Conserved Protein Domain Family
PRK07246

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PRK07246: PRK07246 
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated
Statistics
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PSSM-Id: 180905
Aligned: 38 rows
Threshold Bit Score: 1402.12
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
288905684   9 MQVNSQKYAIVDLEATGAHAMAEIIQVGIVIIENDEIVKTYQTDVNPHEALSEHIINLTGITDEQLAKAPDFSQVAQEVF 88 
225861294   1 MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIF 80 
169833275   1 MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIF 80 
225858612   1 MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIF 80 
225854318   1 MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIF 80 
225856476   1 MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIF 80 
194397188   1 MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIF 80 
182683721   1 MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIF 80 
298503192   1 MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIF 80 
221231602   1 MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIF 80 
288905684  89 SLIEDCVFVAHNVKFDANLLAEQLFMEGYELRTPRVDTVELAQVFYPTFEKYSLGNLADALALDLADAHTAISDAYATAQ 168
225861294  81 DLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE 160
169833275  81 DLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE 160
225858612  81 DLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE 160
225854318  81 DLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE 160
225856476  81 DLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE 160
194397188  81 DLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE 160
182683721  81 DLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE 160
298503192  81 DLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE 160
221231602  81 DLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE 160
288905684 169 LFLKLKAKMKSLPKEVLESLLPLADNLLFETGMLIEESFKQAKVLSPKDFQEVGGLVLRQPKTIGEARQLSEAFDVNLAL 248
225861294 161 LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKTAASLEPRKLSQDFSKNISL 240
169833275 161 LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKTAASLELRKLSQDFSKNISL 240
225858612 161 LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKTAASLELRKLSQDFSKNISL 240
225854318 161 LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKTAASLELRKLSQDFSKNISL 240
225856476 161 LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKMAASLEPRKLSQDFSKNISL 240
194397188 161 LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKTAASLELRKLSQDFSKNISL 240
182683721 161 LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKTEASLEPRKLSQDFSKNISL 240
298503192 161 LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKTAASLEPRKLSQDFSKNISL 240
221231602 161 LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYFKKTAASLELRKLSQDFSKNISL 240
288905684 249 LGLDAREKQSQFAQLVKDDFQSSQISFLEAQAGLGKTYGYLLPLLQLAQDEQVIVSVPTKVLQDQIMANEVRQIQDVFHI 328
225861294 241 LNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHT 320
169833275 241 LNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHT 320
225858612 241 LNLEVREEQESFAKEVGLLLKDEPVFLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHT 320
225854318 241 LNLEVREEQESFAKEVGLLLKDEPFSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHT 320
225856476 241 LNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHT 320
194397188 241 LNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHT 320
182683721 241 LNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHT 320
298503192 241 LNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHT 320
221231602 241 LNLEVREEQESFAKEVGLLLKDEPFSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHT 320
288905684 329 PCQSIKGPGNYIKLDAFADSLRREGDNRLVNRYKMQLLVWLTETETGDLDEIKQKQRFEAYFDQIKHDGNLSEKSLYKDV 408
225861294 321 DIHSLKGPQNYLKLDAFYHSLQKNDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSQSLFVTE 400
169833275 321 DIHSLKGPQNYLKLDAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSQSLFVTE 400
225858612 321 DIHSLKGPQNYLKLDAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSQSLFVTE 400
225854318 321 DIHSLKGPQNYLKLDAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSQSLFVTE 400
225856476 321 DIHSLKGPQNYLKLDAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSQNLFVTE 400
194397188 321 DIHSLKGPQNYLKLDAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSHSLFVTE 400
182683721 321 DIHSLKGPQNYLKLDAFYYSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSQSLFVTE 400
298503192 321 DIHSLKGPQNYLKLDAFYHSLQKNDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSQSLFVTE 400
221231602 321 DIHSLKGPQNYLKLDAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSQSLFVTE 400
288905684 409 DFWNRTYENAKHSKLLIINHAYFLERVQDDKAFAAKKVLVFDEAQKLILNLEQFSRRRVNVTQLVQKLEKYLDAALPTLE 488
225861294 401 DFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQ 480
169833275 401 DFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQ 480
