Conserved Protein Domain Family
modD_like

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cd01573: modD_like 
ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and eukaryotes. They catalyse the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide.
Statistics
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PSSM-Id: 238807
Aligned: 16 rows
Threshold Bit Score: 315.008
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitedimerization
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
ZP_00149656   8 DRALEALLADDApqGDATTFALGigdQPGRMVFRARYDMVLCGSEEARRMGELRGlkASGLIAaSGSALqaGQIILTLEG 87  Dechloromonas ar...
ZP_00004620   6 DVALHCLLKRDRhpGVTVAEATShdsRGMTVTLRAGAAGTVCGLEEAERIFTLLGc-AVDIAAaSGARVetDDLLVAARG 84  Rhodobacter spha...
Q57278        6 DKELDDLLLEDIyrGDLTTHALSienIPAKILFKRKNAGVVAGVSVAEKLLKKLDi-QPHLYVkEGEWVesGALLISAEG 84  Haemophilus infl...
ZP_00149061   2 IEEFEHYLLEDCpyGDETTELLGi-eGEGSLTIRSRDPGIASCADDLAEFYEKKGl-KVNMHLeNGKEFteNAILFEAEG 79  Methanococcoides...
NP_954005     7 DSELDRFFEEDCpyGDLTTHLLGigrQKGRITFSTREETVLCGTEEAGRLLDRCGa-RVGRMEeSGTRLsaGVEFLVADG 85  Geobacter sulfur...
NP_661354     7 DSEIERYIEEDVpyGDLTTTLLGigdEPGEITFTTRDRTVLCCTEEAGRVLAKCGa-EVLSMLpSGTIAapGTEILRASG 85  Chlorobium tepid...
NP_987636     7 DYELEKIIEEDInpLDLTSQIMKldrFNAKLAYKARHDMVLCCTEEAERICKILGl-EVISYKrTGSYVkeGEVFFEAKG 85  Methanococcus ma...
ZP_00097540   6 RDEIDRWLKEDVpyIDLTSWTLGireQQGSIAYFTREEAVVCGTEEVRQIFDHLHi-ETDRFIpSGQQVkqGEVLISGKG 84  Desulfitobacteri...
AAF13762     16 TGLIENLWMEDAgyGDLTTRSLGiqdHPAHITFTARDEQIASSVEEAAALLKQLGa-SIDYAIpSGSRAlsGTLLLEAKA 94  Zymomonas mobilis
NP_907923     3 NQEIERLWREDAdyIDWTTLGLGigeKRGEISFSAKRGGVISGIKEALSLGEACGv-ELEALVkEGAWVeaGEEILRGEG 81  Wolinella succin...
Feature 1                                                   ###                    ##           
ZP_00149656  88 SAsGLHMVWKTAQTLIEYLSGIASSAATILAAArvanPDIGIACTRKNFPGTKAAAIKAILCGGASPHRLSLSETLLVFA 167 Dechloromonas ar...
ZP_00004620  85 PLaSLTSGWQPAQSLIEWASGVATATADFVAAAraanPGIVVACPRKAIPGARPLALKAAVSGGAVVQLGASPTPTLILA 164 Rhodobacter spha...
Q57278       85 MSeQLHQAWKVVQLVLEWSCGVAQYTAEMIANAksvnPTAVVACTRKSIPNTRKLATNAVLAAGGHIHRQGVSETLLVFT 164 Haemophilus infl...
ZP_00149061  80 DLrKLFKLWRISQTFLSMTCAIATKTRKMVDKArevnPDIMIATSRKTHPGFRKYELRSVHAGGGDHHRNSLSDSILITQ 159 Methanococcoides...
NP_954005    86 EAgSLHAGWKVALNLLEYASGIATRTARIIAVAravnPAVVVTTTRKSFPGTRKISIKAITAAGAVPHRLGLSETILVFR 165 Geobacter sulfur...
NP_661354    86 PAaALHAGWKVAMNLLEYASGISTRTATIVERAraanPGINVVTTRKSFPGTKKIAMKAIMAGGAFPHRLGLSESILVFS 165 Chlorobium tepid...
NP_987636    86 RAdNVHLAWKSVLRLLEGYCGMATRTYEFVTLArkynENTNVVTTRKNLAGTKKPTIKAIVAGGAYPHRLGLSETILIFD 165 Methanococcus ma...
