Conserved Protein Domain Family
AKR_ARA2

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cd19164: AKR_ARA2 
D-arabinose 1-dehydrogenase (ARA2) and similar proteins
ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Statistics
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PSSM-Id: 381390
Aligned: 15 rows
Threshold Bit Score: 382.01
Created: 16-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        ###                                 #    #                   
Q04212      2 VNEKVNPFd-LASVSPLVLGGAILNQqytd---epeSIPLEDIIKYAFSHGiNAIDTSPYYGpSEVLYGRALSnlr-nef 76  baker's yeast
ODV88823    1 MVQQEVSVs-KKDIPRLFIGGAVFNFqytq---hpeQVPVADLLQIAYDRGiRGIDTSEYYGpSEVLIGKALKkl---nl 73  Tortispora caseino...
OLL27169    8 SVQHPVLTnlADGSLPIVLGTGTFSLqyst---tpnAIPVQDILTRAFELGvRAIDTSPYYGdSEILLGKALRslv-nsw 83  Neolecta irregular...
ORY87650   10 AIPVPSKLt-LKTLGPLTFGAGTFSGryd-----nrDCDPVQLVKAAYELGiRQFDTSPYYGeSETLLGNGLQalfetgv 83  Protomyces lactuca...
EFJ03390   11 APGDRVAVl-EDGIPALVFGAACFSHfyadeatlksSSLPADTVRIALRYGiTAFDTSRYYGeSEVVLGEALKava-def 88  Schizophyllum comm...
KDN53442  119 QHNKKGTPp-QAGISPLIFGAGTFGTgqyssddlmmSIEPVRALRIAFRYGiNTFDTSPYYAnSETILGRALSvla-pef 196 Tilletiaria anomal...
EOR01134   49 DDLSEPVEp-APLKRSLIAGCGPLGRnytps-siyeSAAPVEAVKVALDNGvRAFDNAPHYApAEAVLGRALNile-plh 125 Wallemia ichthyoph...
PRP74683   18 KKTEGVACs-FDHLPPISFGAATFGNaysqd-dhlhSQTPLKAVRLALRYGlAYFDTSPYYGhSEEVLGGVLDslr-def 94  Protostelium sp. J...
OZJ03879  208 PAPWAVSKs-PLQVSPISFGAGVFSGnyetv-eqlpRIKPVEAVVRALERGiNLFDTSPYYGdSEKILGDALKkvs-nay 284 Bifiguratus adelaidae
ODQ53705   10 PVAAPVNGssLAGMSPLCFGAGTFAPqyn----epaLLRPTDVVRRALDLAvNCFDTSPYYGeSEIILGDALQnls-ady 84  Saitoella complica...
Feature 1              #                                            ##                        
Q04212     77 PRDTYFICTKVGRIga--eeFNYSRDFVRFSVHRSCERLh-----TTYLDLVYLHDVEFvk------------------- 130 baker's yeast
ODV88823   74 PRNDLYIATKTGRIai--dqFDYSPEHIEMSVYRSLERLg-----IDYLDQVLAHDVEFap------------------- 127 Tortispora caseino...
OLL27169   84 PRDRYYLATKCGRIsq--dkFDYSKDWIEKSVYRSLMRLn-----TEYLDAVMCHDVEFvs------------------- 137 Neolecta irregular...
ORY87650   84 ERDDVFVMTKCGRYdv--wdFDYSPDNIVRSVKMSCKKLh-----VAYLDVVYLHDVEFvt------------------- 137 Protomyces lactuca...
EFJ03390   89 PRESYQIMTKCGRIag--stFDYSPAGVRASVLRSLERLq-----TTYLDTVYLHDIEFvatpcaprtegnhfgalgsea 161 Schizophyllum comm...
KDN53442  197 PRSTYYISTKAGRYgpktsdFDYTPQRVRRSVCESIVRLnmqldhDGWLDNVYMHDVEFvctrvgkahdagmgaadvvgl 276 Tilletiaria anomal...
