Conserved Protein Domain Family
kgd
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PRK12270: kgd 
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
Links
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Statistics
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PSSM-Id: 237030
Aligned: 93 rows
Threshold Bit Score: 1640.76
Created: 9-Dec-2010
Updated: 17-Jun-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
268317917    1 MSTLGFNTGYVEELYRQYLENPESVSESWREFFADYRPGESFVAARET-------------------------------- 48  
50842739    13 SPDFGANDWLIEEMRDQYQSDPNSVDPAWATFFRKEAVESTDSVTKSAakdvpgasa----------------------- 69  
295130820   13 SPDFGANDWLIEEMRDQYQSDPNSVDPAWATFFRKEAVESTDSVTKSAakdvpgasa----------------------- 69  
297626222    3 TDKFGANDWLIADMRQRYLADPTSVDERWRAYFQALGVTPDPSTPVASpapvtpaptqap-------------------- 62  
256372497   15 SEQFGPNDWFVEEMAERYRANPLLVPESWRAYFEGERVPDGVATKTIAtatakelvgfeapgv----------------- 77  
256825652   10 QATFGANDWLVEDKYEQFQQDPSSVGPEWQELFATWSPEGGQAPSDAGaapsagkaprdskpaeeakqkapakdaekqkd 89  
193216266   13 VWRFGSNASYISDLYERYVNEPNQLRADWRQFFDGLLSGKLDLNSPESewhl---------------------------- 64  
83815605     1 MSSLGFNTGYIEELYKQYQDDPDSVSESWREFFADYDPDASFIPVDRTtagdgeat------------------------ 56  
294507171    1 MSSLGFNTGYIEELYKQYQDDPDSVSESWREFFADYDPDASFIPVDRTtagdgeat------------------------ 56  
116624386    6 GSEMGVNSWLEDELYQQYLHDRSAVDESWKQVFAEPRPGNGVKAAAPA-------------------------------- 53  

268317917   49 --------------------------TQAPAEVPAAVGRPGGDGAAPEEAVSELAPEEVEEH------------------ 84  
50842739    70 -----------------pkpatkpqpVPAAKPAPITAPKPQKQPPRPPMSADAPRHSAKLETvep--------------- 117 
295130820   70 -----------------pkpatkpqpVPAAKPAPITAPKPQKQPPRPPMSADAPRHSAKLETvep--------------- 117 
297626222   63 --------------tpqaptpqaptsSAPGPNEPAQPPSSRVQAPVPTLEPREIRRNAPEQPgmggglsadvpnpa---- 124 
256372497   78 ------------atppttatpaptspPHNGATPQTAPFTPASSPEAVDPLTPPRSSAPETAPhasepavst--------- 136 
256825652   90 agkqadtgkqkdtaagrtedkaeqhqSPTSQDGKDAQKSSASKSSGSTEKVSPSQKRSVVNTeaetlgeelnpprrrpls 169 
193216266   65 -----------------------paqKSDDRDFWDTGIKEVKSVVGGEPSFVRKDEQFVLAPnde--------------- 106 
83815605    57 ------------------tppeeptePEPTDRDSSPDASSAPPAEADDGVVEPLRPASAPAVdedq-------------- 104 
294507171   57 ------------------tppeeptePEPTDRDSSPDASPAPPAEADDGVVEPLRPASAPAVdedq-------------- 104 
116624386   54 ----------------------------IPALAPSVTPAege-------------------------------------- 67  

