Conserved Protein Domain Family
PRK09518

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PRK09518: PRK09518 
bifunctional cytidylate kinase/GTPase Der; Reviewed
Statistics
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PSSM-Id: 236546
Aligned: 14 rows
Threshold Bit Score: 1090.6
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
172040767  22 GFLLAIDGPSGTGKSTVSRRIAQYAGARYLDTGAMYRVATLHVLKAGIDPADPA-------------------ATEAIIE 82 
296454185   1 MIRVAIDGPAGVGKSSTSKALAKYFGYAYLDTGAMYRACAWWCLKQGIDLDAETvde--------------rvITEAVGE 66 
213692049   1 MIRVAIDGPAGVGKSSTSKALAKYFGYAYLDTGAMYRACAWWCLKQGIDLDAETvde--------------rvITEAVGE 66 
283456054   1 MIRVAIDGPAGVGKSSTSKALAKYYGFAYLDTGAMYRACTWWCLHKGIDLDADIvde--------------qvITETVGE 66 
28493018    4 TSIVAIDGPAGSGKSSVGRAVAQYLGYGFLPTGSYYRAFAFL-LDQTKDLDSQLdsf-------------issVRNDLDP 69 
283783291   1 MICVAIDGPAGVGKSSTSRALAQYYGFAYLDTGAMYRAAAWWCLKQGIDLSTKLeldeegnpvnpadterfnqIIEAVGA 80 
68535955   26 GLIVAVDGPSGTGKSTVCRRLATAADAKYLDTGAMYRVATLHVLRQGIDPSEES-------------------AREAIIA 86 
237785456  19 GVIVAVDGPSGTGKSTVCRTVASRLNASYLDTGAMYRVATLHVLNAGIDPED----------------------SDAVIE 76 
189439326   1 MIRVAIDGPAGVGKSSTSKALAKYFGYAYLDTGAMYRACAWWCLKQDIDLDAETvde--------------rvITEAVGE 66 
161485602   1 MIRVAIDGPAGVGKSSTSKALAKYFGYAYLDTGAMYRACAWWCLKQGIDLDAETvde--------------rvITEAVGE 66 
172040767  83 ATSQLPLQVNEDP--QSTEVLLDGEDVSADIRGPEVTAHVSAVAAIPEVRTNLVQLQRDLAAAAG---------RCVVEG 151
296454185  67 FFTGDHFDISVDP--DNPCVFADDEDISEAIRSSEVSSHVSKVSNVIPVRNVLIAAQRAYIAREAsadsfsgglGIVAEG 144
213692049  67 FFTGDHFDISVDP--DNPCVFADDEDISEAIRSSEVSSHVSKVSNVIPVRNVLIAAQRAYIAREAsadsfsgglGIVAEG 144
283456054  67 FFTEGHFDISVDP--DNPKVTADGVDISAEIRSSEVSSHVSKVSNVIPVRHVLIAAQRAYIAREAsadsfsrglGVVAEG 144
28493018   70 YNSGFNVHIDDSPffGSSGISASSRNIASELNNPEITSKTAAVARNKSVRVRLNEYFRKLCSESIy-------pAIVLEG 142
283783291  81 LFTESDADFSVDP--KNPVVTVEGEDISEELRSSEVSSHVSTVSSIPAVRRMLIAAQRAYIASESdedsfsggeGIVAEG 158
68535955   87 ATADLPLEINEDP--TSTEVLLDGTDVSGEIRGPEVTAHVSAVAAIPEVRENLVALQRSLAFAAG---------RCVVEG 155
237785456  77 ATSDLPIAINDDP--HSTEVILDGTNVADDIRTARVTRAVSSVAAIPEVRQNLVALQRSLAHKAG---------RCVVEG 145
189439326  67 FFTGDHFDISVDP--DNPRVFADDEDISEVIRSSEVSSHVSKVSNVIPVRNVLIAAQRAYIAREAsadsfsgglGIVAEG 144
161485602  67 FFTGDHFDISVDP--DNPRVFADDEDISEAIRSSEVSSHVSKVSNVIPVRNVLIAAQRAYIAREAsadsfsgglGIVAEG 144
172040767 152 RDIGTVVLPDAPVKVYMTASAEVRAQRRFDQ-----DtaagrevTFEAVLADVQRRDEADStRETSPLRPAEDATMLDTG 226
296454185 145 RDITTVVSPDAEVRVLLTAREEVRQARRTGQ-----A-------VKGVGAEDVAARDKADS-KVTSFLTAADGVTTIDNS 211
213692049 145 RDITTVVSPDAEVRVLLTAREEVRQARRTGQ-----A-------VKGVGAEDVAARDKADS-KVTSFLTAADGVTTIDNS 211
283456054 145 RDITTVVAPDAEVRILLTAREEVRQARRAGQ-----S-------ASGVGTENVAARDKADS-KVTNFTSAAEGVLTVDNS 211