ZP_00097540  85 RAeDLNMAWKVGQNILDHCSGIATKTRRMVDDAksinPKVAVLTTRKGFPGTKALTTKSIMVGGALPHRLGISETILIFK 164 Desulfitobacteri...
AAF13762     95 SAgQLHLGWKSAQSLMEWSAGIATMTHKMVTLAkkisPMAVVGCTRKAPPLTRPLAVKAVLAGGGVMHRINLSETLLVFA 174 Zymomonas mobilis
NP_907923    82 KAiALHKAWKVTQNLLEYLSGIATFTHEMVTCAkkinPSIEILTTRKNFPGSKRLMLQAILSGGAWPHRLGLFDSVLVFE 161 Wolinella succin...
Feature 1                                                          #                         ## 
ZP_00149656 168 EHRAFLDneap-aatvRRLRRqwperAIVVELAdEDEALLWARagaDILQLEKlspeaVTRLRQTLgdc--paRIAAAGG 244 Dechloromonas ar...
ZP_00004620 165 EHFAFEGaasv-rdrvAQMRQtdpgrAVAVEVEtLAHALAAADlgaDMIQLRKmrpeeVAATARSLdrg-wtgQLIAVGA 242 Rhodobacter spha...
Q57278      165 NHRNLLSdpndwtkivDRLRQeapenKITLEADnYAQFEQMYMaepDIIQLDKwlledVKKALDLLqskqkdiLLSVAGG 244 Haemophilus infl...
ZP_00149061 160 NHFNVVGs-------fDKLRAm---rKIEIEPRtKEEVFQYAPi-aDILLLDHytpeeLKEVAPKLrqi-npkLELAVGG 227 Methanococcoides...
NP_954005   166 QHTAFLGglepflgmiGDLRKrapetAIMVEAEsVADAVAVAAagpDVLQIDKvapadLSALVPQLrklapmtRISAAGG 245 Geobacter sulfur...
NP_661354   166 QHTVFLGgldpfldklSDLKKlapeqKILVEADsAVEALRIAAagaDVVQVDKmpvaeLAALVSEIrsrfpgvAVSAAGG 245 Chlorobium tepid...
NP_987636   166 EHLAFVDgdeelkcvlKEMKAnalekKIGIEVDnFETGIKYVKmgfDYIQLDKvdsktVEKFVKAAkeinpniTIVAAGG 245 Methanococcus ma...
ZP_00097540 165 QHMNMIGgfeallkklPEIKGeccekKIIVEAGsLEQTVSLCQagvDGIQFDKlkseeLKNAVKYLraefphvVALAAGG 244 Desulfitobacteri...
AAF13762    175 EHLTFMNfdig--kaiGRLKQtaperKITVEVEtIEQALTVAQfspDILQLEKftpqqLHHLHERLkffdhipSLAAAGG 252 Zymomonas mobilis
NP_907923   162 QHRVFLEtpaeleqafKALKRrllekKIAVEVSdFEEAKLFASwgaDILQCEKmelgeLARCVELKray-pslLLSATGG 240 Wolinella succin...
Feature 1                        # ##  #          
ZP_00149656 245 InsANAEAYARAgADILVTSAPYFapPRDVAVTL 278 Dechloromonas aromatica RCB
ZP_00004620 243 IpiSLAAAYATSgADVLMTSMPYHapLADIRVAF 276 Rhodobacter sphaeroides
Q57278      245 VnkNNVSDYAKLgIRLFITSAPYYvpPEDIKVVI 278 Haemophilus influenzae
ZP_00149061 228 IsfENIPKYAAS-VDFVVTTAPFYaePFDLTTNI 260 Methanococcoides burtonii DSM 6242
NP_954005   246 IneSNAAVYAATgVDILVLSSAYFgrPADIGVRL 279 Geobacter sulfurreducens PCA
NP_661354   246 IngENAAAYAATgIDIIVLSSVYFgkPADISTSI 279 Chlorobium tepidum TLS
NP_987636   246 ItiQNIEEYAKTgAEVIVTSALYFgkAADIKTII 279 Methanococcus maripaludis S2
ZP_00097540 245 IneANVRDYAETgVDGIVTTSLFSakPLDIGVKI 278 Desulfitobacterium hafniense
AAF13762    253 InpENIADYIEAgADIIVTSAPYYakPCDVQVKL 286 Zymomonas mobilis
NP_907923   241 VkiENVMKIAQSgVDFVVTSAPYHanPLDIKVRM 274 Wolinella succinogenes DSM 1740

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