1W5O


Conserved Protein Domain Family
HemB

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COG0113: HemB 
Delta-aminolevulinic acid dehydratase, porphobilinogen synthase [Coenzyme transport and metabolism]
Delta-aminolevulinic acid dehydratase, porphobilinogen synthase is part of the Pathway/BioSystem: Heme biosynthesis
Statistics
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PSSM-Id: 439883
Aligned: 759 rows
Threshold Bit Score: 444.822
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1W5O_A        12 YTRLRRNRRdDFSRRLVRENVLTVDDLILPVFVLDg--VNQRESIPSMPGVERLSIDQLLIEAEEWVALGIPALALFPV- 88 
WP_015774560   4 FHRGRRLRSkKVLRDMVRESRLGREDLIQPYFVVEs-dPDFRKPIASMPGQFQLGLNQLMGDVGTAVDAGLSSLILFGI- 81 
WP_015752381   6 FFRGRRLRQtATMRALVRETVLRPEDLIQPYFVAEg-dRHASRPIGSMPGQHQLGLEALTARVSQAVDNGLHAVMLFGI- 83 
WP_013074709   3 FDRHRRLRWtPGMRDLWRENRLSIEALMYPLFAVHg--SGVREPISSMPGVEHLSVDELRREAVELAELGVRSILLFGI- 79 
WP_013515123   6 FHRGRRLRSsLTLREMVRENEVRPQDLIMPYFVAEtddESFIKEISSMPGQYQLSLKQLEKKVGEAVTNGLRSCILFGI- 84 
YP_010077      4 FFRGRRLRRtAALRELVRENVVCAADLIMPYFVVEtdePAFRKEIGAMPGQFQLSLQELEKQVEAAVAKGLRAVILFGI- 82 
WP_041695809   6 FRRHRRLRRtPYLRDLVREHRVHADDLVYPMFVQEg--LNGTSPIHSMPGVFRYGLDALRREIASLSELGLKSVILFGI- 82 
WP_015255411   5 LIRHRRLRRtAALRELVRETVLTAADFMYPIFVTHg--RNVREEVKSMPGVFNFSIDRLGEEIERVREAGVKSIMLFGI- 81 
WP_087458665   6 FDRHRRLRSsAGIRAMVRENHVTVNDLIHPLFVVEg--NNVKHEIPSMPNVFHFSLDNFRREVNEVSELGIPSIILFGV- 82 
WP_123041306   5 NTRHRRLRGsAALRSMVRETSLSADDFIAPIFIARg--TGVKQEISSMPGVYNWSLDRMGEELSQLARLGIRAVLVFGVp 82 
1W5O_A        89 -TpvEKKSLDAAEAYNPEGIAQRATRALRERfPELGIITDVCLCPFTTHGQCGILDDd----GYVLNDVSIDVLVRQALS 163
WP_015774560  82 -P--VEKDPAGTQAYAENGIVQQAIRRIKDRwPELIVVADTCLCEYTSHGHCGLVSPe----GVVRNDPTLALLARTAVA 154
WP_015752381  84 -P--ESKDPQGSQAYAPEGIVQEAVRRLKAAvPELTVITDVCLCEFTSHGHCGLVDG-----QQVLNDPTLELLAATAVS 155
WP_013074709  80 -P--AHKDERSSEAYDEGGIVQQAIRAVKEEvPEMVVATDVCLCQYNPAGHCGIVRN-----GVILNDETLPLLARTALS 151
WP_013515123  85 -P--AQKDETGSQAYADSGIVQQAIRLLKDRwPDLMVVADTCLCEYTSHGHCGLVKN-----NEVLNDPTLNLLARTAVA 156
YP_010077     83 -P--KVKDYKGSEAYNKDGIVQQAVRLLKKRwPALVVVTDVCLCEYTDHGHCGLVRQgd-tsGEVHNDPTLSLLTKAAVS 158
WP_041695809  83 -P--REKDELSSSAYHEHGVVQEAIRAIKAEnPDLVVMTDVCLCEYNPLGQCGLVRD-----GKIVNDPTLELLAKTAVS 154
WP_015255411  82 -P--EHKDEIGSSAYDPNGIVQEAIREVKRLaPDLVVAADTCLCEYTDHGHCGIVRRtpsggADVANDESLELLAKTAVS 158
WP_087458665  83 -P--DHKDDCSSQAYAEEGIVQKAIRVAKEEnPNLVITTDVCLCQYNPAGHCGIVEN-----GEILNDPSLELIAKTALS 154
WP_123041306  83 dP--SEKDALGACAYDEQGIVQEAIRRIKAEyPELLVVADTCLCEFTDHGHCGVVHDhg-gvAVVDNDESLKLLVQTAVS 159
