2IV3


Conserved Protein Domain Family
GT4_AviGT4-like

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cd03802: GT4_AviGT4-like 
Click on image for an interactive view with Cn3D
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins
This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.
Statistics
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PSSM-Id: 340832
Aligned: 25 rows
Threshold Bit Score: 261.838
Created: 6-Dec-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               #                                                     
2IV3_A      5 KVALVNIPLrvpgsdawisvppqGYGGIQWVVANLMDGLLELGHEVFLLGApgsp-----agrpGLTVvp---------- 69  Streptomyces virid...
EDN35495    2 NIVQICPAIvp----------vnNYGGTERVIYWLSGALAELGHQVLLIAPkgsy-----hqntNVKIie---------- 56  Francisella tulare...
BAC18283    2 KIAVVAPGRhpi--------vepYPGGLEAYCGILVQGLRRQGHEVDLYAAagsh-----ghvrDFEFptvdwasnpleq 68  Corynebacterium ef...
CAD73721    2 KIGIIGHLKfpi--------akpYAGGLEAFTHAYTNALKNRGHEVTLFASgdsd-----pqlpLQSIipnatipeshar 68  Rhodopirellula bal...
AAX11431    2 KILHVLLTRmpi--------pptKYGGTERVLWALYQGQTALGHQVRFLLKan---------anHAPYvq---------- 54  Moraxella catarrhalis
ABA02570   36 KILHVLLTRmpi--------pptKYGGTERVLWALYQGQTALGHEVKFLTKhdn--------khPDALv----------- 88  Moraxella catarrhalis
NP_924833   6 RLLFVSSALgpl--------gtgMAGGVEFNVLTLAAELIRRGHLVHIVAPegsht----gavpLVAAipglppasaqht 73  Gloeobacter violaceus
NP_875685   7 RLILISTPIgfi--------gsgKGGGVELTLVAIIKGLLEMGHHIVLVAPygsfl---psgceGAEIitvkgidqsswq 75  Prochlorococcus
ABE10959    7 RIVLISTPIgfl--------gsgKGGGVELTLNSLVSGLISLGHSVEVVAPknsklhesnvrakLHFVegedqiswq--- 75  uncultured Prochlo...
AAK70860    5 RFLFVSTPVgpl--------gsgRGGGVELTLPNLAKALTQRGHQVSVLAPagsvl----pdlpLETVpgtwqstaqshg 72  Synechococcus elon...
Feature 1                                                                                     
2IV3_A     70 ----------------aGEPEEIERWLRTad-------vDVVHDHsggvigp---------aglppgTAFISSHHfttrp 117 Streptomyces virid...
EDN35495   57 ----------------cEDFSNLAKVIPKn--------vDIVHIHdinyi------------nqvksFRWLLTIHgndkr 100 Francisella tulare...
BAC18283   69 t---dhtyppghgdkedAAFARLRTHLETsd-------yDVVHNNslhpel-----------lrsevLPLITTLHcppvd 127 Corynebacterium ef...
CAD73721   69 l---grmchdwiesvedEAYAALMLQLSTsd-------fDVIHNHslspipl--------qfshllpTRLMTTLHapalp 130 Rhodopirellula bal...
AAX11431   55 ---------------vfDKSKPLHEQIDDw--------aDMVHFHfpye--------------gelhKPFVCTEHsnsev 97  Moraxella catarrhalis
ABA02570   89 ----------------fNPNISLEKQVEGw--------aDIIHFHflyr--------------geitTPFVCTTHnqqit 130 Moraxella catarrhalis
NP_924833  74 g----rdspvvlpqpsaLANLFEAARARQdd-------yDVIFNWcydwlpl--------yltpffrTPLAHMITmgsll 134 Gloeobacter violaceus
NP_875685  76 hqvpdapitipfngmlpKLVEVALKVSKNs---------DAILNLcydwl-------------plwlTPFVEPKIfhlis 133 Prochlorococcus
ABE10959   76 ---------hqnynspvSIPDNSLLVGMLekglniakhaDVLLNMsydwlpiwmtl-nleipiahiiSMGSESSVisnli 145 uncultured Prochlo...
