Conserved Protein Domain Family
2A0111

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TIGR00890: 2A0111 
oxalate/formate antiporter family transporter
This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Statistics
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PSSM-Id: 273323
Aligned: 5 rows
Threshold Bit Score: 305.525
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAC43722      16 RWFYLVLAVLLMCMISGVQYSWTLYANPVKDNLGV--S-----LAAVQTAFTLSQVIQAGSQPGGGYFVDKFGPRIPLMF 88  Oxalobacter for...
P05715         4 RAWYLAAGFVIMCFNSLYQYTWNLLAPMIGRAMGL--G-----VLAEAVGFTIYVIVSTVAQPAGGALADLRGPRGVGAL 76  Thermoproteus t...
P37662         9 TRWLTLIGTIITQFALGSVYTWSLFNGALSAKLDA--P-----VSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMA 81  Escherichia col...
WP_010923780  13 RWMLVVGATISMALVSVYEYSWTLYTVPLGRVFHVapG-----SPALGLTYTIYIIVQALSMFVAGRIADRYGPRLISML 87  Sulfolobus solf...
E88130        16 RPWAVLVGGVMCMVTFGIVYTCGNLLPYLVSYFRW--KmypdmRTGQLIWLQTLLSGLPMGMVIGGLVERKFGGRAGALL 93  Caenorhabditis ...
AAC43722      89 GGAMVLAGW--TFMGMVDSVPALYALYT-LAGAGVGIVYGIAMNTANRWFPDKRGLASGFTAAGYGLGVLPFLPLISSVL 165 Oxalobacter for...
P05715        77 SAVLSALGF--IGAALAPGPALLYLAWG-LGSAGEGVLYGIAFNLAVKWYQDKLGLATGLVSLGFGLGSAVANPLIASVG 153 Thermoproteus t...
P37662        82 SGILLGLGF--FLTAHSDNLMMLWLSAGvLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLL 159 Escherichia col...
WP_010923780  88 GGIITGIGY--ISSAFAKSLPILYLTYG-FGSIGVGIIYGTAISTAVKWFPDKRGLATGIIEIGFGGGSFALSPLIQYII 164 Sulfolobus solf...
E88130        94 GSIIYTIGVgsTFYSIQHSYAATLLTMGgIASVGSSIAYSSILPTAQRWFPDNVGLAGGIIIGGYGCGAFILSPLQTTFI 173 Caenorhabditis ...
AAC43722     166 k-----------------vEgVGAAFMYTGLIMGILIILIAFVIRFPGQqgak------------kqivVTDkdFNSGEM 216 Oxalobacter for...
P05715       154 -------------------N-YREATLAIGVVELLVLVPLSLLVDYPRG--------------------LSG--VSPRRA 191 Thermoproteus t...
P37662       160 e-----------------tVgLEKTFVIWGAIALLMIVFGATLMKDAPKqevk------------tsngVVEkdYTLAES 210 Escherichia col...
WP_010923780 165 t-----------------sIsYTAAFTYMGIVQLIVITLLAFFFAYPPPqwlpkgfnaeeyekkrkmikRSKndYTVSQM 227 Sulfolobus solf...
E88130       174 npldyrvndqgfftqedllErVPYVFIVMSIFFTVFQSIGLIFIGQPEGdihveten-----ligtnseIRVeqARVWPQ 248 Caenorhabditis ...
AAC43722     217 LRTPQFWVLWTAFFSVNFGGLLLVAnsvpYgRSLG-LAAgVLTIGVSIQNLFNGGCRPFWGFVSDKIGRYKTMSVVFGIN 295 Oxalobacter for...
P05715       192 LLDARFWTLYASYALGAVPLLSLAS----S-LHLL-VGGgELVLLASLYPLLVGAARPLLGALADKWGPLKAIYLALAVS 265 Thermoproteus t...
P37662       211 MRKPQYWMLAVMFLTACMSGLYVIGvakdIaQSLAhLDVvSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVIS 290 Escherichia col...
WP_010923780 228 VKTWQWWVIYIAFFLIAGSGLSIIGhlipYgRSLG-FSI-AAVIAVFLFPFANGLGRFVMGTVSDYLGRPYTMTLSFGIS 305 Sulfolobus solf...
E88130       249 LRTTTFLVLFLSLTCNAVWVQLTSGlykaYgQQFI-DSDfFLSLIGSISSIFNAGSRVFWGAIADTTSYQFSMSIVCSLG 327 Caenorhabditis ...
AAC43722     296 AVVLALFPTIAAL-GDvafiamLAIAFFTWGGSYALFPSTNSDIFGTAYSARNYGFFWAAKA-------------TASIF 361 Oxalobacter for...
P05715       266 AAGTLAMLAGLDI-VG------VIAVGLTGGAIIILYLNLSSRIFGPKYATANNGLLYTAKA-------------VGGTL 325 Thermoproteus t...
P37662       291 LVGMAALLFAP-L-NAvtffaaIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFG-------------IGSIC 355 Escherichia col...
WP_010923780 306 GISMLSIAFIPKI-ASlyl-alIFLTAFTWGPLFSLFPPLVGDYYGPKHSGANYGLTYTAKA-------------LAGIF 370 Sulfolobus solf...
E88130       328 AVLAFSMPLVKMVsNDvlflatVCLMFSCIGGTFSIFPYITHKCFSKANFSVMYGFLQCAVTgyrireymntfqsVAGLI 407 Caenorhabditis ...
AAC43722     362 GGGLGAAIATNFGWNTAFLITAITSFIAFAL 392 Oxalobacter formigenes
P05715       326 GSAAFGYVYALGGARASLLFAAASALAAMAI 356 Thermoproteus tenax
P37662       356 GSIIASLFG---GFYVTFYVIFALLILSLAL 383 Escherichia coli K-12
WP_010923780 371 AGYGASILFTSYGIKETLIITGSMAIMSAIL 401 Sulfolobus solfataricus
E88130       408 AGLISTHALSEIGFEYLFIVCGCFMLTSLFL 438 Caenorhabditis elegans
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