Conserved Protein Domain Family
AKR_unchar
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cd19104: AKR_unchar 
uncharacterized aldo-keto reductase (AKR) superfamily protein
This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Links
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Statistics
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PSSM-Id: 381330
Aligned: 18 rows
Threshold Bit Score: 333.078
Created: 24-May-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ###                             #    #                         
KPK07946    2 QYRRFGRSGlKVSEVVFGGGYVGGVIiladdDTRRRVLRRALDAGINWIDTAPLYGqgrSEEALGRLLAe-vDDTPYLST 80  Betaproteobacteria...
OGQ83246    2 RYRTLGRTGlKISEIGFGCGNNAVLMvratyEDQLRAVQHALDLGINYFDTAFAYGlgkSEENLGRILSe-iGASPVVST 80  Deltaproteobacteri...
PKB82061    2 NYRKLGNTGiDVSEIGFGCGDVGGLMvkgerADQVRAVARAVELGINYFDTASRYGggqSETNLGRVLKe-lSAEVYVGT 80  SAR202 cluster bac...
PKB70885    2 EYTTLGRTGlSVSRVGFGGGGIGEVWgtttqDEAVRAVHRALDLGINFFDVAPGYGdgkAEEALGLALDg-rSEDVIIAT 80  SAR202 cluster bac...
PKB77898    2 NYRELGNTGiRLSEIGFGCGGNAGLMvrgtpEQQTEAIGRALELGVNHFDQAPDYGdgiSEINLGRALKd-lGARPYITT 80  SAR202 cluster bac...
BAO92185    2 KYRSMGRTGlKVSEIGFGCGGNAGLMvrgsfDEQLRIVEAALEAGINYFDVAPDYIg--AEANLGRVLRt-lSARPLINS 78  Burkholderia sp. R...
OUV73888    2 KLRRFGRTDlQVSELAFGGGRSGGILinaneKTRRAAVRRALDLGVNWFDTAPQYGegkSEKALGWLLAe-vPEKPFVST 80  Flavobacteriales b...
OED40083    2 QIHPFGRTDlGVSRLTFGCGAVGGLMtkgraADQDRAVAWARDNGINFFDTAASYGngaSETNLGRALGg-nSNGLIIST 80  Chromatiales bacte...
OUU48840    2 KKNRFGRTEyKISQLTFGGGWVGGILidskiEVMHKALSLASKXGINWIDTAESYSegkSEENIGKLLPffdREKFYIST 81  Alphaproteobacteri...
AUT66687   16 RKRRLGRTGfEVSEISFGCGGTAGLMvrgsqQEQCAVVGSALEQGINIFDTSPTYGgghSEVNLGRTLKa-lGASPIIST 94  Burkholderia terrae

Feature 1     #                                    ##                                         
KPK07946   81 KVRLdldalsDIPGEIERSVHASLRRLkRDSVDLLQLHNQIgmrtgsgvl---gainledvLRKDGVADGLERMRKQGLT 157 Betaproteobacteria...
OGQ83246   81 KIRLepeaasDLKATTVRAVEAALRRLqRKSVDLIQLHNRVtverspgkr---fsvtpkdvLRQGGVLDGFKEMREKGKV 157 Deltaproteobacteri...
PKB82061   81 KYSLgeadpnNLKEGVIQSVEASLKRLgREQVDLIQLHDRIssqtdvt------vreitvsDVLGEVREGLEVLRSQGKV 154 SAR202 cluster bac...
PKB70885   81 KVRLaaddmaDVTGAVQRSIEKSLRLLkRDSVDVLHVHNRFtrgrgdv------phslsadDVLGPVFDAYRAVQQEGKT 154 SAR202 cluster bac...
PKB77898   81 KVEVraddlgDIAGHIVRSTDQSLQRMgIDYVDFLQLHNGPvkerpelagrsythlsledyLGPGGALEGLQRIQRSGKA 160 SAR202 cluster bac...
BAO92185   79 KVEIraenldDIADHVVRSAESSLKALgVDRLDVLQIHNAPvagarapvdrdyhtlgvqhfLGPRGTLEGLRRLIDAGKV 158 Burkholderia sp. R...
OUV73888   81 KVRIdlmsaeSLVSQVERSVAESLKRLrLDRVDLLQIHSLImpeasgr------tispnhvLCDGGVADAMAKVRDQRMA 154 Flavobacteriales b...
OED40083   81 KVGVkqqelpDAGSVVEESLNSSLKRLrLDQVDLLQLHNTIgdadrh--------gtitarQVLEDVIPAFEKQRDAGKT 152 Chromatiales bacte...
OUU48840   82 KGRLdptnseSIISQLDRKIDMSLNRLkRDYVELYQLHNRIldvgdke------nfsakdiLKKNGIADSLEKLKSEGRI 155 Alphaproteobacteri...
AUT66687   95 KIDFapgdldDLAGAISRSVERSQERLnRERLDILYLHSRVgrqrdlag----rvlsvddvLQPGGVADVMEELKRKGLV 170 Burkholderia terrae

