2XUE,5FY7,5KR7,3OPW,5V9P,5YKN


Conserved Protein Domain Family
JmjC
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pfam02373: JmjC 
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JmjC domain, hydroxylase
The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.
Links
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Statistics
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PSSM-Id: 396791
Aligned: 30 rows
Threshold Bit Score: 93.1317
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2XUE_B  237 QLYMKVPGSRTPGHQENNNFCS---VNINIGPGDCEWFAVHEHYWETIS---AFCDRH-G-------VDYLTGSWWPILd 302  human
Q19565  757 QMYAKPIGSRTPAHMENSLMAS---INWNRGPGTCVWFAVPYEYWGQLE---FMIGEH-G-------HKYQDQDYWPSEk 822  Caenorhabditis elegans
Q19760  611 QVYCKPPGARTTAHLENQALGS---ININHGPGDCVWYGVPMEYSGRME---VLIKKH-R-------LNVYKSGYWPSEq 676  Caenorhabditis elegans
O97101  150 LVYIGSNGTYTPGHIDMCGSLSqnlMVSSDQDAFAWWFIVPTEYKDEAL---KFWGDKgg------dVYNESRFIRPID- 219  Dictyostelium disco...
Q9VJ97  199 FVYMGPKNSWTSYHADVFGSFS----WSTNIVGLKKWLIMPPGEELKLN-------DR---------LGNLPFSIDEKM- 257  fruit fly
Q5R6G2  174 WFVMGPPRSGTGIHIDPLGTS----AWNALVQGHKRWCLFPTSTPRELI---KVTRDE-GgnqqdeaITWFNVIYPRTQl 245  Sumatran orangutan
Q9VD28  179 WFVMGPARSGTGIHIDPLGTS----AWNTLIRGHKRWCLFPTQTPKELL---KVTSAMggkq-rdeaITWFSTIYPRTQl 250  fruit fly
Q9WTU0  236 YCLICVKDSYTDFHIDSGGAS----AWYHVLKGEK---IFYLIRPASAN---ISLYERwrsa-snhsEMFFADQVDRCYk 304  house mouse
O04698 1458 KDSLSNNSCQDDVHLGTQNGS----AVWDIFRRHDVPKLTEYLKKHHREfrhIINLPVnSvihpihdQILYLNEKHKKQl 1533 pea
O13977  225 FAYLGSHLTTTGLHTDVYASHS----FSVNLCGVKCWLFIDPKDLQTIA---SLYDDQq--------LPSWITKDDLFRg 289  Schizosaccharomyces...

2XUE_B  303 dLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNV 345  human
Q19565  823 eLLELGVPVIKFEQKADEMVYVNTGCFHWVQSNSFCINVSWNV 865  Caenorhabditis elegans
Q19760  677 eLRNEKIPSQKFLQKPGDMVYVGIGTFHWVQSNDFAINVSWNV 719  Caenorhabditis elegans
O97101  220 -LLGAPFPIYVFKQRPGDFIFVPPDSVHQVVNCGPGISTKVAW 261  Dictyostelium discoideum
Q9VJ97  258 -LDEHNVRYYTINQRANEAVFVPSGWFHQVWNLTDTISVNHNW 299  fruit fly
Q5R6G2  246 pTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNF 288  Sumatran orangutan
Q9VD28  251 pSWPEQYRPIEVLQGAGETVFVPGGWWHVVLNMDDTIAITQNF 293  fruit fly
Q9WTU0  305 -----------CTVKQGQTLFIPSGWIYATLTPVDCLAFAGHF 336  house mouse
O04698 1534 kLEYG-VEPWTFEQHLGEAVFIPAGCPHQVRNRKSCIKVAMDF 1575 pea
O13977  290 pLVNHRHLIKILFQYPGQTVFVPSGWYHQVLNIGTTLSINHNW 332  Schizosaccharomyces pombe 972h-
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