EOR01134  126 PRHTYTLITKVGHYgd---eVNYSEARIHESLRRSFAYLn-----TDYLDIVYLHDVEFvaeaiadineagqptrvld-- 195 Wallemia ichthyoph...
PRP74683   95 PRDSYMIVTKTGRYglkkqdFDYSPQRVKESVKESLRRLk-----TDYLDLVYLHDVEYvadldaddlkegvrdpsdl-- 167 Protostelium sp. J...
OZJ03879  285 PRSCYYISTKVGRYgyrkcdFDYSSQRVRTSVEESMRRLh-----TDYIDIVYCHDVEFvd------------------- 340 Bifiguratus adelaidae
ODQ53705   85 PRNTYYISTKCGREpt--neFDYTPSWIRKSVERSLERLh-----TSYLDVVYVHDVEFkt------------------- 138 Saitoella complica...
Feature 1                                                                          ##         
Q04212    131 --------------------------------------------fpDILEALKELRTLKNKGVIKNFGISGYPIDFITWL 166 baker's yeast
ODV88823  128 --------------------------------------------reDVLVGIGRLFELKDKGLVHRVGVSGYPLDVLLDI 163 Tortispora caseino...
OLL27169  138 --------------------------------------------deQVLDALCVLFKLKEKGVIRNVGITGLPLERLLHL 173 Neolecta irregular...
ORY87650  138 --------------------------------------------esQVDEAAKTLFELKSTGLVRHVGISGYPLDVLVKY 173 Protomyces lactuca...
EFJ03390  162 hkydlvadsahsgplpsatsqglpdeaafydlapgdaakirgpgdeQILAAFAELRKLKSEGLVRRIGITGYPLPILLRL 241 Schizophyllum comm...
KDN53442  277 gsdvlsa-----------eeqealrtdmglaetfeaaskvhgegdeKILGAVRELFKLKDEGKIKMAGISGYPLPVLLRL 345 Tilletiaria anomal...
EOR01134  196 ---------------------------nlqkynltgeprilgkgdeEVLNALRILNGYKKKGKIRNIGVSALPLPTLLRV 248 Wallemia ichthyoph...
PRP74683  168 ----------------------------kflademslarsrgpgdeKIIQAAATLFQLKDEGIIRNVGISGYPLPTLLRL 219 Protostelium sp. J...
OZJ03879  341 --------------------------------------------reDVQTALKELFQLKAEGKIGHVGISGYPLPVLSQI 376 Bifiguratus adelaidae
ODQ53705  139 --------------------------------------------edEAVLAVKTLFELKQEGKILNVGFSGYPLPVLVSL 174 Saitoella complica...
Feature 1                        #                                            #######         
Q04212    167 AEycsteesdigSLDAVLSYCNLNLQNnKLLNFRERLLRNak----------------lKMVCNASILSMSLLRSQet-- 228 baker's yeast
ODV88823  164 AVrark--mygrPLDVILSYCHYCLHNtTLLARVEEFKAAg-----------------vDVVINASLLSMGLLRNApp-- 222 Tortispora caseino...
OLL27169  174 ANlard--tfnkPLDLILTYTKFTLQNtTLKKFLPKIHGAg-----------------vKVVLNAGALSMGMLRPQgp-- 232 Neolecta irregular...
ORY87650  174 ANavkt--tagqSLDLILSYSQYNIQNtTLTKVIPRLLQEag----------------vEHVLSASPLSMGLLRTTgp-- 233 Protomyces lactuca...
EFJ03390  242 AIlira--tqgaPVDALLSYCHLTLQNaTLAGFLPHLLRRag----------------vKTVLNASPFSMGLLTSAga-- 301 Schizophyllum comm...
KDN53442  346 ARmvatn-ppfrPLDSILSYSNHTLHSdLLPAYIMLFECNpfrfpgapteaaagtewtpPFIMNASPFSMGLLTEAgp-- 422 Tilletiaria anomal...
EOR01134  249 SRlaish-lgkdSLQYVMSYANHGPQAlAPPSYIQTNFEAfegl-----------fddsISLVTASPFAMGLLTPQgp-- 314 Wallemia ichthyoph...