225858612 401 DFWKRSQERAETCKLLVTNHAYFVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQ 480
225854318 401 DFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQ 480
225856476 401 DFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQ 480
194397188 401 DFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQ 480
182683721 401 DFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQ 480
298503192 401 DFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQ 480
221231602 401 DFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQ 480
288905684 489 KRLIESLSFQLSHLATRFYQNQEVYVTTEDARRLEQTTNELLAFNpdwryicLEDLLALFaQPFTDFWFETIVENEKRQT 568
225861294 481 QRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEG-------FDELVRYF-TAEGDYWLEVTETSQKKIQ 552
169833275 481 QRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEG-------FDELVRYF-TAEGDYWLEVTETSQKKIQ 552
225858612 481 QRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEG-------FDELVRYF-TAEGDYWLEVTETSQKKIQ 552
225854318 481 QRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEG-------FDELVRYF-TAEGDYWLEVTETSQKKIQ 552
225856476 481 QRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEG-------FDELVRYF-TAEGDYWLEVTETSQKKIQ 552
194397188 481 QRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEG-------FDELVRYF-TAEGDYWLEVTETSQKKIQ 552
182683721 481 QRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVGG-------FDELVRYF-TAEGDYWLEVTETSQKKIQ 552
298503192 481 QRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEG-------FDELVRYF-TAEGDYWLEVTETSQKKIQ 552
221231602 481 QRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEG-------FDELVRYF-TAEGDYWLEVTETSQKKIQ 552
288905684 569 yLNASSEELLNFQEFLPETRKTYMISATLHISPQVSLADLLGFEHYHFMSIAHDKQNAQHIWIDEEMPNVADISEEEYAS 648
225861294 553 -ISSTKSCRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAR 631
169833275 553 -ISSTKSGRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAR 631
225858612 553 -ISSTKSGRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAR 631
225854318 553 -ISSTKSGRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAR 631
225856476 553 -ISSTKSGRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEVKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAR 631
194397188 553 -ISSTKSGRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAR 631
182683721 553 -ISSTKSGRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAR 631
298503192 553 -ISSTKSCRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAR 631
221231602 553 -ISSTKSGRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAR 631
288905684 649 AIAERIYQLKQLDEPILVLFNAKKTMLDVSDLLddmALHHLTQEKNGTAYNVKRRFERGESRILLGTGAFWEGVDFVQAD 728
225861294 632 EVAALLVEIQAFQQPILVLFTAKDMLLAVSDLL---TVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHP 708
169833275 632 EVAALLVEIQAFQQPILVLFTAKDMLLAVSDLL---TVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHP 708
225858612 632 EVAALLVEIQAFQQPILVLFTAKDMLLAVSDLL---TVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHP 708
225854318 632 EVAALLVEIQAFQQPILVLFTAKDMLLAVSDLL---TVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHP 708
225856476 632 EVAALLVEIQAFQQPILVLFTAKDMLLAVSDLL---TVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHP 708
194397188 632 EVAALLVEIQAFQQPILVLFTAKDMLLAVSDLL---TVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHP 708
182683721 632 EVATLLVEIQAFQQPILVLFTAKDMLLAVSDLL---TVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHP 708
298503192 632 EVAALLVEIQAFQQPILVLFTAKDMLLAVSDLL---TVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHP 708
221231602 632 EVAALLVEIQAFQQPILVLFTAKDMLLAVSDLL---TVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHP 708
288905684 729 KMIEVITRLPFENPKDLFVQKISNHLLAQAKSPFYDYSLPLAILKLKQAIGRTMRRDNQRSAVLILDNRILTKSYGKMIN 808
225861294 709 FVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIIGKRYGKQIV 788
169833275 709 FVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIV 788
225858612 709 FVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIV 788
225854318 709 SVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIV 788
225856476 709 FVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIV 788
194397188 709 FVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIV 788
182683721 709 FVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIV 788
298503192 709 FVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIIGKRYGKQIV 788
221231602 709 SVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIV 788
288905684 809 DALAEEFYLSSQKFSKSLTEIKNFLL 834
225861294 789 ASLAEEATVKTISRSEVDEAIDRFFN 814
169833275 789 ASLAEEATVKTISRSEVDEAIDRFFN 814
225858612 789 ASLAEEATVKTISRSEVDEAIDRFFN 814
225854318 789 ASLAEEATVKTISRSEVDEAIDRFFN 814
225856476 789 ASLAEEATVKTISRSEVDEAIDRFFN 814
194397188 789 ASLAEEATVKTISRSEVDEAIDRFFN 814
182683721 789 ASLAEEATVKTISRSEVDEAIDRFFN 814
298503192 789 ASLAEEATVKTISRSEVDEAIDRFFN 814
221231602 789 ASLAEEATVKTISRSEVDEAIDRFFN 814
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