AAK70860   73 r---atpaeipaesvlaRLWDRAHQQQADf---------DLILNFaydwlplyltpffktpvahlisMGSLSEVMdqaia 140 Synechococcus elon...
Feature 1                                                                           ###       
2IV3_A    118 -----------vnpvGCTYSSRAQRAHcgg---------gddAPVIPIPVDPAryrsaadqvakeDFLLFMGRV-SPHKG 176 Streptomyces virid...
EDN35495  101 av------fnneypeNIVGVSRNHAVAhn------------lRHYVYNGVDSKefifn---pnkqDHFLFFSKVsYRAKG 159 Francisella tulare...
BAC18283  128 rmv----eaaptsrsLFTAVSHHTARSwd-----------lpGTRVIPNAVDVdvwqv---gpggDNAVWFGRL-VPEKA 188 Corynebacterium ef...
CAD73721  131 rmaaelrrrggdacgQFINISNANADAwrsl--------lpeQTVIHNGVDTSfwvrc--keqkqRRAIWFGRI-LPDKG 199 Rhodopirellula bal...
AAX11431   98 e---------kefpiNTIYLSSKHAENnh------------aTCYVHNGLYWPdygep--nfkpkDYCHFLAKAsWRIKN 154 Moraxella catarrhalis
ABA02570  131 pa-------sfpkntIFLGKLHAQRSGg--------------QAYVHNGLYWAdygqpn-lnmpkNYVHFLANAkYKDKN 188 Moraxella catarrhalis
NP_924833 135 esidrqivrvletfpGTVAVYTRSQAEtfap--------iegLTVLPFGLDPAsydfcp-tpdaePFLAWVGRI-APEKG 204 Gloeobacter violaceus
NP_875685 134 magv---sklmeatvRDLSKTHHSRLAfhtfsqasdyelidqPIVLGNGFDLKnyhfq---lkgqGPLGWAGRV-APEKG 206 Prochlorococcus
ABE10959  146 sk------vyakypnNFAFHSKMQANDypf---------ikkPTIIGNGFNLDnyifq---dsvkGPLAWVGRV-APEKG 206 uncultured Prochlo...
AAK70860  141 t--------sldrypGSIAVHSLAQAAtfpf--------gdrCLCIGNALDLAaygfn---pepePVLGWVGRI-APEKG 200 Synechococcus elon...
Feature 1                                                                   #                 
2IV3_A    177 ALEAAAFAHACg--rRLVLAGPaw--------ePEYFDEITRry---gsTVEPIGEv-gGERRLDLLAs-AHAVLAMsqa 241 Streptomyces virid...
EDN35495  160 VDQAIKVCCKSd--vKLEIYGGdrkk----llrNPKSFLLSFk-----kNINIRGYa-tGQKKAQVFSq-AKALLFPi-- 224 Francisella tulare...
BAC18283  189 PHLAIDACRRAg--iPLTLIGRra--------nPDYFEKEVAprl--ggDIQWAGPl-tHQQLADHVRh-ARVAVITp-- 252 Corynebacterium ef...
CAD73721  200 THLALRAAHRAg--iPLDVVGPis--------dQNYFDSEVLpll--rpDDAYHGHr-tHEELCTLISr-SAVTLVTp-- 263 Rhodopirellula bal...
AAX11431  155 LQGAVRIAKKAn--kPLHILGGnrf-----nirRNPYCYLSS-------RLHFHGMv-gGVKKNELIAn-SQALIFPv-- 216 Moraxella catarrhalis
ABA02570  189 LKDSVTIARQAg--rPLHVIGSkryslkykagkYQPYYYQGA-------DLTFYGMl-gGDKKNEVIKn-SSALLFPv-- 255 Moraxella catarrhalis
NP_924833 205 LEDALAVAAACn--lPLHLLGRm----------QDAAYFERVcalhptaRVHYEGFf-pTDQMQHRLGp-ALGMLFTp-- 268 Gloeobacter violaceus
NP_875685 207 LEDAAKVAADLg--dKLFVWGLie--------dKAYASKIESlvp--egTIEWKGFl-nTQEFQSQLGs-CRALINTp-- 270 Prochlorococcus
ABE10959  207 LEDAVYVASQLgeklKVWGFIEd----------EMYASKIEKsfp--qgAIDWMGFl-sTDELQKELGkcRGLLNTPk-- 271 uncultured Prochlo...
