Conserved Protein Domain Family
TMEM237

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pfam15383: TMEM237 
Transmembrane protein 237
This protein family is found in eukaryotes. The function of this protein is to aid the production of new cilia in ciliogenesis. Mutations in the protein cause a disease, named Joubert syndrome type 14 (JBTS14) and also affect cell signalling using the Wnt pathway. Proteins in this family are typically between 203 and 512 amino acids in length. There are two completely conserved G residues that may be functionally important.
Statistics
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PSSM-Id: 464690
Aligned: 16 rows
Threshold Bit Score: 235.736
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002111935 177 DFDHDLNLSPEDV--------ITSK--DYNIEITePPNLVPSLPSQPLNV-----VYVERTdgggfRRVNKSNlnd-mkK 240
F1Q930       116 QSHNELGVEEDDI--------ITDV--HAPISQR-SLFSAPLSHSHPIGK-----VFVEKN-----RRFQATD------L 168 zebrafish
4_pfamImport   1 HHSNQPQDQDEGM--------MGDG--QAP-----PLFSAP--HSQPGGR-----GSLGRT-----REHFQSErvd-qlR 52 
ESN99035       9 glsNDLEGMEEDVqstnqifsVNDF--AKIISQQ-----SNTVPSQADDK-----IYIEGS-----DRFKAKNrlkvdqK 71 
OWR54055     250 ARPSDLTAMLESLean---vpFNDQyiDNPFSSPsPLTSPNDERRDPFGSrrpekIYLQGG-----GTFRAVSrdr-ilE 320
XP_014343574 131 lYPSELGVEEDDI--------ITDG--QVKGNEQ-PVFIVPSGTSQPVGK-----VFVERN-----RRFQAADrse-liK 188
F1NVK6       125 HSSNELEVEEDDI--------IEDE--HRRSPDQqPVFAAPTGISQPVSK-----VFVEKN-----RRFQAADrae-liK 183 chicken
XP_016280170 286 HYTNELGVEEEDI--------IADE--QNHPEQQpSVFTAPMGVSQPVGK-----VFVEKS-----RRFQAADrse-liK 344
EDL98964      27 QYASELGVEDEDV--------ITDE--QSTLEHH-SRFTAPTGVSQPVGK-----IFVEKS-----RRFQAADrse-liK 84 
XP_015214815 134 QYTNELGVEEDDI--------ITDV--QHPIPQH-SLFSAPLGNSQPVGK-----VFVERN-----RRFQAAErse-lnK 191
XP_002111935 241 DKD-IDaLKSKMSNI----TNSAQLGSSVFNIFMKIAFFCEGLLAGFAL--WQTISISTIE-NQVNGTITVLACYNRLSQ 312
F1Q930       169 SHDhLE-EYMEVRPM----WNTRDVAMRVHSGFRIIGLFSHGFLAGYAV--WNIIVVYVLAgEQMTTLPNLLQQYHSLAY 241 zebrafish
4_pfamImport  53 HSDlIN-DYVEPRQT----WTTREVAMKVHSSFRVLGLFSHGFLAGFAV--WNTVVVYQLAgEQLSSLRNLLQQYQKLAG 125
ESN99035      72 RAEeLErSQNENMDIyptiLTSQ--AIQIHKIFKTFSLFVSGLFAGIAL--WQIITSYIMYnNGVDN---FLRNHSTLSA 144
OWR54055     321 SQQsRE----EEKYLhlgdLTPLDVAITVQKAWRNFSPACHGVLGGISLmhLLLISYS----DSLDAG--HLSFHAVVTM 390