28493018  143 RDATTVIAPNARVKIFLTASLVKRAARRSEQ-----Lss----ePPNSVLEALRQRDEADN-AVTDFLSDDSSRITLDTS 212
283783291 159 RDITTVVASNAQVRVLLTAREEVRQARRNKQniaqeNlqnneskNNESEEDDIHARDAKDA-KVTHFLQAADGVTTLDNS 237
68535955  156 RDIGTVVLSDAPVKIFMTASAEVRAQRRYDQ-----DleagreaDYEAVLADVQRRDEADSsRKTSPLRPAEDAVIVDTG 230
237785456 146 RDIGTVVLADAPCKVFMTAEPSIRAQRRYDQ-----DreagrdiTFDEVLRDVQERDRKDSsRTDSPLMPADDAIVVDTS 220
189439326 145 RDITTVVSPDAEVRVLLTAREEVRQARRTGQ-----A-------VKGVGAEDVAARDKADS-KVTSFLTAADGVTTIDNS 211
161485602 145 RDITTVVSPDAEVRVLLTAREEVRQARRTGQ-----A-------VKGVGAEDVAARDKADS-KVTSFLTAADGVTTIDNS 211
172040767 227 EMSIDEVIEAIAGLieesdldsaipadgae----stgglvfrtveghvvpADGDASVQEVSEedlenwdpenwdg--etw 300
296454185 212 DLDFAHTLDLLIGV------------------------------------VEDAIENQEYEQ------------------ 237
213692049 212 DLDFAHTLDLLIGL------------------------------------VEDAIENQEYEQ------------------ 237
283456054 212 DLEFSETLDVLVRI------------------------------------VDDAIEEQEYRQ------------------ 237
28493018  213 DLTFSESVARVLEV------------------------------------IEQAGMPFVSDK------------------ 238
283783291 238 DLTFEQTLDALVEM------------------------------------VDAAIEQDEYDR------------------ 263
68535955  231 EMDIDEVLEKLAQLtlasakpdsldsp----------eelvfrtadgevlGESDFSAVEFSEydddefdeg--------- 291
237785456 221 HQGIDEVVETIISLvrqsssdndradddrpdedssledlvftttegqaigDEDSVDTVDIADatdadehtdraddgdhtd 300
189439326 212 DLDFAHTLDLLIGL------------------------------------VEDAIENQEYEQ------------------ 237
161485602 212 DLDFAHTLDLLIGL------------------------------------VEDAIENQEYEQ------------------ 237
172040767 301 evdpeqlgeHYLQAENFDLLesd---eeDTDWESIEEAFGIADELEAQKEALCTVAIVGRPNVGKSTLVNRFIGRREAVV 377
296454185 238 ---------YAANLEGYELD--------EGDEDLISGRGFTEGARKAGPKPVGVLAVVGRPNVGKSSLVNRILGRRAAVV 300
213692049 238 ---------YAANLEGYELD--------EGDEDLISGRGFTEGARKAGPKPVGVLAIVGRPNVGKSSLVNRILGRRAAVV 300
283456054 238 ---------YVANLDDYELD--------EGDEGLIDGSSFVGGDLQAGPKPVGVLAVVGRPNVGKSTLVNRILGRRAAVV 300
28493018  239 ---------WV-----------------GENADVLAASG----------ELGATVVIVGRPNVGKSALVNCILGRREAVV 282
283783291 264 ---------YAANLEGYDLD--------DEDRALLRGDEVSQDDAKDS-KAVGVIAIIGRPNVGKSTLVNRILGHRVAVV 325
68535955  292 -nesspeefFITGPDDFTLEgggdmpesDEDWEALEEAFGVLGDEEAEQEALCTVAIVGRPNVGKSTLVNRFIGRREAVV 370
237785456 301 epsgdatdgDITDDEVNNLLvts---dsDTDWHSVEEAFGVFDDAGYTSEALCTVAILGRPNVGKSTLVNRFIGRREAVV 377
189439326 238 ---------YAANLEGYELD--------EGDEDLISGRGFTEGARKAGPKPVGVLAVVGRPNVGKSSLVNRILGRRAAVV 300
161485602 238 ---------YAANLEGYELD--------EGDEDLISGRGFTEGARKAGPKPVGVLAVVGRPNVGKSSLVNRILGRRAAVV 300
172040767 378 EDFPGVTRDRISYLGDWGGRRFWVQDTGGWDPDAKGIHAAIARQAETAMATADAIVFVVDTKVGITETDEVIARKLQRSD 457
