1D2T


Conserved Protein Domain Family
PAP2_acid_phosphatase
?
cd03397: PAP2_acid_phosphatase 
Click on image for an interactive view with Cn3D
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.
Links
?
Statistics
?
PSSM-Id: 239491
Aligned: 29 rows
Threshold Bit Score: 139.778
Created: 29-Apr-2005
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1D2T_A: bound sulfate marks the phosphate binding site of Escherichia blattae non-specific acid phosphatase
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
1D2T_A       1 LALVATGNDTtt-------------------------------------------------------------------- 12   Escherichia blattae
NP_695256   28 LAATPAIAQAdq-------------------------------------------------------------------- 39   Bifidobacterium ...
CAI37740    18 TMSLSAVNVApveaapsv-------------------------------------------------------pavagse 42   Corynebacterium ...
AAU24325    13 LIAVCTLALLlsspivsdasp--------------------------------------------------atkpttads 42   Bacillus licheni...
NP_535044   22 LLVFVQGAAAfdsngpagqgyaiavpepvasyplpladnyrnq-----tgknakgedvrayddrdnpiieilsgfnriwt 96   Agrobacterium tu...
AAL22455     6 TVLASSLALAmpalakdiplsqaesiaksvtpdsasvafndleaqwltqlrkalqgdtaaltrdalaqmrqnsiqadnaw 85   Salmonella typhi...
YP_045680   93 SLFVDAGVSA---------------------------------------------------------------------- 102  Acinetobacter sp...
YP_056656    7 SVLGLACATAlvssvgv---------------------------------------------------------spaqaa 29   Propionibacteriu...
NP_600418   79 TNVSTDLNPSs--------------------------------------------------------------------- 89   Corynebacterium ...
CAA18915  1784 TSATSTGDPAeyepspfp--------------------------------------------------------gdtlda 1807 Streptomyces coe...

Feature 1                                                                                      
1D2T_A      13 kPDLYYLkn------------------------------------seAINSL------------------ALLPPPPAv- 37   Escherichia blattae
NP_695256   40 lPNPDWVallsdye---------------------------knywqaPTDAEhggkv--------lhadtMKLDEDLAva 84   Bifidobacterium ...
CAI37740    43 gLPSYPHpvqh--------------------------------kgapTPQPFgpeylggyisdisshgygVYLDVVDGfn 90   Corynebacterium ...
AAU24325    43 pQSSGFFvdhyknnisanttaesnpvigllsefnklwtpgktwntgtKLNSRvld-------------anIQKVVDIA-- 107  Bacillus licheni...
NP_535044   97 lGDEKWVdgga--------------------------------nsdgPPDFShv---------------rIVDPAVWQen 129  Agrobacterium tu...
AAL22455    86 lQASGYDf--------------------------------------hTTENQqm--------------giTLLSAFNTl- 112  Salmonella typhi...
YP_045680  103 -EARDGFpavkas-----------------------------nwtgiPGDSTdgtk-----------knsDVLNYNIHys 141  Acinetobacter sp...
YP_056656   30 qPDESADphvalls---------------------------eydrywTPKPFdkqn----------fdtaFRGDVTPQgs 72   Propionibacteriu...
NP_600418   90 nAAVGVLeeml---------------------------------elwTPGEEwntgv---------kvdpTVLDSNIAqs 127  Corynebacterium ...
CAA18915  1808 tYASDAWpet-----------------------------------gdGSDWFthll----------sgfdDLGPATLGan 1842 Streptomyces coe...

Feature 1                                                                                      
1D2T_A      38 ---------GSIAFLNDQAMYEQGRLLRNt----------------ERGKLAAEDAnls------------------sgg 74   Escherichia blattae
NP_695256   85 -------inHKAAENLDKDGLNAQRKRALvd-------------sdLQAEEAMPDAlg---------------------p 123  Bifidobacterium ...
CAI37740    91 dv---ranhPGIMKQNLDKVVNINNAVQDn---------------pAAIQRAQKDArad------------------kag 134  Corynebacterium ...
AAU24325   108 ---------ERRTMLEENAAYFDDRRSQSysiidgl---gklagvyRMNAGATTTItsipa--------------dasir 161  Bacillus licheni...
NP_535044  130 mryvlsvtgDNRTRAAAFEAYMNDRRSQGysvidgm---gpladwyREGAGATTTInhtlad-------------fdpnd 193  Agrobacterium tu...
AAL22455   113 ---------PEAVLKDNLATVTAINHDADv----------------NTRHQALADAesveylyf--------lsdamgpr 159  Salmonella typhi...
YP_045680  142 v-----qttHNRTADDAIRAYLDDRRGKSysvttg-----lgaltdPWRKLTGQTTtinavpsd--------aqqvkydd 203  Acinetobacter sp...
YP_056656   73 ki---larnDEGVEQINKAGVDEANQAADrqgrs-------qqwraLRDATMFTDPlqedndslgpvlskyvaeglaqct 142  Propionibacteriu...
NP_600418  128 v-----aisQQATDAQQERAWVIDRRNQNytatdglgayadsyretAQVGTTIPDVvpadattv--------kyndggnv 194  Corynebacterium ...
CAA18915  1843 se----vpaGTPLGAENDRITVSVNNAATq----------------QQVDRAEVDAsnsa-----------------tvt 1885 Streptomyces coe...