Feature 1          ##                    #                                        #######     
KPK07946  158 RFIGLTALGd-APAIIRALDsgrFDSAQVYYNLLNPSAAramppa-wsghdFSGVCAACARHDVAMMGIRVFASGVLATD 235 Betaproteobacteria...
OGQ83246  158 GYFGFSGLGd-PRALHELIDsgeFHSFQAYYNLLNPSAGeavpqg-fsaldYGRLIDRAAEKGMGIAVIRVLAAGALTST 235 Deltaproteobacteri...
PKB82061  155 RFYGMTGVGe-PKGIHEVVAsglVSTVQTVYNLINASAGaeapar-fdmtdYDRLIDLAAEKNVGIIVIRVLAAGALTGT 232 SAR202 cluster bac...
PKB70885  155 RFIGLSAMDhdVPTLNRIMDsghWDTVLAYYNLLNWTAQelpppg-vdlfdNGQNIQLAKKHNMGVIGIRSHAAGALTAA 233 SAR202 cluster bac...
PKB77898  161 RSIGFILRGndEPAARQLIDtgaFSLINLSVNLLNPSAAmkpygm-hvgqdYGGILGYAVTHGVGAAVYSPLAGGFLNNS 239 SAR202 cluster bac...
BAO92185  159 AHVGFVCRGndAPYVRELLEsqpFGMLNVPYTLLNPSAGmalpanlavdkdGGAVLDDAREAGTGAAIYSVLARGFLSDQ 238 Burkholderia sp. R...
OUV73888  155 RFLGLTALGn-SNATIEVIEsgrFDAAQVYYNLINPSSAwtgtingwssynGNGIMKACIEQDMAIMAIRIFAASYLATP 233 Flavobacteriales b...
OED40083  153 RYLGFTAKGniEQLLELVQSg-rFDSAQVFYNLLVPSAGepfipg-ypaedYRQLLHVCADHGVGAIGVRVLAGGALSGT 230 Chromatiales bacte...
OUU48840  156 RSIGITALGd-IDGINEVVLsdcFDTAQIYYNLLNPSAAfsnlrs-wndqnFYNLINNCKLKDMGIMNIRIYAAGFLATN 233 Alphaproteobacteri...
AUT66687  171 GAIGFTGLGh-TDSILDVIKanrFDLFQAYYNLINPSAViatvaa-wraqdYGEMIAKASNLDVGVVGIRVLAAGALSES 248 Burkholderia terrae

Feature 1                                                      #                ######  #  ## 
KPK07946  236 IRHGremvlte------qsaldvETQRAQAAVAALGAGHg-------TRAQTALRFALAQSDFACFVVGLGEPSHLDEVI 302 Betaproteobacteria...
OGQ83246  236 PDAGggsspepl---spgsdyalDLQRAEKVKFLIGGNIk-------SLTAAAIRFALMKREVSTVLVGFSNVFHIDEAV 305 Deltaproteobacteri...
PKB82061  233 SVRHpvamptvap-igsgrdfqqDESRAQRFAFIVDEGFa------gDMPEASIRFALSNPGVSTVLVGYSDLDHLEKSV 305 SAR202 cluster bac...
PKB70885  234 VDRPvaedn---------hllrqDVASSAKLDFLLDGEIe-------NLSQAAMVFCLMNPNIHTTVPGVKNQAEAEEIA 297 SAR202 cluster bac...
PKB77898  240 AVAGdpphamagg-srsseareiGLRQARAVSFLSRKLNpesqredhDLAEAAFRFILSLEGVTTVLGGFSDRKQVEETT 318 SAR202 cluster bac...
BAO92185  239 SIAGeahhplardisgnasdttkMCERAARVSFLARESGi-------TLAQAAFRFVLAHPGVTTALGGFSSMEQLKELC 311 Burkholderia sp. R...
OUV73888  234 LRTGresilte------nttaekEAGSAKAVFGVLGDEFg-------TWAQTAVRFALSNQMVSTAIVGLSDQAHLDEAA 300 Flavobacteriales b...
OED40083  231 ENRHplgmpevep-igsetdyatDVQRALRFSSLITEGFa------eSLPELSVRYAISNPVLPTTEIGIATLEQLQLAT 303 Chromatiales bacte...
OUU48840  234 VRHGrevpvt-------fgidsdEIDRRVKKIELXTKHIe------gTKSQKALRYGLSNNNLSTIVIGLEKIEHLEEAL 300 Alphaproteobacteri...
AUT66687  249 GDLHrfaksyss---lsraevdaDRVKADAFRAFVPEGA--------SMANLALRFALSEPMIDTVLVGISERSHLDEAI 317 Burkholderia terrae

Feature 1                         
KPK07946  303 EAQAKGPLPAEVIARLEAVY 322 Betaproteobacteria bacterium SG8_39
OGQ83246  306 ACSGAGGLSDEAMARLKKIW 325 Deltaproteobacteria bacterium RIFCSPLOWO2_12_FULL_60_19
PKB82061  306 QYAANGPLPAEVLARLPGPW 325 SAR202 cluster bacterium MP-SInd-SRR3963457-G1
PKB70885  298 RCIDLAPIPPANMVRLRRLY 317 SAR202 cluster bacterium Io17-Chloro-G6
PKB77898  319 AFSGKGPLSRENMVRLETVW 338 SAR202 cluster bacterium Io17-Chloro-G9
BAO92185  312 AVSGMGPFPDDLNARLERVW 331 Burkholderia sp. RPE67
OUV73888  301 AGAERGALGSAAMKKLEKLW 320 Flavobacteriales bacterium TMED123
OED40083  304 AAVNRGPLPAQALTRIKEIQ 323 Chromatiales bacterium (ex Bugula neritina AB1)
OUU48840  301 EGYNFGSLEDEILEEIYAMQ 320 Alphaproteobacteria bacterium TMED54
AUT66687  318 AAAQAGPLEPERLQQIAARF 337 Burkholderia terrae

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