Conserved Protein Domain Family
DUF4862

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pfam16154: DUF4862 
Domain of unknown function (DUF4862)
This family consists of uncharacterized proteins around 300 residues in length and is mainly found in various high GC Gram+ bacteria, but also in several pathogenic and non-pathogenic enterobacteria (Salmonella, E. coli). Distant homology analysis suggests this could be a branch of Xylose isomerase-like TIM barrel family, but this prediction is currently not confirmed by experiment
Statistics
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PSSM-Id: 435174
Aligned: 13 rows
Threshold Bit Score: 340.107
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q3ID17             4 IVGAYASVPSdaswDQEAEHLFYQQLKNNTLIDGLEVPFTGKLHK-----YDNDWFYNQLDKNWCY-VITCIPGTMGELA 77  Pseudoalter...
WP_015884246      10 VVGAYALFAGr---PPEELPAAYRALEGLTTAGALEMPLAEVCGEtpgfdVGPDGLPTLVPAGWGV-VVTCIPAVMGRLA 85  Beutenbergi...
jgi:Sked_06690    30 lLGAYALAPS----GSPVETEVLAALPALG-VQVLEVPLPAPGTAa----ETARWVATHLPDDVDL-VVTAIPRTMQRLA 99 
WP_012085493      23 LVAGYMLAPT----DPAGEDALFAGLADLD-LAGLEYALPPEGTRs----LEPGWVERNVRPEWDL-LVTLVPTMVPRLG 92  Kineococcus...
jgi:Celf_3350      7 yVSAYITAPT----EPAAEDAFFDAVGELD-LAGLEFALQPEGHRt----LDPAWIDAHVPADSDL-VVTLVPAMTVRRA 76 
WP_013170952       6 IVGAYASLPA----SRSEQEDFYGALAAQPWVNGLEIPFRARISD------DVEWFASQLSEHFSTnMLTPIPGVMHKLG 75  Arcanobacte...
cebbi:ckrop_1874  23 IVGAYASLPF----DRRDQETYYSLLAEQAWINGLEIPFPGDLTE------SLPWLSGQIADHWDAnTITAIPGTMVNVG 92 
Q6NJR2             7 VIGAYAALPA----TRADQETFYDRLHADLEATGLELPFRDSIHD------DPAWLASQLAGRFTDsIITAIPGTMMRVW 76  Corynebacte...
WP_014401484      11 VVGAYAAVPS----ARDEQEQFYAGLADRGIASALEIPFREDLFD------PIEWQAEHFTHRFEDsVLTLIPGTMQRLG 80  Corynebacte...
WP_014845597       5 IVGAHAAMPF----EREDQESFYAGLAERNLATALEIPVSDSIHE------DPAWFVSQVRGRFRRgVVTALPGTVKRLA 74  Arachnia pr...
WP_012135716       9 IIGAYPCAPSfhqkSEEEEKEFWRQLSDTPDIRGLEQPCLEHLHP-----LGDAWLLRHTPGNWQI-VVTAIMETMRRRG 82  Citrobacter...
CBL55737          31 VVGAYLSQPL----EQVKRPAYAHAVLQLPGVTGLEIPLCTTMAR-----DDAKWLMDVLPPGARN-IATLMGACDEAAA 100
Q21DP8             4 FVGAYATSPSamgwDAAVESEYYNQLKGYSNIKGLEHPFVGKLHG-----EDDEWFLQNISSDWEF-VFTCVPGTMAAIG 77  Saccharopha...
Q3ID17            78 KDPHFGIASDNEAGRLNALAFYQQANAEIAKLNNHFNKQVVSHIQIHTAPAITpntsSSV-SALVKSLNELQ-SWDWHGA 155 Pseudoalter...
