Conserved Protein Domain Family
SANBR_BTB

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pfam11822: SANBR_BTB 
SANT and BTB domain regulator of CSR, BTB domain
Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR.
Statistics
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PSSM-Id: 432102
Aligned: 7 rows
Threshold Bit Score: 151.861
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4DXB1        30 VEVTVYDKLLNEVRTFRCHQHLLETSMAYFEPIIRRyleeeaeeekkriraeiekgrdsisgasaatnletsigvtdgsa 109 Trypanosoma cruzi
XP_002939550 146 MVIHVCDEAKNLKEDFVCPRDLLVSEMKYFAEYLST-------------------------------------------- 181
CAG10202       1 MVIHVCDETKNLKQDFTCPRDLLVKEMRYFAEYLSV-------------------------------------------- 36 
EDO39893       1 MVIHVCDESKNLKQDFTCPRDLLIREMRYFAEYLSV-------------------------------------------- 36 
Q4Q8A2        20 VEITVQDPATHHERPFLCALGPLRTHMRYFEPLIQRqi------------------------------------------ 57  Leishmania major
CAM39711      10 AEITVQDPVTHNERTFLCALGPLRTHMRYFEPLIQRqm------------------------------------------ 47 
Q383Z9        26 VEVSVYDKQSNEMRVFRCDLHLLESSMTYFTPIIKCyldeeerqksreeksldrasst---------------------g 84  Trypanosoma brucei
Q4DXB1       110 drkaiigtrgqgdvgpssrisGNTPLPP----------IPIRVNCDLSIFSWLMAYIQG-----------KDRPFTPENA 168 Trypanosoma cruzi
XP_002939550 182 ---------------------DAQRWEE----------VDISVHCDVHIFDWLMRYVKRsape---nenqEAPKLEPGNV 227
CAG10202      37 ---------------------DTQRWEE----------VDISVHCDVQIFDWLMNYVRRntag----enkDKPRLEPSNV 81 
EDO39893      37 ---------------------EAQRWEE----------VDISVHCDVQIFDWLMKYVKKglmekgkkvdeKPPKLEPNNV 85 
Q4Q8A2        58 --------------------nEAKVSPPpesssslavaFTLRARCEHATFQWLINWISG-----------KAPQITNSNV 106 Leishmania major
CAM39711      48 --------------------sETTVWPPsaspsssavaLTLRARCDHVTFQWLVNWMSG-----------KTQEITKDNV 96 
Q383Z9        85 arsvknsktkaheatkplkrkGKEEKPP----------IPLHVNCDMSTFSWLMAYVEG-----------KQRSFTPKNA 143 Trypanosoma brucei
Q4DXB1       169 VSIALSSNFLLMTQLVDLPL 188 Trypanosoma cruzi
XP_002939550 228 ISILISSEFLKMDSLVDKCI 247
CAG10202      82 ISILISSEFLKMDTLVEECI 101
EDO39893      86 ISILISSDFLKMDNLVNDCI 105
Q4Q8A2       107 VSICLSSSFLQMQELSDNAL 126 Leishmania major
CAM39711      97 VSICLSSSFLQMQELSDNAL 116
Q383Z9       144 VSLALSSNFLHMTQLVEMTL 163 Trypanosoma brucei
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