268317917   85 ------------------PLRGPAARIVENMEASLKVPTATSVRTISVRLLAENRALINDYQRHVGGEKVSFTHLIAWAV 146 
50842739   118 ---------------tvtKMKGAPMRTAKNMDQSLTMPTATTVRDVPMQLVIEQRTMINSFLKKAKGGKVSFTHILAYAM 182 
295130820  118 ---------------tvtKMKGAPMRTAKNMDQSLTMPTATTVRNVPMQLVIEQRTMINSFLKKAKGGKVSFTHILAYAM 182 
297626222  125 ----vrpakkaegqatrtVLRGIPKTTAVNMNESLSVPTATSVRQVPMKLVIDNRALVNSFMARTRGGKVSFTHIIAFAM 200 
256372497  137 ----------tptvpsaqPLRGAQGALARNMEASLAVPTATSVRAVPTRALEVNRATINDQLQRLGRSKVSFGHLVAWAI 206 
256825652  170 rdmpsprdvqgeaepsteKIKGTAGAIVKAMDASLTVPTATSVRAVPAKALIDNRIVINGHLARNRGGKISFTHLIGYAL 249 
193216266  107 ----------------aiLLHSLQAKIVENMEDSLEIPTATSMRKVPVVVLDENRRIINQHLSATGDGKAGFTHLLAWAL 170 
83815605   105 --------------advtAMTGPSAKVVENMEDSLGIPTATSARTIPVKLLDENRNLLNDYQKQVGGEKVSYTHIIAYAM 170 
294507171  105 --------------advtAMTGPSAKVVENMEDSLGIPTATSARTIPVKLLDENRNLLNDYQKQVGGEKVSYTHIIAYAM 170 
116624386   68 ---------------qlqPLRGIAGKIAENMGASLSIPLATSQRTIAVKVMDENRRIINQHRTLVGQGKVSYTHLIGWAV 132 

268317917  147 VQALKAFPNMNSTFRR-DDGT--PIHVQPKTINLGIAIDLERR-GKRMLLVPNIKHADRMNFAQFLGAYNDIVARARDGR 222 
50842739   183 VQALKTVPAMNNAYAE-IDGK--PHLIENHQINLGMAIDVIASdGSRKLVVPAIKGAEQMDFLDFWRAYEEIVRKGRTNE 259 
295130820  183 VQALKTVPAMNNAYAE-IDGK--PHLIENHQINLGMAIDVVASdGSRKLVVPAIKGAEQMDFLDFWRAYEEIVRKGRTNE 259 
297626222  201 VQAIRDVPEMNHSFDM-TDGK--PTLVENPAINLGIAIDTTAKnGTRELLVPNIKDAGNLDFAQFWSAYEDLVDRTRSGK 277 
256372497  207 VRALVEHPRMHASYVAdADGRghPGIVIPESVNLGIAVDVQRPdGTRSLLVPVIRNADTLGPLGFFAAYDDAVRAVRSQQ 286 
256825652  250 VKAVRAMPDMNFVYGTdEKDK--PQVTNPGTLNLGIAIDMKKPdGSRTLLVPSIKHADQMDFTQFWYAYDALVAKARDNK 327 
193216266  171 VKALQKYPSLNAFFAR-INGK--PHKVLRGDINVGIAIDLTRKdGSRMLVVPNIKRAQAMNFKQFYDAYNHILNKARQNK 247 
83815605   171 VQAMQKYPDMNTTFRRnEDGT--PEHVKPDQINLGLAIDVERR-GERTLLVPNLKDAGSLSFAEFLGTYNNIVGRALGGD 247 
294507171  171 VQAMQKYPDMNTTFRRnEDGT--PEHVKPDQINLGLAIDVERR-GERTLLVPNLKDAGSLSFAEFLGTYNNIVGRALDGD 247 
116624386  133 VKALEEIPGINHAYTE-RDGQ--PFRVMHPEINLGIAVDVAGKdGGRTLMVPNIKNAGGLSFQEYVTAFDDLVSRARKGK 209 

268317917  223 LDVSDFQGTTATITNPGMIGTVMSVPRLMAGQGVIVGVGAIGYPPEYAALPSDMLSRLGLSQVMTITSTYDHRVIQGAES 302 
50842739   260 LTVDDFKGVTASLTNPGGFGTNHSIARLMPGQGMILGVGSIDYPAAYQGNSPTRIAELGISKVTTLTSTYDHRIIQGAQS 339 
295130820  260 LTVDDFKGVTASLTNPGGFGTNHSIARLMPGQGMILGVGSIDYPAAYQGNSPTRIAELGISKVTTLTSTYDHRIIQGAQS 339 
297626222  278 LTLEDYAGTTVSITNPGGIGTNMSVPRLMSGQAMIMGVGSIDYPAAFQGTSTQRTNDAAISKVCTLTSTYDHRIIQGAVS 357 
256372497  287 ASPDLFVGATASITNPGTIGTEHSIPRLMPGQGVIVGVGAIAYPAAFQAADPRLLGELGVSRTITLTSTYDHRIIQGAES 366 
256825652  328 LDIADLSGTTMSLTNPGGIGTTHSVPRLMSGQAAIIGVGALEYPAEFQGMSPERIAEDAVSKILTLTSTYDHRVIQGAAS 407 
193216266  248 LDLSDFQNTSVSLTNPGTLGTLMSVARLTKGQGFILAAGAIEYRTEFQAMPKELLFQLGISKVMNLSNTYDHRIIQGAES 327 
83815605   248 LDLSDFQGTTATLTNPGMIGTSMSVARLMPGQGVIMGAGAIDFPPEYRGYDSEVASKAGVSPVMTLTSTYDHRVIQGATS 327 
294507171  248 LDLSDFQGTTATLTNPGMIGTSMSVARLMPGQGVIMGAGAIDFPPEYRGYDSEVASKAGVSPVMTLTSTYDHRVIQGATS 327 
116624386  210 LLPADFQGTTISLTNPGTVGTMASIPRLMPGQGAIIATGAIDYPAEYQGAADETRAMLGISKVMTLTCAYDHRIIQGAES 289 