XP_014343574 189 TTEqID-VFMEVKPL----WTTKDVALKVHRGFRMIGLFAHGFLAGYAV--WNIIVIYVLAgNQLSALSNLLQQYRTLAY 261
F1NVK6       184 TTEnIN-VLLDVKSS----WTTRDVALSVHRSFRVIGLFTHGFLAGYAV--WNIVVIYILAgNQLTTVSNLLQQYKMLAY 256 chicken
XP_016280170 345 TTEnVD-MLMDIKPS----WTTRDVALSVHRGFRMIGLFSHGFLAGYAV--WNIIVIYVLAgKQLSDLSNFLQQYKSLAY 417
EDL98964      85 TTEnVD-VSMDMKPS----WTTRDVALSVHRAFRMIGLFSHGFLAGCAV--WNIVVICVLAgDQFSNVSNLLQQYKPLAY 157
XP_015214815 192 PAEqVD-DYMEVKPL----WTTKDVAMRVHRGFRVIGLFSHGFLAGYAV--WNIIVVYVLAgNDLAALPNLLQQYKTLAY 264
XP_002111935 313 AAQSVYYFLLAIATVSVMDR-FDLESHEYVslITRFIRHPVLALCILIHILSLILSTSIAEIDYRIGLY---NVNQSFyW 388
F1Q930       242 PAQSLLYLLLAISTVSAFDR-VNLAKASMA--LRGFLTLDPAALASFLYFAALILSLSQQMTSDRIHLYp--TANETL-W 315 zebrafish
4_pfamImport 126 PAQSLSYLLLAISSVSAFDRrLNLARASMA--LRGFLRLESAALA---FFCGLVLLWSAEQTGPDLHRGslfSANQTL-W 199
ESN99035     145 PLQCFYYMLFAVCIVYALDR-YDITHPSPHf-WNKVATFQSGAFCIIIYIIGLIFSLAISNIEYRMTFH---QSNSSI-- 217
OWR54055     391 PYVASYYFFCVLCLLSVLDR-LDITSIDTT---RGLQPWFQPIVLVILYTSCLLVCTAARMYD-ELMVYqytPLVANI-- 463
XP_014343574 262 PGQCLLYLLLAVSTVSAFDR-LNFAKTSMA--LRGFLTLDPAALASFLYFAALILSLSQQMTSDRINLYtppSENNSI-W 337
F1NVK6       257 PAQSLFYLLLSISTVSAFDR-IDLAKASVA--LRGFLTLDPAALASFLYFTALILSLSQQMTCDRINLYtppSENGSI-W 332 chicken
XP_016280170 418 PAQSLLYLLLAISTISAFDR-IDFAKTSVA--IRGFLALDPTALASFLYFAALILSLSQQMTSDRIHLYtpaTVNGSL-W 493
EDL98964     158 PFQSLLYLLLALSTVSAFDR-IDFAKTSVA--IRNFLALEPTALASFLYFTALTLSLSQQMTSDRIYLYe-pSVNGSL-W 232
XP_015214815 265 PSQSLLYLLLALSTVSAFDR-VNLVKASVA--LRGFLTLDPAAVASFLYFVALILSLSQQMTSDRINLYs--PNNETL-W 338
XP_002111935 389 PTVTDQNVrrlttqsqtlFSSWRIINLLRGILAIAGWMLVSFNPITA 435
F1Q930       316 PPGLEHQI----------LQPWIVVNLVVALLVGLAWVFVATRPDMD 352 zebrafish
4_pfamImport 200 PPSSEQQV----------LRPWMVVNLVVALLVGVAWVVVSTRPNTD 236
ESN99035     218 IDPNDSRTtn-------mLYIWQILNLIRGLMAIIGWGIISLKPMTD 257
OWR54055     464 ------TGnvttptiptfYHTWTHFSIWRSVLSILGLVYFVISNPQD 504
XP_014343574 338 TAGTESQI----------LQPWIVVNLVVALLVGLAWIFLSYDPGLD 374
F1NVK6       333 TAGMEEEI----------LQPWIVVNLVVSILVGASWIFLSYRPELD 369 chicken
XP_016280170 494 VAGTEEQI----------LHPWIVVNLVVALLVGLSWLFLSYRPEKD 530
EDL98964     233 PAEVEEPV----------LMPWVIVNLVVALLVGLAWLFLSYRPGMD 269
XP_015214815 339 PAGTEHQI----------LQPWVVVNLVVALLVGLAWVFLSTRPLTD 375
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