Feature 1                                                            #      #                  
1D2T_A      75 VANAFSgafgsp-------------itekdaPALHKLLTNMIEDAGDl-aTRSAKDHYMRIRPFAFYGVSTCNTteq--- 137  Escherichia blattae
NP_695256  124 VLGKYMseg-------------------lksGKLNAVADIFSFNVAS---TYASKRAAMHPRPYLNRAESSYGGtndlag 181  Bifidobacterium ...
CAI37740   135 VLDAFSdslgtelgrhfrdalrenrlpktqfLLGNGYLARAGGVASS---TFVEKVVFNNDRPFVVAPERIKKYedgq-- 209  Corynebacterium ...
AAU24325   162 KYNDEGtnsg------------------stsSELGNVVSLVNTLRGNyssSNPAKSYFNYPRPFRWKDNSIIVPtlipv- 222  Bacillus licheni...
NP_535044  194 VIIRKEddkgte--------------agaadSELKDFVAFMKVIRGPegtTSPAKYFYSTPRPWRMNDKGEVIEtgkemi 259  Agrobacterium tu...
AAL22455   160 LGRAFLaay--------------------dkGELGKAAALIKASEVS---TGAAKKYFHYPRPYQVPGNTIHLTpddvvv 216  Salmonella typhi...
YP_045680  204 QGNNSGltta------------------egnTDFGLVVEFVKSMADNa-sTEPAKRFYKYARPYRWSSDVIVVPslesa- 263  Acinetobacter sp...
YP_056656  143 PANVHScs----------------------lTHVARFLWSTGFQEVTnksTGPAKKYFNYPRPYLADRSFADSGnpnnlr 200  Propionibacteriu...
NP_600418  195 NGNWAEtgg--------------------elGSTVDLIEAIRQHAAT---SNNAKAYYQYPRPYRWTESIEPEAwgegvd 251  Corynebacterium ...
CAA18915  1886 MADGLGsrlgplyg---------ealkegrlPKTSALFSRVNENLDT---HDAAKNHYQYLRPYVRLGFAGDGGavyesq 1953 Streptomyces coe...

Feature 1                                                       ###                            
1D2T_A     138 ---------------------------------------dkLSKNGSYPSGHTSIGWATALVLAEINPQRQNEILKRGYE 178  Escherichia blattae
NP_695256  182 lpatldik-------------------qspswlehvpgysnLQKNSSYPSGHTTGAYSWGIALAGMIPELAPQIMARTSE 242  Bifidobacterium ...
CAI37740   210 --------------------------------------nkyYGTSKSYPSGHTNQAVWSTTLLALTLPELAPQILARGSE 251  Corynebacterium ...
AAU24325   223 -------------------------------------inpdPNKDGGFPSGHTNAAYLSAFAMAYAIPERYQELLTRASE 265  Bacillus licheni...
NP_535044  260 gdrsfesydsd--------------pgvivpalkyarenrgRAKDGGFPSGHTNAAYLAAIAYAYAVPERFSELLTAASE 325  Agrobacterium tu...
AAL22455   217 -----------------------------------kdghpyTAGGGAFPSGHTNTGYTDALLMAEMIPERFDALVIRGAR 261  Salmonella typhi...
YP_045680  264 -------------------------------------ksstPATDGGFPSGHTAEAGRNAIAMAYLIPQRYQELIARAMD 306  Acinetobacter sp...
YP_056656  201 glkknlaiarvpsridvnhkrggralltagydlmdgasgtnLTVSQAFPSGHTTAAYAYGLAMAEILPELGPEILTRASE 280  Propionibacteriu...
NP_600418  252 mpey---------------------------anplrkdeseAASDGGFPSGHTSAGGMATNGLAYAFPQQYDKLLMTAAE 304  Corynebacterium ...
CAA18915  1954 -----------------------------------dssysgLAGQGSYPSGHTYGGYEAGTILATLLPDLAPSILARTSE 1998 Streptomyces coe...

Feature 1          #     #   #                                     
1D2T_A     179 LGQSRVICGYHWQSDVDAARVVGSAVVATLHTnp----afQQQLQKAKAEFA 226  Escherichia blattae
NP_695256  243 AGNNRIVLGVHYPLDIMGGRIGASAQNGQYWHne-----fASSIVPASRQLR 289  Bifidobacterium longum NCC2705
CAI37740   252 AGNNRIVMGVHYPLDVMGGRMSGTAAAADRWNdp----kmRDAIQQAGKELR 299  Corynebacterium jeikeium K411
AAU24325   266 LGHNRIVAGMHSPLDVMGGRVMATALSAAILSdpanerlkKTAFDEARRKLL 317  Bacillus licheniformis ATCC 14580
NP_535044  326 LGESRIVAGMHSPLDVIGGRITATAMAAAMLQdpknaevkKAAHDAVEAYFA 377  Agrobacterium tumefaciens str. C58
AAL22455   262 YGYSRLVLGVHYPLDVMGARMVAQRNVAHYLNdp----yyRTLFNEARAQLR 309  Salmonella typhimurium LT2
YP_045680  307 LGNSRIIAGMHSALDVVGGRIQSIAADVANLNamtp-ekrQQAYQQAQTQLM 357  Acinetobacter sp. ADP1
YP_056656  281 AGNNRAVLGVHYPMDIMGGRIEGHSNVSAALTtnr---lyVASLKAARTEVM 329  Propionibacterium acnes KPA171202
NP_600418  305 IGESRIQLGMHSPLDVIGGRVLSTAITAGALNdpnldsvkAEAFDDAQAWIS 356  Corynebacterium glutamicum ATCC 13032
CAA18915  1999 YGDNRIVLGFHYPLDVMGGRITAQATVAHRWAdp----efAKLLGQAHTEIE 2046 Streptomyces coelicolor A3(2)

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap