCVLLKHLVLHDSGCIIKDVHLACLEGARE 589 
3_pfamImport  249 DLLERLQLPVPDQ-ERNSYSLVLVERLIRVMSQAAQPgnTDTCSLLSLYPFCTYNEYIVITMSDIFQEATGLCSLQGARE 327 
XP_015260399  541 DLLERLQLPVPNQ-ERASYSVVLVERLIRIMNQAALP--DGKVRLATLELSCLLLKQSVLSGSHCLIKDVHLACLEGARE 617 
RXN12873     1556 ---------------------------------------DGKVRLATLELSCLLLKQAVLSGSQCIIKDIHLACLEGE-- 1594
KPP74969      531 QLLERIQLPVQQQ-ERSNYSQVLAERLICVMNQAAQP--DGKVRLATLELSCLLLKHSVMSASSCIIKDVHLACLEVG-- 605 
XP_027817231  516 EKLERIQLPVPTAaEKTTYNHLLAERLIRIMNNAAQP--DGKIRLATLELSCLLLKQQVVTSTGCIIKDVHLACLEGARE 593  sheep
XP_007498709  513 EKLDRIQLPVQTEvEKISYNHLLAERLIRIMNYAAQP--DGKIRLATLELSCLLLKQQVMTNSGSIIKDVHLACLEGARE 590  gray short-ta...
XP_031462573  513 VKLERIQLPAQHAeERNSYNHVLAEGLIRIMNYAAQP--DGKIRLATLELGCLLLKQLVFSKNGSIIKDVHLACLEGARE 590  Ring-necked p...
XP_018091787  590 ESIHLLRHFYKg-EEIFLDMFEDEYRSMTSKPLNVEYLMMDESILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFML 668 
3_pfamImport  328 ESLHLLRRFYKv-TGVFFFFFQVSYRCFTSKPLNVEYLMMDASVLLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFML 406 
XP_015260399  618 ESLLLLRTFYKg-EEIFLDMFEDEYRSMTNKPLNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRKAIRVFFML 696 
RXN12873     1595 --------------EIFLDMFEDEYRSMMNKPLNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVERTRRAIRVFFML 1660
KPP74969      606 ---------LPwgEEIFLDMFEDEYRTMTNKPLNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVERTRRAIRVFFML 676 
XP_027817231  594 ESVHLVRHFYKg-EEIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFML 672  sheep
XP_007498709  591 ESVHLVRHFYKg-EEIFLDMFEDEYRSMTIKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVERTRRAIRVFFMY 669  gray short-ta...
XP_031462573  591 EGVHLLRRFYKgeeifldmf-edeyrsmtIKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVERTRRAIRVFFML 669  Ring-necked p...
XP_018091787  669 RSLSLQLRKELETQLPLTREEDLIKMDDVLDLNN-SDLIACSVLTKDGGQAQRFLAVDIYQMSLVEPDSKRLGWGVVKFA 747 
3_pfamImport  407 RSLSLQLQGEPETQLPLTRTEDLIKTDDVLDLNNmSKLFDSVVFFKSEGNQKLELAVDVYQMSLVEPETKRLGWGVVKFA 486 
XP_015260399  697 RSLSLQLQGEPETQLPLTRPEDLIKTDDVLDLNN-SDLIACMVVSKDGSQAQRFLAVDVYQMSLVEPETKRLGWGVVKFA 775 
RXN12873     1661 RSLSLQLQGEPETQLPLTRPEDLIKTDDVLDLNN-SDLIACMVVSKDGVQAQRFLAVDVYQMSLVEPDSKRLGWGVVKFA 1739
KPP74969      677 RSLSLHLQGEPETQLPLTRPEDLIKTDDVLDLNN-SDLIACMVVTKDGSQAQRFLAVDVYQMSLVEPDSKRLGWGVVKFA 755 
XP_027817231  673 RALSLQLRGEPETQLPLTREEDLIKTDDVLDLNN-SDLIACTVVTKDGGMLQRFLAVDIYQMSLVEPDVSRLGWGVVKFA 751  sheep
XP_007498709  670 RSLSLQLRDEPETQLPLTREEDLIKTDDVLDLNN-SDLIACTVITKDGGLVQRFLAVDIYQMSLVEPDVARLGWGVVKFA 748  gray short-ta...
XP_031462573  670 RSLSLHLQGEPETQLPLTREEDLIKTDDVLDLNN-SDLIACTVITKDGGQVQRFLAVDIYQMSLVEPDVARLGWGVVKFA 748  Ring-necked p...
XP_018091787  748 GLLQDMQVTGVEDDSRALNITIHKPASTPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRISALLDLPVQ 827 
3_pfamImport  487 GLLQDMQVSGVEDDSRALNIIIHKPSSNPHAKPLPILQANFIFADHIRCIIAKQRLAKGRIQARHMKMQRITALLDLPVQ 566 
XP_015260399  776 GLLQDMQVSGVEDDSRALNIVIHKPSSNPHAKPLPILQANFIFADHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPVQ 855 
RXN12873     1740 GLLQDMQVSGVEDDSRALNIIIHKPTSNPHAKPVPILQANFIFADHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPVQ 1819
KPP74969      756 GLLQDMQVSGVEDDSRALNITIHKPTSNPHAKPFPILQAVFVFADHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQ 835 
XP_027817231  752 GLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQ 831  sheep
XP_007498709  749 GLLQDMQVTGVEEDSRALNIIIHKPASSPHSKPFPILQATFVFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQ 828  gray short-ta...