1W5O_A       164 HAEAGAQVVAPSDMMDGRIGAIREALESAGHTNVRVMAYSAKYASAYYGPFRDAVGSASNLgkGNKATYQMDPANSDEAL 243
WP_015774560 155 QAQAGADIIAPSDMMDGRVAAIREALDEKGFLDTPIMSYAVKYSSAFYGPFRDAAESAPKF--GDRKTYQMDPANWREGL 232
WP_015752381 156 HAEAGADIVAPSDMMDGRVQAIRLALDTAGFQQTPIMSYAVKYASAFYGPFREAAESAPQF--GDRKTYQMDPSNAREGL 233
WP_013074709 152 HAAAGADLVAPSDMMDGRVKMIRSALDERGFEHVPVMSYAVKYASAFYGPFREAADSAPQF--GDRRSHQMDPANRREAI 229
WP_013515123 157 QARAGADMVAPSDMMDGRVAAIRAALDDAGFLNTPIMAYAVKYASAFYGPFREAAESAPQF--GDRKTYQMDPPNGREAM 234
YP_010077    159 HAEAGADIVAPSDMMDGRVQAIRAGLDANGFSHIPVMSYAVKYASSFYGPFREAAESTPQF--GDRKTYQMDPANSREAM 236
WP_041695809 155 HAQAGADIVAPSDMMDGRVAAIREALDARGFEDVIVLSYAVKYASSFYGPFREAADSAPQF--GDRKSYQMDPANGREAM 232
WP_015255411 159 QADAGADIIAPSNMMDGFVSAIRGALDAAGHESVPILSYSVKYASAYYGPFRDAAQSAPQF--GDRKTYQMDPANVREAL 236
WP_087458665 155 HAQAGADIVAPSDMMDGRIAAIRHTLDQNGYLNVPVISYAVKYSSAYYGPFREAAHSAPAF--GDRKTYQMDPANSREAM 232
WP_123041306 160 QAQAGADIIAPSNMMDGFVAAIREGLDEAGFVNVPIMSYSVKYSSAYYGPFREAAQSAPQF--GDRKSYQMDPGNAREAL 237
1W5O_A       244 HEVAADLAEGADMVMVKPGMPYLDIVRRVKDEFRAPTFVYQVSGEYAMHMGAIQNGWLAE-SVILESLTAFKRAGADGIL 322
WP_015774560 233 REAAADVEEGADILMVKPGLPYLDIIRLVRDNFDLPVAAYQVSGEYSQIKAAGQNGWIDEtAVALESLIAFKRAGADLIL 312
WP_015752381 234 REAEADTAEGADFLMVKPALAYLDILSQLRQRSTLPLAAYHVSGEYSLIKAAAQQGWIDEqAVALESLTSIKRAGADLIL 313
WP_013074709 230 REARSDLDEGADVIMVKPAMAYMDIIRDLRERLDVPVAAYQVSGEYSMIKAAGLRGWIDErAVVLESLLGLRRAGADLII 309
WP_013515123 235 REAAADLMEGADILMVKPGLPYLDIIRQVRDAFDAPVAAYQVSGEYSMIKAAAANGWIDErAVVMESLVAFKRAGADLIL 314
YP_010077    237 REAAADVDEDADFLIVKPAGPYLDIIRQVRDNFDLPVVAYQVSGEYSMIRAAGINGWINEeAVIMESLLGMKRAGCDLII 316
WP_041695809 233 REARSDLEEGADMLMVKPALSYMDVTARLRAAFDVPIATYNVSGEYSMVKAAAQHGWIDEkAVVMEMMTSFKRAGADLIL 312
WP_015255411 237 REAESDVLEGVDMLMVKPALAYMDVIRTIKDNFDLPLAAYNTSGEYAMVKAAAMNGWIDErAVVLETLTGLKRAGADLII 316
WP_087458665 233 REAASDVAEGADMLMVKPALAYMDIIRQLRDTWDLPIVAYNVSAEYAMVKAAAQNGWIDErALVMETMTGFKRAGADLIL 312
WP_123041306 238 REARSDVEEGADFLMVKPGLAYLDIVRALRERFDLPLVVYNVSAEYSMVKAAAMQGWIDEkAIVLETLLGMKRAGADLII 317
1W5O_A       323 TYFAKQAAE--QLRR 335
WP_015774560 313 SYFTQDLLKagHI-- 325
WP_015752381 314 TYFAEQALD--WLS- 325
WP_013074709 310 TYFAKDVAR--WLRE 322
WP_013515123 315 TYFTEDVLK--TLK- 326
YP_010077    317 TYFTEELLAkgLVr- 330
WP_041695809 313 TYHAPDVLR--WLRE 325
WP_015255411 317 TYHAIDAAN--WLKA 329
WP_087458665 313 TYFSKDIAG--YLKA 325
WP_123041306 318 TYHAKDAAR--WMNG 330
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