PRP74683  220 SIlirh--rlqrPLDAIMSFSHSNLQNySLANYTPHFHDSag----------------vKNILTASPLNMGLLTERgp-- 279 Protostelium sp. J...
OZJ03879  377 AAyqde---igqPLDVVLSYCHYTLQNsCLAEYIPSFQAQd-----------------vKYIFNASPLSMGLLRSWadnv 436 Bifiguratus adelaidae
ODQ53705  175 AErivk--evgkPVDAIITYSNFNIANtVLLKYLAKLSPCv------------------GQIISASPFSMGLLSSRep-- 232 Saitoella complica...
Feature 1                                                                    #                
Q04212    229 rqFHPCSHELRECASQAAKYCQEQnv-----------------------------------dLADLATRYAISew----- 268 baker's yeast
ODV88823  223 peFHPASADLKAAVAAAASEIKQKyn----------------------------------inLGDLALRFALKt------ 262 Tortispora caseino...
OLL27169  233 plWHPASAELRNAAQKACEWAQNHdn-----------------------------------dIASLALRFVFThw----- 272 Neolecta irregular...
ORY87650  234 peWHPASAFLKGKVQESIEYLQSLppteqvg-------------------------kevawtLPNVALGFALRhap---- 284 Protomyces lactuca...
EFJ03390  302 pgWHPAPKGLREAQAKATRALDAEgt-----------------------------------dLADVALGYSLRag----- 341 Schizophyllum comm...
KDN53442  423 ppWHPCSEQLRLARQESLRLLSGTgtlsgfdigqgesnadaasssnrtsdsarqsrlstptsLAETALQYGIRgserrad 502 Tilletiaria anomal...
EOR01134  315 pdWHPAPDGLKDTAKRTVKALGQE--------------------------------------ASKAAASFSMR------- 349 Wallemia ichthyoph...
PRP74683  280 psWHPSPTGLRDTAHRAADMCRDRgt-----------------------------------tLMKVAEGFSMRwdefvgr 324 Protostelium sp. J...
OZJ03879  437 piWHPAPPECRETVAKCAQIPKAKgi-----------------------------------aLADLASRYSFDavkfkpy 481 Bifiguratus adelaidae
ODQ53705  233 pkWHPGSPALKAAVAKAAAFCDVElr----------------------------------epLADLATRFALEk------ 272 Saitoella complica...
Feature 1                                       ####    #  ##              
Q04212    269 ----------------------------vgKGPVVLGVSSMEELKLALDNYEIVKSNGNRL 301 baker's yeast
ODV88823  263 -----------------------------wQGPSIIGCLSSEEVTVAAESAGSAPGTSSPE 294 Tortispora caseinolytica NRRL Y-17796
OLL27169  273 -----------------------------tESANVTGIGSVNELEVCVQEYWRAQKKDSEE 304 Neolecta irregularis DAH-3
ORY87650  285 ---------------------------edgIRSTVIGFTAVSEIRESVESYWQSLQPASEA 318 Protomyces lactucaedebilis
EFJ03390  342 -----------------------------aGVPLVVGLSNPREVHENVRVWREVTKATSAE 373 Schizophyllum commune H4-8
KDN53442  503 pssy----------------qaqrwgshvpHLRTLVGLANVEQVHIAVQAFRTLLAGAPAQ 547 Tilletiaria anomala UBC 951
EOR01134  350 ------------------------------KYTTVSGWQNADEVKQGLEAYHDSKASESDL 380 Wallemia ichthyophaga EXF-994
PRP74683  325 t----------------------tgksggpPSTVVVGLSNPREVHEAVDVYVSLKKKEERE 363 Protostelium sp. Jena Gg-2016a
OZJ03879  482 hlltgsvvldhchlpspppeaidvdgaessITSTVIGLETPQEVESAYATWSLVQDRQLGI 542 Bifiguratus adelaidae
ODQ53705  273 -----------------------------wEGVTLVGCSTVDEVDSAVANWWKCQDKAQKE 304 Saitoella complicata NRRL Y-17804

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