296454185 301 EDTPGVTRDRVSYDAEWAGTDFKLVDTGGWEADVEGIESAIASQAQIAVTLADAVVFVVDGQVGMTTTDERIVKMLRAAG 380
213692049 301 EDTPGVTRDRVSYDAEWAGTDFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVDGQVGMTTTDERIVKMLRAAG 380
283456054 301 EDTPGVTRDRVSYDAEWAGTDFKLVDTGGWEADVEGIESAIASQAQMAVQLADAVVLVVDGQVGLTSTDERIVKMLRASG 380
28493018  283 ENRPGVTRDRVVYPAFWAGRPFTLVDTGGWECDAEGLDAEVVAQAEIGMSIADIIIFVVDVQHGPVSTDAVIARNLQRQN 362
283783291 326 EDTPGVTRDRVSYDAEWAGTNFKLVDTGGWEADVEGIDSSIAQQAQIAVRLSDAVIFLVDGQVGLTATDERIVSMLRAAG 405
68535955  371 EDFPGVTRDRISYLGEWSGRRFWVQDTGGWDPDAKGIHAAIARQAETAMETADVIVFVVDSKVGITSTDEVIARKLQRSK 450
237785456 378 EDFPGVTRDRISYLGEWNGRRFWVQDTGGWDPDAKGMHAAIARQAEGAMKTADVIVFVVDSQVGITASDEMLARKLHRAE 457
189439326 301 EDTPGVTRDRVSYDAEWAGTDFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVDGQVGMTTTDERIVKMLRAAG 380
161485602 301 EDTPGVTRDRVSYDAEWAGTDFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVDGQVGMTTTDERIVKMLRAAG 380
172040767 458 VPVIVVANKFESDTQYADMAEFWALGLDNPYPVSALHGRGAADVLDKLLEVFPETPRELSVV--SGPRRVALVGRPNVGK 535
296454185 381 KPVVLAVNKIDDQASEYLAAEFWKLGLGEPYSISAMHGRGVGDLLDVALDKLKQAEKTSGYLtpSGLRRVALVGRPNVGK 460
213692049 381 KPIVLAVNKIDDQASEYLAAEFWKLGLGEPYSISAMHGRGVGDLLDVALDKLKQAEKTSGYLtpSGLRRVALVGRPNVGK 460
283456054 381 KPVTLAVNKVDDRESEYLTAEFWKMGMGEPYGISAMHGRGIGELLDVALESLKKAKKTSGFLtpSHLRRVALVGRPNVGK 460
28493018  363 KPIFLVANKADNASSDSDVAQFWSLGLGQPYACSATHGRGVADLMDIVMQSAQVHTPSFC----SGAPRVALIGRPNVGK 438
283783291 406 KPITLAVNKVDDARSEYLTAEFWKLGMGEPYGISAMHGRGVGDLLDAALNSLKKANKTSGFLtpEGLRRVALVGRPNVGK 485
68535955  451 VPVIVVANKCDADAQLGDVAEFWALGLDNPYPVSAQHGKGAADVMDEVLRVFPEHPRELSVV--SGPRRVALVGRPNVGK 528
237785456 458 QPVVLVANKFDSPTQYGDLAEFWALGLDNPYPVSAKHGHGAADVLDEVIRLFPDKPRQESIT--SGPRRVALVGKPNVGK 535
189439326 381 KPVVLAVNKIDDQASEYLAAEFWKLGLGEPYSISAMHGRGVGDLLDVALDKLKQAEKTSGYLtpSGLRRVALVGRPNVGK 460
161485602 381 KPVVLAVNKIDDQASEYLAAEFWKLGLGEPYSISAMHGRGVGDLLDVALDKLKQAEKTSGYLtpSGLRRVALVGRPNVGK 460
172040767 536 SSLLNKISGEQRSVVDNVAGTTVDPVDSIVELEERTWRFVDTAGIRKKVKNAVGHEYYASLRTRAAIDASEVVVFLADAS 615
296454185 461 SSLLNQLAREERAVVNDLAGTTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDAS 540
213692049 461 SSLLNQLAREERAVVNDLAGTTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDAS 540
283456054 461 SSLLNQLAHEERSVVNDLAGTTRDPVDEVVTVDGEDWLFIDTAGIKRRLHKLSGAEYFSSLRTQAAIERSELALVLFDAS 540
28493018  439 SSLINQLTNSRRAIVDDLAGTTRDPLDALAVIGDKSWLFVDTAGLRRKFKSQKGADFYAYLRATTVLRRTEIALLLLDAS 518
283783291 486 SSLLNHLAHEERSVVNDLAGTTRDPVDEVVRVDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERSELALILFDSS 565
68535955  529 SSLLNKITGEERSVVNNVAGTTVDPVDSIVELEEKTWKFVDTAGIRKKTKQARGHEFYASLRTRSAIDAAEVVVFLVDAS 608
237785456 536 SSLLNKMTGEDRAVVDDVAGTTVDPVDSLVELDQKTWTFVDTAGIRKKTKKATGHEYYAGLRTRGAIDAAEVVVFIVDAS 615