268317917  303 GAFLAYIDELLQGQHEFYERVFADLGIPYQPYRLAKDTtpllggleNGEELTMIQKQAAVLQLIRAYRVRGHLQADINPL 382 
50842739   340 GEFLRRMHQLLLGADRFYEDIFESLRIPYAPVQWASDR--------LANRADQVGKQARVIELIDAWRRFGHLSADLDPI 411 
295130820  340 GEFLRRMHQLLLGADRFYEDIFESLRIPYAPVQWASDR--------LANRADQVGKQARVIELIDAWRRFGHLSADLDPI 411 
297626222  358 GEFLRRIHQLLLGADGFYEHIYEALRIPYPPLHWDRDF--------TANSQSEISKGARVTELIQAYRAEGHLLADLDPV 429 
256372497  367 GQFLATIAALLEGEQDFYDEIFSALQVPYPPMRWQADHts-----mQPDATERLAKQVHVQSLIHHYRVRGHLLATLDPL 441 
256825652  408 GEFLKLVHGYLNGEDGFYDEIFQSLRIPYEPVRWTPDI--------AAVHENDLSKDARVQALIQAYRERGHLMADTDPL 479 
193216266  328 GELLAYLTKILMGEESFYEEVFSDLSMPYKPWAYKTDTnai--aysGMNTEELIIKQAKIMQMINSYRVRGHLISNVNPL 405 
83815605   328 GAFLNHIEELLTGNHDFYQRIFSDLGVPYQPFRMATDStpqlgrsrPQDELDMTEKQAAVLQLIRAYRVRGHLQADINPL 407 
294507171  328 GAFLNHIEELLTGNHDFYQRIFSDLGVPYQPFRMATDStpqlgrsrPQDELDMTEKQAAVLQLIRAYRVRGHLQADINPL 407 
116624386  290 GAFLGRLQSLLDGKDGFYEEVFNHLRMPHMPVRWETDRkptl-pgvSAARYAEIAKEAGIIQMINAYRVRGHLIADLDPL 368 

268317917  383 GY---EWKYHPELDPATYGLTIWDLDRQFVTGGLG---GK--DV--APLREILDILRQTYTRKIGIEYMHISDPTERRWL 452 
50842739   412 EY---RPRFHRDLMLNSHGLTLWDFDRTFPIANFA---GQ--RRatMSLREILTILRDSYASKMGIEYMHIADYEQRKWF 483 
295130820  412 EY---RPRFHRDLMLNSHGLTLWDFDRTFPIANFA---GQ--RRatMSLREILTILRDSYASKMGIEYMHIADYEQRKWF 483 
297626222  430 EY---RMRTHPDLDLATHGLSIWDLDREFPVGRFG---GEegRH--IVLRQMLDILRESYCYTLAIEYMHIDDPEERAWV 501 
256372497  442 DLtrpTMS--PELDPATYGLTLWDLSRPFLAEGLVp-gGQ------ASLETILQVLRDTYCQTIGYEFMHIQSPDEKLWI 512 
256825652  480 EY---QLRRHPDLDINTHGLTLWDLDREFPTNGFG---GA--DR--LPLRDILGILRDSYCRTIGVEYMYISDPVQRRWM 549 
193216266  406 GYda---dFHPELDPEFYDLTIWDLNREFVTVGFG---GK--PK--HQLREIIDILRQAYCGKIGIEYMNIQSLEQKKWI 475 
83815605   408 GY---EWQYHEELDPATYGLTVWDLDREFITGGLG---GE--DK--LPLREILSILRKSYTSKVGTAFMHISDPEEKTWI 477 
294507171  408 GY---EWQYHEELDPATYGLTVWDLDREFITGGLG---GE--DK--LPLREILSILRKSYTSKVGTAFMHISDPEEKTWI 477 
116624386  369 GS---EPSLHAELDPETYGLTIWDLDREFLTGSLGeaiGEgaPKslATLREILETLRQTYCGKIGCEYMNIQVPEQKRWL 445 

268317917  453 QERIEpvRAADPISPDMRRRILQKLNAAEAFERFLHTKYIGHKRFSLEGAESLIPILDTILSDAADQEVEEVVIGMAHRG 532 
50842739   484 QDRFE--KEHQPLSRKMHLQILDQLNEAEIFETFLQTKFVGQKRFSLEGGESAIVLLAALCNRAADDGLNEVCIGMPHRG 561 
295130820  484 QDRFE--KEHQPLSRKMHLQILDQLNEAEIFETFLQTKFVGQKRFSLEGGESAIVLLAALCNRAADDGLNEVCIGMPHRG 561 
297626222  502 QERFE--RPRKPRPREEHLLILDRLSEAEVFETFLQTKYVGQTRFSMEGAESSIVILSELCAAAADGGMAEVSIGMPHRG 579 
256372497  513 QQRIE--GSHQTLTKDDQLRILATLNDAEAFEKFLSTRYIGQKRFGLEGGESAIVFLREVLDHAAETGTHAAVIGMAHRG 590 
256825652  550 QEQLE--QPFEKPGREEQLNLLGRLNAAEAFETFLQTKFVGQKRFSLEGGESVIAMLDTILRGAAADGLDEVCIGMPHRG 627 
193216266  476 QSRVEpkENQLSYSPNSRKRILKNLIRAESFETYLHSKFLGHKRFSIEGAESAIAILDFLIEYAGRCFTEEVVIGMAHRG 555 
83815605   478 QNRIEpmRNAGSPSEEERHRIVQKLNAAEAFERFLHTKYIGHKRFSLEGSETMIPLIDTLLSDAADEGVEEVVMGMAHRG 557 
294507171  478 QNRIEpmRNAGSPSEEERHRIVQKLNAAEAFERFLHTKYIGHKRFSLEGSETMIPLIDTLLSDAADEGVEEVVMGMAHRG 557 
116624386  446 QQRMEpeANNWLLDRETRLRTLHSVIAGEEFEHFLHSRFVGQKRFALEGGETALAILEEILERAAGRNVHEIVVGMAHRG 525 

268317917  533 RLNVLANILGKPYEVIFSEFEGnIDP----NTTQGSGDVKYHLGAKGVHRSPSGNEVKITLASNPSHLEAVDPVVEGMVR 608 
50842739   562 RLNVLANIIGKSYGQIFREFEGnAEP----VNSQGSGDVKYHLGDEGQFTAASGNTIKASVAANPSHLEAVDPVLEGICR 637 
295130820  562 RLNVLANIIGKSYGQIFREFEGnAEP----VNSQGSGDVKYHLGDEGQFTAASGNTIKASVAANPSHLEAVDPVLEGICR 637 
297626222  580 RLNVLTNVVGKLYSQVFREFDNkV-P----TEEDITGDVKYHLGATGQFTAMSGEKIKVSLAANPSHLEAVDPVLEGIAR 654 
256372497  591 RLNVLANIVGKSYRTIFAEFEGnLDP----SSVQGSGDVKYHKGFEGHYRTASGSELPVTLASNPSHLEAVDPVVEGMVR 666 
256825652  628 RLNVLANIAGKSYAQIFREFEG--ES----GATSGSGDVKYHLGTSGTFTDDEGNEVGVYLAANPSHLEAVNPVLEGIAR 701 
193216266  556 RINVLANIIGKPYYKLFAEFIDkHLPlppdDLIHGSGDVKYHLGASGVRKTVDGREVKVWLASNPSHLEAVNPVVEGVAR 635 
83815605   558 RLNVLANIIGKPYEEIFSKFEGnIDP----NTTQGSGDVKYHLGAEGDVTSPDGNEISVTLASNPSHLEAVNPVVEGMSR 633 
294507171  558 RLNVLANIIGKPYEEIFSKFEGnIDP----NTTQGSGDVKYHLGAEGDVTSPDGNEISVTLASNPSHLEAVNPVVEGMSR 633 
116624386  526 RLNILANTVGKDVKQIFSEFEGeIDP----GSTQGSGDVKYHLGATGMRRTSNGREIVVSVSPNPSHLEAVDPVVEGIVR 601 

268317917  609 AKQDQLRrQraEApGGdyyDAVIPILIHGDAAFAGQGVVAETLNLSQLRGYKTGGTIHIVVNNQIGFTTAPADARSSTYA 688 
50842739   638 AKLDALG--------NpegFPVLPILMHGDAAFAGQGVVYETLQMSQLGGYRTGGTIHVIVNNQVGFTTSPRDGRSSTYC 709 
295130820  638 AKLDALG--------NpegFPVLPILMHGDAAFAGQGVVYETLQMSQLGGYRTGGTIHVIVNNQVGFTTSPRDGRSSTYC 709 
297626222  655 AKRDRQPvP--AD------YPVLPILMHGDASFSAQGIVYEVLQMSQLRPYRVGGTVHLVVNNQLGFTTSPSDGRSSKYC 726 
256372497  667 ALQDQRGtL--YE------FGVLGILVHGDASFAGQGVVAETLNLSQLPGYRTGGTVHLVINNQVGFTTNPSEARSSFYA 738 
256825652  702 AKQDRLAtN--GE------YPVLPILMHGDAAFAGQGVVAETLQMSRLSGYKTGGTIHIVVNNQVGFTTSPLEGRTSRYS 773 
193216266  636 AKQDRAGdK--EG------KKVMPLLLHGDAAFAGQGVVAETLNLSQLTGYCTNGTIHLIINNQIGFTTTPAEARSSRYA 707 
83815605   634 AKQNLLRdEhpEAaEDdyhDAVMPLLIHGDAGFAGQGVVAETLNLSKLRGYTTGGTVHLVINNQIGFTTPPGDARSSTYA 713 
294507171  634 AKQNLLRdEhpEAaEDdyhDAVMPLLIHGDAGFAGQGVVAETLNLSKLRGYTTGGTVHLVINNQIGFTTPPGDARSSTYA 713 
116624386  602 PKQDRLGdT--ER------ERVIPVLIHGDAAFAGQGVVTETLNLSQLEGYSTGGTIHLIINNQIGFTTLPDESRSTPYS 673 

268317917  689 TDIARMIQAPIFHVNGDDPEACVRVARLALDYRQVFNKDVVIDLVCYRVHGHNEADEPTYTQPLLYKKIAQKRSVRKLYT 768 
50842739   710 TDVAKAVGAPVLHVNGDDPASVVHAARIAYEYRQTFHRDVVVDVVCYRRRGHNEGDDPSFTQPHMYGLIAEKRSTRKLYT 789 
295130820  710 TDVAKAVGAPVLHVNGDDPASVVHAARIAYEYRQTFHRDVVVDVVCYRRRGHNEGDDPSFTQPHMYGLIAEKRSTRKLYT 789 
297626222  727 TDVAKALGAPVIHVNGDDPDACARAAELAFDFRARFHKDVVIDMVCYRLRGHNEGDDPSFTQPQMYDLVARKGSVRKIYT 806 
256372497  739 SDIAKTIQAPIFHVNGDDPEAVARCARLAVEYRATFHKDVVVDLICYRRHGHNEGDEPSYTQPVMYHVIEQHPSVRRLYA 818 
256825652  774 TDVAKMIEAPVFHVNGDDPEACARVAEVAFAYREAFHKDVVIDLVCYRRRGHNEGDDPSMTQPQMYTMVNNKRSVRKIYQ 853 
193216266  708 TDVAKMVQAPVFHVNGDDPEACIRVARMALDYRLRFGRDVVIDMICYRRHGHNEGDDPAYTQPVLYKKIKEKKPVNELYA 787 
83815605   714 TDLARAIEAPIFHVNGDDPETCVRIARLAFEYRQRFNKDVVIDMMCYRVHGHNEGDEPTFTQPLLYEKIEEKRSPRKLYT 793 
294507171  714 TDLARAIEAPIFHVNGDDPETCVRIARLAFEYRQRFNKDVVIDMMCYRVHGHNEGDEPTFTQPLLYEKIEEKRSPRKLYT 793 
116624386  674 TDVARGVQAPIFHVNGDDPEAAIRVVQIAFDYRQQFKTDVVIDMICYRRHGHNEGDDPSYTQPILYRKIKEHPSVATLYG 753 

268317917  769 EMLLRRGDMTPEEAERMLDDYQARLQEAFERTKNLKERDprev---veqLRKKAEDDAPLPEVETAARREDLEAVVQALV 845 
50842739   790 ESLIGRGDITTEDAEAVMTKFRSRLETVFKEVREATSTPepy----sgvPDYPVKHSGLH---QTKVEPDTMEAVARAHE 862 
295130820  790 ESLIGRGDITTEDAEAVMTKFRSRLETVFKEVREATSTPepy----sgvPDYPVKHSGLH---QTKVEPDTMEAVARAHE 862 
297626222  807 DALIGRGDISVEDAEQAVNRFRARLEEVFSMVRNPEiprdevdhqvayrLAPQYPAKERAASAPPTPTREQFERVADVYE 886 
256372497  819 DQLVRSGAISEDEADQALEAYLQRLATALAETREAAPPKpte-------lppEPARDVPLPIVTTAVDKAALDYVIETIH 891 
256825652  854 DSLLGRGDIDEDDAKAMLKDYQQKLESVFTETKQALKEAaeedk-gqgeAGAEPVAHGWDSPTDTSLSAEDLDKLGSVWA 932 
193216266  788 ERLLKEGIISEAELAQMYGEIKAELDKAYEEAKQTSEKFedk----adpIVLPELLLPITKSPETQVPLETLQFISRKLM 863 
83815605   794 EMLLRRGEIEPDEAEQMLDDYRGRLQEAFERTKDLEEKDade----aleERVQRTADDRLPPVDTTAEREHLERVVEVLT 869 
294507171  794 EMLLRRGEIEPDEAEQMLDDYRGRLQEAFERTKDLEEKDaee----aleERVQRTADDRLPRVDTTAEREHLERVVEVLT 869 
116624386  754 RRLVREGVLSVEEVQGMQKEVAARLSTAYDAVQERAERFel------qeLSAVQGEEIGGYCPRTSVNQQVLERVIRAIT 827 

268317917  846 NLPDGFHVHPKLERQFKRRESLFFk---EKKIDWAFAEALAFGTLLLEGSPVRLSGQDSRRGTFSQRHAVLYDQETGEEY 922 
50842739   863 NLPESFNAHPKVAPQMTRRAKHIR----EGGIDWATGEMIALGSLLRDGVHVRLAGQDSRRGTFSQRFAALVDHETGEFY 938 
295130820  863 NLPESFNAHPKVAPQMTRRAKHIR----EGGIDWATGEMIALGSLLRDGVHVRLAGQDSRRGTFSQRFAALVDHETGEFY 938 
297626222  887 NLPEGFTPHPKVGPQLKRRADSIH----NGPVDWATAELLAFGTLLQDRRHVRLVGQDTRRGTFSQRFGAVVDRVTNEAW 962 
256372497  892 RVPEDFHLHPKLARQFETRRALYE----QGQLDWALGELAAYGTLLLEGHDVRLSGQDTRRGTFSHRHAALYDYETGAMV 967 
256825652  933 DVPEGFTIHPKLTKLLERRKKMAA----EGGVDWGMGELLAFGATLAGGRSVRMSGQDSRRGTFTQRHAVLVDNVTADEW 1008
193216266  864 TWPENFHVNPKLVKLFEKHRTLDEekplETQVDWAFAETLAFGSLLMEGTNVRLSGQDSTRGTFSQRHLALFDTETGDEF 943 
83815605   870 DFPDDFNVHRKLERLFGKRDDLFYd---EKRIDWAFSETLAFGSLLQEGTRVRLSGQDSRRATFSQRHAVLIDQETGAEY 946 
294507171  870 DFPDDFNVHRKLERLFGKRDDLFYd---EKRIDWAFSETLAFGSLLQEGTRVRLSGQDSRRATFSQRHAVLIDQETGAEY 946 
116624386  828 QFPESFHLHPKLRGFVEKRRDVVAk---GGNLDWAFGEALAFGTLALEGTPVRLSGQDSGRGTFSQRHLVFYDSETGKRY 904 