WP_015884246      86 ADPRYGIASTDEDGRAVAVADVRRALDVARRAAELSGRQRVRAVEIHSAPRDG----GGSaTALAASLAELL-SVDGAGA 160 Beutenbergi...
jgi:Sked_06690   100 DHPAYGLSSADLDARRAALDDLAELRDLAQRLSDDAGRPRLTAVELHSAPGPG----LGTlAAFRESLDEVL-AWDLGGA 174
WP_012085493      93 TDPAYGLSSTDPGSRARALADLARARDLALSLAEGSGRRRVVGIELHSAPGPR----AGSlDALARSLEEVL-SWDLAGA 167 Kineococcus...
jgi:Celf_3350     77 DEPGYGLASHEPEHRALALGDVARARDLARTLADRHGRRRVAAIEVHTSPGPL----RGApDAFARSLEEIL-GWDLAGA 151
WP_013170952      76 ENSGFGLASNDGGGRAAALDYLLNASWAIKEVNDAANRQVFTHVALHSAPTGG----AHA-DAFARSL-EVAsQWDWDGA 149 Arcanobacte...
cebbi:ckrop_1874  93 KNPAFGLASADEDGRAAALEFTDRICKAVQELASRTGRSVIKYVQLHSAPTRG----AHS-DAFARSLDEIA-TWNWSSA 166
Q6NJR2            77 DGGTFGLASPDDDGRNAAIAFTRSIIDSARALDDAAGHRVIAGIHIHSAPSVT----ANR-DQFLRSLTELLeGMDNDDP 151 Corynebacte...
WP_014401484      81 SSPTFGLASPVAEGRQAAIDHALIAVERAHRLNDLTGQRTISTLHVHSAPSVT----AQE-DAFAQSLSEL--KDRGLGL 153 Corynebacte...
WP_014845597      75 EEPNFGLASTDDEGRRAAVEWVTGVRRAAEELNQQTGEETVSFVHVHSAPGVR----ASA-EAFQRSLADLE-ADDGFRA 148 Arachnia pr...
WP_012135716      83 ENRGFGLASSNEDQRQACVAYYRHLYQKITTINAASAGKVI-ALELHAAPQADnpnvAQAtDAFARSVKEIA-GWDWP-C 159 Citrobacter...
CBL55737         101 DDPAFGLASTDPAGRNRALDLLQQARHSIARMTER--GQHVLALEVHSSPTHRdnvdGTS-QEFAASLAQAA-DWDWGET 176
Q21DP8            78 KNPNFGIASDDQAGREEALAFMAKARDAIAKLNAHCGKQVVTAIEIQTAPNRSva-hSSA-ESLKASLTTML-GWDWQGA 154 Saccharopha...
Q3ID17           156 KLIIEHCDAYIQNQSSEKGFMRIEDELLAIATV--NKQan-nKLGITINWGRSAIEAQSATGPLHHMQLCINENLLSGLI 232 Pseudoalter...
WP_015884246     161 QLAIEHCDAARPGRRPEKGFLEIEDELAAIDAV--DDP----RVGLTVNWGRSAIEGRSASTPEEHVALAASRGRLAGLM 234 Beutenbergi...
jgi:Sked_06690   175 RLLVEHCDALVDSQQAVKGFWPLHDELTVLQSLagDVPevasRLGLSINWGRSAIEGRSARTPVEHVRAAAEAGLLRAVV 254
WP_012085493     168 GVVLEHCDALLPGATPAKGFWPLEEEIALVQGF--GLPp--eRLGLGFNWGRSAIEGRGPALALEHVRTLAATGLLRSVV 243 Kineococcus...
jgi:Celf_3350    152 ELLVEHCDAHVPGQAPAKGFLGLDEELAVVRSF--GLPp--dRLGMVVNWGRSAIEGRDTTTPVAHTRTVADEGLLRLLV 227
WP_013170952     150 RLVIEHQDEFIEGQDPQKGFLSLADEMRVAADH---------GIQVVINWGRSAIEGRNPDTPLAHVQVAGDAGVLGGVI 220 Arcanobacte...
cebbi:ckrop_1874 167 RIVIEHCDAPREDHEPEKGFLELADECAIAADH---------GVKLHINWGRSCLEDRDATTPLQHITTARDKGVLSGVM 237
Q6NJR2           152 RLIIEHCDRYNEAVTGEKRFLSIEQEIAIAKET---------GIGITVNWGRSAMEAYDTQLPARHIQALVAEGVFEGVM 222 Corynebacte...
