ubiquitin-like (Ubl) domain found in ubiquitin domain-containing protein UBFD1 and similar proteins
UBFD1, also termed ubiquitin-binding protein homolog (UBPH), is a polyubiquitin binding protein containing a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. It may play a role as nuclear factor-kappaB (NF-kappaB) regulator.
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]
Evidence:
Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering), the other 6 lysines are not conserved in this family, for most the residue corresponding to K48 is a conserved Gly; may have other functions, for example in NEDD8 K27 is involved in the mechanism of protein neddylation
Jiyao W et al.(2023). "The conserved domain database in 2023.",