268317917  923 IPLNHI---REGQ------AELLIYDSLLSEYAVCGFEYGYSVASPETLVLWEAQFGDFANGAQIVFDQFISAAEEKWGQ 993 
50842739   939 VPVNHL---GGEQ------AHLDVFDSPLNEYAAMGFEYGYSVARPDSLVLWEAQFGDFTNGAQTIIDEFIASAGSKWGQ 1009
295130820  939 VPVNHL---GGEQ------AHLDVFDSPLNEYAAMGFEYGYSVARPDSLVLWEAQFGDFTNGAQTIIDEFIASAGSKWGQ 1009
297626222  963 VPLKHL---SDDQ------APFDIYDSNLTEYAGMGFEYGYSTAAPDALVLWEAQYGDFANGAQTIADEFISSGFAKWQQ 1033
256372497  968 QPLARLrddEVPVphaspiGRFMVYDSSLSEYAAMGFEYGYSLVQRSALVIWEAQFGDFANGAQIVIDQFIAGALDKWDQ 1047
256825652 1009 TPLRHI---ADDQ------GRFDIYDSLLSEYAVLGFEYGYAVEDTEGLVVWEAQFGDFVDGAQTIIDEFIASSEQKWNQ 1079
193216266  944 MPLSQL---DEAQ------GKLYAFDSMLSEAAVLGFEYGYSLAEPGALVIWEAQFGDFANGAQIIIDQFISSSESKWGQ 1014
83815605   947 TPLNNL---TDDQ------ERLLIYDSLLSEYAVAGFEYGYSVVDKNALTCWEAQFGDFANGAEIVWDQFVSAAEEKWGQ 1017
294507171  947 TPLNNL---TDDQ------ERLLIYDSLLSEYAVAGFEYGYSVVDKNALTCWEAQFGDFANGAEIVWDQFVSAAEEKWGQ 1017
116624386  905 VPMQHI---SPDQ------GKFDVLDSSLSEYAVLGFEFGYSVADPLSLVIWEAQFGDFANGAQIMIDQFISCCEQKWGQ 975 

268317917  994 QSGLVCLLPHGYEGQGPEHSSARLERFLQLCAQQNMIVGNLTTPANYFHVLRRQARM-----PVKKPLVLMTPKSLLRHP 1068
50842739  1010 KSGVVLLLPHGYEGQGPDHSSARLERFLNLCSEDALAVCQPSTPASYSHLLRQHAYV-----NMHRPVVIATPKSMLRNK 1084
295130820 1010 KSGVVLLLPHGYEGQGPDHSSARLERFLNLCSEDALAVCQPSTPASYSHLLRQHAYV-----NMHRPVVIATPKSMLRNK 1084
297626222 1034 RSGVVLLLPHGYEGAGPDHSSCRIERWLQTADEGNIAVTMPSTAASYFHLLRQHAYV-----NWHRPLVVATPKSMLRNK 1108
256372497 1048 HSGLVLYLPHGYEGQGPEHSSARLERFLALAAGPNLAVVQPSTAAQLFHLVRAQVAR-----TPQRPLVVLTPKSLLRAR 1122
256825652 1080 RSRVVLLLPHGYEGQGPDHSSARIERFLTLFAEQNMTVAYPSTPANHFHLLRKQAES-----EPGRPLVVFTPKQLLRLK 1154
193216266 1015 RSGIVMLLPHGYEGQGPEHSSARIERFLQLCAGANIQVCNCTTPAQYFHLLRRQANS-----GNIKPLVVMSPKSLLRNP 1089
83815605  1018 TSGLVALLPHAYEGQGPEHSSARLERFLQLCAEQNMIVANFSTPANYFHALRRQVKR-----DVKKPLIIMTPKSLLRHP 1092
294507171 1018 TSGLVALLPHAYEGQGPEHSSARLERFLQLCAEQNMIVANFSTPANYFHALRRQVKR-----DVKKPLIIMTPKSLLRHP 1092
116624386  976 PSGLVMLLPHGYEGQGPEHSSARIERYLTLCAENNMQVCNCTTPAQYFHLLRRQMYGgsdrrGMRKPLVIFTPKSLLRHQ 1055

