Conserved Protein Domain Family
DUF4825
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pfam16107: DUF4825 
Domain of unknown function (DUF4825)
This domain forms the N-terminal, extracellular domain of some homologs of Staph BlaR1 proteases, where it replaces the penicillin-binding domain of BlaR1. It is also found in many uncharacterized proteins in a broad range of bacteria. Its association with BlaR1 homologs suggests it may be involved in substrate-, possibly antibiotic-binding, but this prediction has not been verified experimentally.
Links
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Statistics
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PSSM-Id: 435140
Aligned: 30 rows
Threshold Bit Score: 70.3677
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_054329563   384 LYDARTPYIGGASDVGKILGLLPLPNGLTYHeeGMELFTDEgSPFGakQHLMFTEATTEAEKQAlls------ntdQLER 457  Clostridia b...
WP_008392698    33 LSQYKTDYVGDSSNVINIVSGQEYPEGYSYD--SIEIQSET-EPYG--LTVFLKDEPSAVKLED------------ELQV 95   Eubacteriales
jgi:Ccel_0433   57 LFENKTPYVGNNSKVLHIIDNLQFGNYRG----EVSLQTEK-IPYG--VTVNYDFQNLVKEDYQkakieneerlklAFKR 129 
jgi:Dtox_2059   49 LYKYKTPYVGDNSKVVHLIDSLPYANLRK----NVLLQTQV-VPYG--VTVDYDFSSAHKEPQQme---------tYFQN 112 
MA:Aflv_0291    41 LFSYKSQYVGDVSNVSGLLDQLAFGTYRR----SVSLQTVK-EPYG--MTVHYDMENTEMGLKKie---------kLLYD 104 
WP_012103824   330 IYKYRTPYVGDNSKVLNIINSLPVPETLHHR--KIQLFTDK-KPYG--IQITYETTNDVKESFLrke------nqlIFDE 398  Clostridium ...
BAK98461       328 LFEYRTAYVGDDSSVGNIVGLLEFPSDVSYD--HIELQTSA-EPYG--VEVYFSVTSEVKAAYTtses----dsmdVLRE 398 
WP_003516157   324 LLKNKTEYVGDNSKVGGIIFLLKFPKNVSYD--FFELFTDK-EPYG--VNINLKTDTETKNLYVgee------nrqQFQS 392  Acetivibrio ...
CDI40980        63 FLEYKTEYVGDASKVGNIIRLLKFPEKVKYD--HFELHTEN-VPYG--ITVHLKTDTQTKNFYTganla---lnqtPFEK 134 
WP_015881085    24 aFEYKGAKVGDNAAVVGIAGSLPLHECYR----SVELQTKK-RPYG--LTVRYEDPGMERAEQEhl-----------aIR 85   unclassified...

WP_054329563   458 NAYLFLALVDNADFLEYKihd----tpTTESVT 486  Clostridia bacterium UC5.1-1D10
WP_008392698    96 NADMTFDLIGNLGTIDYKta-----dsKEIIVS 123  Eubacteriales
jgi:Ccel_0433  130 NAAMMFCLIENLDKITFVcrtv--kgtAEYGFT 160 
jgi:Dtox_2059  113 NAIILFALIENIDEVTFItr-----giGKYPKY 140 
MA:Aflv_0291   105 NAVILFVLIENLDRITFDmnvdakhvsYSFere 137 
WP_012103824   399 NAAIIFSLVGNADYIDFVlk-----teGQFDRT 426  Clostridium kluyveri
BAK98461       399 NACIMFSLIGNADEITFRlddg-tenpVDLQFT 430 
WP_003516157   393 NAVIMFSLIGNVEYISFTlddg--lepYSIRYT 423  Acetivibrio thermocellus
CDI40980       135 NAIIMFSLIGNVDYINFNltdg--kndYLIQYT 165 
WP_015881085    86 NAAAYFTLIPNAEIVRFAfp------nRTYAFS 112  unclassified Exiguobacterium
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