WP_014401484     154 DLVIEHCDAYVPEYPGEKRFLTLETEARIAREL---------GLRVTVNWGRSVIESRDAGRPREHVEKLVAAGVLGGVM 224 Corynebacte...
WP_014845597     149 EVVIEHCDAYSPIFPGDKRFLSLITELAVADEY-----------GFAINWGSSALEWQNPNRPRQHVEILAEAGRLRGLI 217 Arachnia pr...
WP_012135716     160 DLVLEHCDA-MTSAAPRKGFLPLDNVLEVIADY---------DISVCINWARSAIEGRNTTLPLTHTQQVKQAGKLGALM 229 Citrobacter...
CBL55737         177 ALVVEHCDAARSSGGASKGFLTLDEEIDAVETV--RALsprtPVMMSINWGRSAIDTRNAGGPLTQIDRLRRHGLLAGVI 254
Q21DP8           155 RILVEHCDTFLTGQKPAKGFLTLREELAAINDV--NQAlg-aNVGVVINWGRSVIETRSTRGALDHIEQAKAAGLLAGLM 231 Saccharopha...
Q3ID17           233 FSGASSTSALYG-AWKDSHMPPVMNDFDqlNNKDSELSEHQIKKCMQLQQSAKLdFVGCKISILPHQQPLASRIQY 307 Pseudoalteromon...
WP_015884246     235 FSGASAVAGVGGgAWEDWHVAPRGAGPTpdDWRDSLLDADRMRRTLAACAGTAPsYVGMKVTAGPASRSVAERVEI 310 Beutenbergia ca...
jgi:Sked_06690   255 FSGAAATPTPWGaAWEDQHIAPRADDPAlrLSEGSLLGAEEIAETLAAAQGSALdVVGIKVTVRPDTADAQDRVAV 330
WP_012085493     244 FSGATGEESPWSpPWADTHIPPRGDDPAlaVSAPSLLGVEEIAATLRAAGDVP--HVGLKVAVRPEDADVATRLAV 317 Kineococcus rad...
jgi:Celf_3350    228 LSGATDADTAWGpAWGDMHIPPRGEDPAlaASSASLLGPSEIAATLAAAGDVP--RIGLKWAARPHDAGVAARVAL 301
WP_013170952     221 FSGAHDQPNSFGpAWNDDHVPLHEDEPT------SLMTAARVDAVATAARAYPVsLLGAKVSI-GADVPLSTRLDM 289 Arcanobacterium...
cebbi:ckrop_1874 238 FSGAGDKDTQYGyPWVDGHLPAYPDEPT------SWMTPDRIRECAHAALGTPEvYLGAKVCV-PSDSSLNGRVAM 306
Q6NJR2           223 FSGAGDKENTFGaAWADLHLPHHVDEPA------SLMDDDRIAECLSAAGGAQK-YHGAKIQA-PADVDVATRVTM 290 Corynebacterium...
WP_014401484     225 ISGAGGEDSVYGpGWADTHLPLVETEPV------SWLTPDRVVECVEAARGHAS-YYGVKVQV-PPTSSVSERLDI 292 Corynebacterium...
WP_014845597     218 FSGVAAVDTRWGrAWADLQLPLSTDEPA------SLMTPRRVTECLDLAGDQVA-YLGARVKA-PANADVEARLGL 285 Arachnia propio...
WP_012135716     230 FSGTT-QSGEYG-EWQDLHAPFAPFCPD------SMMTQEHARELLTCAGTDVLqFMGIKLLEINANADVSHRVAI 297 Citrobacter koseri
CBL55737         255 LSGASDRASSYGaPWTDAQLPAAAPDGS--GEASSLLTPQRAVEAMERAGDHLL-FDGVTFAIMPQWTPSQERLRY 327
Q21DP8           232 FSGVSDQDTEYG-AWQDTHMPAAKAANGtiGAEGSLMTEAEMHACMRAAGDVP--ILGIKLGVRPKDAPLEDRLGY 304 Saccharophagus ...
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