Conserved Protein Domain Family
cREC_REC

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pfam20274: cREC_REC 
Cyclic-phosphate processing Receiver domain
This is a divergent version of the Receiver (Rec) domain linked to different NAD+/ADPr-processing enzymes. Unlike conventional Rec domains, cREC is never found in two-component Histidine Kinase signalling systems. Instead, it is found in association with NAD+-processing systems that generate or recognize cyclic nucleotides. Known Rec domains process phosphoester linkages by means of catalytic aspartate residues that are also conserved in cREC. Accordingly, it is predicted that these are cADPr or 2_-3_ cyclic nucleotide-processing enzymes.
Statistics
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PSSM-Id: 466424
Aligned: 189 rows
Threshold Bit Score: 37.1112
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ALO80216   5 RLLWLDDYRDPe--------dKt---TDW------MVfsclgrdcevfwVKSYDEFKDWI-----T-E--NGLP--DgIN 57 
TQV76031   1 MELLIDATRTY---------------SVD------KV------------TRCVQQGKRAL-----R-E--MPVE--T-LY 36 
ANN87157 172 TNILIDDVRDL----------P----EMS------II------------CRTVIGALELS-----D-I--FSFTgsY-LF 210
AGN30352   1 MYVLIDDLRDInkl-----taDtvreDEK------LV------------LRTYKEGMKFI-----KhTnlTDIT----LF 48 
KDR36731   3 TILIIDD-DDAfreglaetvqD----LGY------SSs----------eARSGDEAFEQL-----R-G--RSAP--DcIF 51 
AFQ22244   2 LHILFDDVRNL---------------EGMd-----II------------ARTTEAMHSLI-----ElHliKGC---Y-LY 40 
ASU03059   3 FHILIDDVRNL---------------HGMd-----II------------IRTPEAAVEFL-----N-K--TDTTghF-VY 41 
QCW23809   4 LHILIDDVRNL---------------NGMd-----II------------IRTPVVALDYV-----R-N--NETTghV-LY 42 
BBU72672  12 MFLWLDDNRKP----------P----EYVistgktYW------------AHDRDTFMKCI-----N-NhmKEIK--E-VS 56 
AUE23365   1 MIIWLDDLRDPk-------------dYGYpd---aLW------------FKTSQKFMDFLdnrskF-Y--RYVT--E-WH 46 
ALO80216  58 FDHDLEdahytpeeywddytkskeyqdaqNHEKTGFHCA-KWLVDYLIdnnk-------------klpK---WSSHS-AN 119
TQV76031  37 LDHHFG------------------------ERETGSDII-RWARERHll-----------------pkQ---VVLVT-AS 70 
ANN87157 211 MDSDLG-----------------------DPEVQGKDLL-DHILFLGq--------------------RplkVVLVT-SN 245
AGN30352  49 MDNDLGd----------------------ALGHEGYHIL-SHAIDHGny-----------------pkT---VILVT-SN 84 
KDR36731  52 LDFRLP-------------------------GADGLAVL-ETLRKTPGlqtvpvvmltahatsdntigAmrlGAFEHlTK 105
AFQ22244  41 MDNDLG------------------------ASEEGYDILtTILTKTDn--------------------RpayVHLVT-SN 75 
ASU03059  42 MDNDLA-----------------------VDGMEGYQIL-RLLLEFGq--------------------RpkkVVLVT-SN 76 
QCW23809  43 MDNDLSs---------------------nPKDPEGQHIL-RQLLDWGq--------------------RpkkVVLVT-AN 79 
BBU72672  57 LDNDLGik--------------------dFEGKDAFLII-EALLYSNnl------------------nNlktIYIHS-HN 96 
AUE23365  47 FDNDLGe----------------------DSEKEGYDCL-LALEEKLVygk--------------lpvHdakLYVHT-SN 88 
ALO80216 120 PVGRDNINNYLFN 132
TQV76031  71 PRGRSDMAQLLRD 83 
ANN87157 246 PVDAEYMRGTLTS 258
AGN30352  85 PVAHTKMARLLMN 97 
KDR36731 106 PVGREEIAALLER 118
AFQ22244  76 PVARIRMQQLLEA 88 
ASU03059  77 PVAKETMRNDLLD 89 
QCW23809  80 PVAAQNMREDLKD 92 
BBU72672  97 SSAVDYMYSAKDS 109
AUE23365  89 PSAAQKFMLAKES 101
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