189439326 461 SSLLNQLAREERAVVNDLAGTTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDAS 540
161485602 461 SSLLNQLAREERAVVNDLAGTTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDAS 540
172040767 616 EPIAEQDQRVLRMILDAGKALVVAFNKWDLVDEDRRELLEREIDLQLSHVPWARRVNISAKTGRALQKLEPAMMEALDSW 695
296454185 541 QPVSDQDLKVMSTAVDAGRAIVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSAKTGWHTNRLTRAMDKALESW 620
213692049 541 QPVSDQDLKVMSTAVDAGRAIVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSAKTGWHTNRLTRAMDKALESW 620
283456054 541 QPISDQDLKVMSQAVDAGRAIVLVFNKWDLMDEFDRQRMERLWKTEFDRVTWAQRVNLSAKTGWHTNRLANAMRGALESW 620
28493018  519 HAITEQDVRIAEMVVESGRALVIAINKWDLLDEERRYWLEREIDNTFFRFAWAPRVNISARTGRGVKQLATALQTALTNW 598
283783291 566 QPIAEQDLKVMSQAVDAGRAIVLVFNKWDLMDEFSRQRMERLWKTEFERVTWAERVNLSAKTGWHTNRLARAMRTALDSW 645
68535955  609 EPIAEQDQRVLRMILDSGRALVVAYNKWDLVDEDRRELLEREIELQLSHVPWARRVNISAKTGRALQKLEPAMIEALESW 688
237785456 616 EPVTEQDQRVLRMILDSGRALVVAYNKWDMVDEDRRDMLDREIELQLSHIPWARRVNISAKTGRAIHKLEPAMIEALESW 695
189439326 541 QPVSDQDLKVMSTAVDAGRAIVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSAKTGWHTNRLTRAMDKALESW 620
161485602 541 QPVSDQDLKVMSTAVDAGRAIVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSAKTGWHTNRLTRAMDKALESW 620
172040767 696 DQRIPTGQLNTWLRAVIAETPPPMRGGRLPRVLFATQASSRPPVIVLFTTGFLEHGYRRFLERKLRETFGFEGSPVRIAI 775
296454185 621 DQRIPTGKLNAFLGKIQAAHPHPLRGGKQPRILFATQASTRPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISV 700
213692049 621 DQRIPTGKLNAFLGKIQAAHPHPLRGGKQPRILFATQASTRPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISV 700
283456054 621 DKRIPTGKLNAFLGKIQAAHPHPLRGGKQPRILFATQASTRPPRFVIFATGFLEHGYRRYIERCLREEFGFDGSPVQISV 700
28493018  599 NTRLNTARVNHFLQRITREQPHPTRGGRRPRILFASQTGVAPPTFTLFTTGFLEPTYRRFLQKSIRSQHSFTGSPIILSV 678
283783291 646 DKRIPTGKLNAFLGRIQSAHPHPLRGGKQARILFATQASTRPPRFVIFTTGFLEHGYRRFIERSLREEFGFEGTPIQISV 725
68535955  689 DQRISTGQLNTWLRAVIAETPPPMRGGRLPRVLFATQASTKPPVIVLFTTGFLEHGYRRFLERKLRESFGFEGSPVRIAV 768
237785456 696 DGRVPTGQLNTWLRAVIAETPPPMRGGRLPRVLFATQASTRPPVIVLFTTGFLEHGYRRFLERKFRETFGFTGSPVRIAV 775
189439326 621 DQRIPTGKLNAFLGKIQAAHPHPLRGGKQPRILFATQASTRPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISV 700
161485602 621 DQRIPTGKLNAFLGKIQAAHPHPLRGGKQPRILFATQASTRPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISV 700
172040767 776 RIREKKKKR 784
296454185 701 NIREKKKRK 709
213692049 701 NIREKKKRK 709
283456054 701 NIREKKKRK 709
28493018  679 KIRASRNR- 686
283783291 726 KVRDKKKRK 734
68535955  769 RVREKKRKK 777
237785456 776 RVREKRGRK 784
189439326 701 NIREKKKRK 709
161485602 701 NIREKKKRK 709
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