268317917 1069 LAVSTPEELWSGRFREVYPAETDPAE------TRRLIFCSGKIYYDLLEVllQDE---NLRRQIGLVRVEQFYPFPKAAI 1139
50842739  1085 MATSDPEDFTTGRWRPVLPDPSITDPt----aVTRIILCSGKARWELVKQ--RKAtslDGQ--LAIIPMERLYPLPVDEL 1156
295130820 1085 MATSDPEDFTTGRWRPVLPDPSITDPt----aVTRIILCSGKARWELVKQ--RKAaslDGQ--LAIIPMERLYPLPVDEL 1156
297626222 1109 AAASPLSDLLDEPWRPALADPTITDPg----aVRRVLLCAGKIRWDLVAE--RRKlglDGQ--IAIVSLERLFPLPTAEL 1180
256372497 1123 ETRSAIAAFTDGGFQPVLADPLVDDGeleptsVRRLILASGKVAYEAMAK--RAKgelAAP--TAIVRVDQLYPWPREAL 1198
256825652 1155 AAVSPIEEFTDGQFQPVIADPTSPEAn----tVKRVLVCSSRVYYDLAAE--REK---RGADDVAIIRVEQLAPIPGKEL 1225
193216266 1090 MAISKVSELAEGRFHNMLDDEQAISN------PKKVVICSGKIYYDLLKA--RAD---KQLSNVAILRLEQIYPFPEKRL 1158
83815605  1093 KCVSTPEDLMEGGVQEIIPAEADPAG------TMRHILCSGKVYYDLVTAl-EDT---DRRDEIAITRLEQFYPFPESDL 1162
294507171 1093 KCVSTPEDLMEGGVQEIIPAEADPAG------TTRHILCSGKVYYDLVTAl-EDS---DRRDEIAITRLEQFYPFPASDL 1162
116624386 1056 KAVSTLHDFTTGGFTEILSGAGVADNg----lVSRVVFCSGKIYYDLLAA--REE---RKADHVAIIRVEQLYPFAADQA 1126

268317917 1140 QAELERYRNVtDVVWVQEEPANMGAWFYMQPRLNAMLealhgdcNRRVRYVGRPASASPATGSAKVHQVEQETVVREALT 1219
50842739  1157 AEVLAPYTNVtDVRWVQEEPENQGAWYYMLTHLPQAMseklpgfFDGLVGITRPPSSAPSVGQHSVHIREEQELLEKAMA 1236
295130820 1157 AEVLAPYTNVtDVRWVQEEPENQGAWYYMLTHLPQAMseklpgfFDGLVGITRPPSSAPSVGQHSVHIREEQELLEKAMA 1236
297626222 1181 AEILRAFPQVnDFRYVQEEPENQGAWEFMDRFLTPALsea-lnrPFRMRPVTRPRSSAPSVGSHTVHLAQQRSLLAESLG 1259
256372497 1199 AAALATFPNLaELVWLQEEPENMGAWPSVHELLHRMDl-----nGARLRHVSRVRAGSPATGSAAMHALEQADLLRRALE 1273
256825652 1226 VEALGAYPDA-ELVWVQDEPRNQGAWPFMAMNLPEVFaeh--geERSLRVVSRPAAASPATGVNSTHKDEQGDLIRRAFE 1302
193216266 1159 TKLLQKYASAtEICWAQEEPKNMGAWSFVSPLLREHLk-----nEQVLRYVGRSENSSPSTGFLDLHQDEQNRIAWEAVG 1233
83815605  1163 QEELERYAEAdETVWVQEEPQNMGAWSFVSPRFETLLdeihgpcEQRIQYVGRPASASPATGSAKVHDREQEQLVGDALG 1242
294507171 1163 QEELERYSEAdETVWVQEEPQNMGAWSFVSPRFETLLdeihgpcEQRIQYVGRPASASPATGSAKVHDREQEQLVGDALG 1242
116624386 1127 RDILARYAPTaEVVWAQEEPRNMGAWRFIRECLQAVLdd----sRREIRYVGRPESASPATGSGKRHQQEQAEIVNDALT 1202

268317917 1220 L 1220
50842739       -     
295130820      -     
297626222 1260 Q 1260
256372497 1274 A 1274
256825652 1303 A 1303
193216266      -     
83815605  1243 L 1243
294507171 1243 L 1243
116624386 1203 P 1203
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