XP_031462573  749 GLLQDMQVTGVEDDSRALNIIIHKPASSPHSKPFPILQATFVFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPVQ 828  Ring-necked p...
XP_018091787  828 PS-TEVVGFGHSSSAaAQHLPFRFYEQSRRTLSDLAMQRSGFGSVDKVPGF------AVAQCINQHSSSPASSPSp--PS 898 
3_pfamImport  567 PSaTEVLGFSQTANAsPSALPFRFYEQSRRAPNDPTASRSVFASVDRVPGF------AVAHCVSQHSPSPLSSPSp--PS 638 
XP_015260399  856 PSaTEVLGFGQTASAsPSGLPFRFYEQSRRAPNDPTANRSVFASVDKVPGF------AVAHCVPQHSPSPLSSPSp--PS 927 
RXN12873     1820 PS-TEVLGFSQPSVAsS--LPFRFYDQSRRGP--------AFASVDKVPG--------KRDC--GSQNSWIDAKCfekPD 1878
KPP74969      836 PT-SDVLGFSQSMAAsSQQLPFRFYDQTRRGPLETGTPRSVFASVDKVPGlagkdggGCLVC-PRRTGAADTGFRp--PS 911 
XP_027817231  832 PA-TEVLGFGLGSSS-AQHLPFRFYDQCRRGSSDPTVQRSVFASVDRVPGF------AVAQCINQHSSSSLSSPS---PS 900  sheep
XP_007498709  829 PS-TEVMGFTLTTSAsNQHLPFRFYEQSRRGSSDPTVQRSVFASVDKVPGF------AVAQCINQHGSSPLSSPSp--PS 899  gray short-ta...
XP_031462573  829 PS-NEVMGFGHSSAAaSQHLPFRFYDHARRGssdptVQRSVFASVDKVPGF------AVAQCINQHHPSPLSSPS---PS 898  Ring-necked p...
XP_018091787  899 Sg----------sSSGSTGVCDSGTTSLTSTPStl-------------------------------------------hs 925 
3_pfamImport  639 S------------GSGSTGRCDSVTASTISAQS----------------------------------------------- 659 
XP_015260399  928 S------------GSGSTGRCDSVTASSASFQS----------------------------------------------- 948 
RXN12873     1879 LfivcrwitsksyGFAVAHIAQHNPTSASSTSP----------------------------------------------- 1911
KPP74969      912 Srd--------psSPGRSLYSAHLGTAEGGGGGll--------------------------------------------t 939 
XP_027817231  901 Asgs-------psGSGSASHCGSGGASSSSTPSaa-------------------------------------------qs 930  sheep
XP_007498709  900 Sgs--------ssGSGSTGRCDSVAPSSTSTPS----------------------------------------------- 924  gray short-ta...
XP_031462573  899 S------------GSGSTGRCDSVAASSASTPSvaqspsddssapeqprttvsgqmtltdetlsavskssksavknsdle 966  Ring-necked p...
XP_018091787  926 PS-------DDASVCDQPQ-----LTPsnqEE---------SADEAQAavskIRKSSLnkSDTE---KTNLAPSLTPAPQ 981 
3_pfamImport  660 PA-------AIGTTPPQERidrqaFPN---EG---------AFLDHTP----PSSSSA--AEGEg--AAALAPSLTPASQ 712 
XP_015260399  949 PS-------DDGACLERTP-------S-----------------SSSGcdgeGGEAPStpSNPV----PALAPSLTPASQ 993 
RXN12873     1912 PS----------SAPSGPS-------D------------------SVTassaSTHTITq-SQTG----LALAPSLTPAPQ 1951
KPP74969      940 PSaqqrhrrHRPNRSNRPQt---tSPAl-rALgvgrpclrrGLLTRDDatfmDQTTPSssSEVEpgxPPTLAPSLTPAPQ 1015
XP_027817231  931 PA-------DDPMITEQPQp---nLPD---QL---------VIVNETEaearPGKSLArsTDME---PVTLSPSLTPAQQ 985  sheep
XP_007498709  925 --------------------------------------------------------------------AAQSPS------ 930  gray short-ta...
XP_031462573  967 TA-------------------------------------------------------------------NLSPSLIPAQQ 979  Ring-necked p...
XP_018091787  982 PTISLISDENTDALSVESLTLVPPVDPQSIHSIS 1015
3_pfamImport  713 PTISLLPESSSDSLSVESLTLLPPADSPHLYPCA 746 
XP_015260399  994 PTISLLTDSSADTLSVESLTLLPPADSPHLHPCA 1027
RXN12873     1952 PTISLLSDNDAETLSVDSLTLLPPADPPRLRSFS 1985
KPP74969     1016 PAISLFSDDGTDALSVESLTLLPPADPPRLRSLT 1049
XP_027817231  986 PTISLLCEDAADTLSVESLTLVPPVDHHSLHALT 1019 sheep
XP_007498709  931 ---------VRSGRKGRRRVFSLSEADSHGGHWV 955  gray short-tailed opossum
XP_031462573  980 PTISLISDDNTDALSVESLTLVPPVDSHSIRTFS 1013 Ring-necked pheasant
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