AAK70860  201 LEDAIQAAQQAglplRVWGALTe----------PDYWQRLQQqf---gdRAVSYQGfvsTDELQRGLGrcQGLLMTPk-- 265 Synechococcus elon...
Feature 1                    #                                                                
2IV3_A    242 vtgpwggiWCEPGATVVSEAAVSGTPVVGTGNGCLAEIVPs--VGEVVgygtdfapDEARRTLAGLPasdeVRRAAVRLW 319 Streptomyces virid...
EDN35495  225 -------qWSEPFGLVMVEAMMSGTPVIALNRGSVSEVVNf-eSGFVVny-----lEQMVDAIKKIDt---IDPYKCRQY 288 Francisella tulare...
BAC18283  253 -------vWDEPFGLVSVEAMACGTPVAAFARGGMADVLRa-sPCPAVpag---dvGALARAIRNSSr---ISRAQVARF 318 Corynebacterium ef...
CAD73721  264 -------cWDEPFGLVVAESLACGTPVAAFNRGALPELIGk-sTGRLAkpg---svRELAQAILGCMk---VPGEICRRV 329 Rhodopirellula bal...
AAX11431  217 -------lWHEPFGLAVIESLYLGCPVFATPFGAMSDIVTq-eVGLLSds-----yAVLSEALKDVAq---FDRLACHEH 280 Moraxella catarrhalis
ABA02570  256 -------lNYEAFGLAMIESLYLGCPVIGSRCGSLPELIIp-eVGISTqs-----kSEMVEAIKNIAi---FNRKHCHEY 319 Moraxella catarrhalis
NP_924833 269 -------kWTEAFGNVAIEAMACGVPVVAYARGGPAETIQdglTGFLVppd---dtTAMIQAVGRLGe---IDRTACRAH 335 Gloeobacter violaceus
NP_875685 271 -------kWNEAYGNVVAEAMACGVPVVAYRRGGPGELVQsgvTGWLVpsd---diEGLKKGVLNIDk---IKRQNCRDW 337 Prochlorococcus
ABE10959  272 --------WNEAYGNVIVEALACGVPVVAYKRGGPSEIIQhgkTGYLAdpd---dkKNMLSYVEIIEk---IKRQKCREW 337 uncultured Prochlo...
AAK70860  266 --------WVEAFGNVAIEALACGLPVIAYARGGPLEIIEqgkSGWLVepd---qqAALVNAIGQLSs---LDRAYCRAQ 331 Synechococcus elon...
Feature 1                          
2IV3_A    320 Gh-VTIAERYVEQYRRLLAGA 339 Streptomyces viridochromogenes
EDN35495  289 AidNFDIAVCAKNYLQQYQRV 309 Francisella tularensis subsp. novicida GA99-3549
BAC18283  319 ArdNYGIGSFIDRYLEVYRHV 339 Corynebacterium efficiens YS-314
CAD73721  330 AqeHYSFDRMVEQYESLYQNQ 350 Rhodopirellula baltica SH 1
AAX11431  281 AkrHFSHLSMSNAYLDCYEKV 301 Moraxella catarrhalis
ABA02570  320 AqdNFNHLVMSQNYLHYYDKV 340 Moraxella catarrhalis
NP_924833 336 IetHYSLAALGGRFEAWFAEC 356 Gloeobacter violaceus
NP_875685 338 AneSASYQMFAKRINSWIQSG 358 Prochlorococcus
ABE10959  338 VekNASADIFANKVVNWLNKV 358 uncultured Prochlorococcus marinus clone ASNC612
AAK70860  332 AeaRFSLAAMGQRLEAWLLPL 352 Synechococcus elongatus PCC 7942

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