4X82


Conserved Protein Domain Family
ZIP4_domain

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pfam18292: ZIP4_domain 
Zinc transporter ZIP4 domain
This domain is found in ZRT1-IRT1-like protein 4 (ZIP4) present in Homo sapiens and Mus musculus. ZIP4 is a zinc transporter that allows uptake of the essential nutrient zinc. The domain is found before the N-terminal of ZIP Zinc transporter domain (Pfam: PF02535).
Statistics
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PSSM-Id: 465698
Aligned: 28 rows
Threshold Bit Score: 121.789
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4X82_A        13 GLLNTLAARVHCTS------GPCGKCLSVDDLLALGrpeepG----------HLARLSAAAALYLSDPEGTCEDIRAGRW 76  black flying fox
3_pfamImport   1 VLIGELLRAVHCAErtgasqDVCGECLTSEVALSVL-----EddgtayiteeDYHRISTVLLYYIINLQDLCVSNAAKSS 75 
XP_015209983  64 ALITALFDTVKCQEriagtqQQCNQCLAADVLLSVL-----NdeakdylteeDFQMISTVLLYYVINMRDLCTSNISTSS 138
XP_014427226  66 KLIKILLERTECPQwiygiqEDCNLCLEPDALLLIA-----GgdsedylseeIFQKISIILLYYIIHQKDICSSHLSLSN 140
XP_012406715  65 RLIQTLLEKTGCPHrihgkqEDCNLCLEPDALLLIA-----GgdfedhlseeVFQRISLLLLYYIIHQDEICASKLNLSS 139
XP_005564801  63 SLIKTLLEKTGCPRrrngmqGDCHLCFEPDALLLIA-----GgnfedqlreeVVQRVSLLLLYYIIHQEEICSSKLNMSN 137
XP_006254347  62 SLIKILLERTGCPQrtdgtqEDCKLCLEPDALSLTA-----GgdledelreeVVQRVSLLLLYYIIHQEEICSSKLNMSN 136
XP_021582343  63 SLIKTLLEKTGCPQktngirGDCNLCFEPDALLLIA-----GgdfedqlreeVVQRVSLLLLYYIIHQEEICSSKLNMSN 137
KFO74791      66 ELVKMLLERAECPQringtqEDCNLCLEPDALLLIA-----GgdledhlseeVFERISLILLYYILHQRDVCSSELSLNN 140
KFV64060      57 EVVRRLLERAGCPQqkagmqEDCELCLEPDAVLLTA-----GgaledrlseeVFERISLILLYYILHHRDVCSSQLSLES 131
4X82_A        77 ASRADhLLALL-----------EGPKALAPG-LSRLLQRIQaQTTGQPSAg-----EACVDPPQLLREAGVagaPGSPGP 139 black flying fox
3_pfamImport  76 SSLSF-ENYQFyllaltnlhpaENNLFLSSReAESILQLIN-EHYEPSNQnasadlQ-CVDAAHLLEDANV---HESAGA 149
XP_015209983 139 Q------DYHYylfavlninhqDDNQFLSQNeTETILQLIS-QHYRLSTS------SHCIDTSTLMEELNI---VDIQGA 202
XP_014427226 141 K------DYKFylhsmlslrrdENCYYFSRNeTEDILAAIR-QHFKIPES------Q-CVDVSIVEKAADI---LDSDGA 203
XP_012406715 140 K------DYQFylhsllslrqdEDCYSFSQNeTEDILASVR-QHFNPSRS------Q-CMETKILQQKSGI---ISNNGA 202
XP_005564801 138 K------EYKFylhsllslrqdEDSSFLSQNeTEDILAFTR-QYFDTSQS------Q-CMETKTLQKKSGI---VSSEGA 200
XP_006254347 137 R------EYEFylhsllslrqdEDSYFLSEKeTDDILASTR-KYFGTSTS------P-CMETKILQRESGI---QSSNGA 199
XP_021582343 138 K------EYKFylhsllslrkdEDSYFLSQNeTEDILAFTR-QHFDTSRS------Q-CMGTKMLQKKSGI---QNSDGA 200
KFO74791     141 M------DYKFylqsmlslrddEDHYYFSRNeTEDILASVR-QHFKTSET------Q-CVDVSALEKNADI---MGRDGA 203
KFV64060     132 K------DYKYylqsmlslrqdEDCDYFSRNeTEDTLAAVR-QHFKTPET------Q-CVDVSALEKKAEI---MDREGA 194
4X82_A       140 -------VLATLLEHVGRGSCF 154 black flying fox
3_pfamImport 150 gvssvpkLAAAIISHVLQGHCF 171
XP_015209983 203 dfkmvpkLCAAIITYTLRGQCF 224
XP_014427226 204 dentlprLAATIITLALQGVCL 225
XP_012406715 203 dentlprLAATIISLSLQGVCL 224
XP_005564801 201 nentlpqLAATIITLSLQGVCL 222
XP_006254347 200 dekmlpqLAATIIALSLQGVCL 221
XP_021582343 201 dehtlprLAATIIALSLQGVCL 222
KFO74791     204 dentlprLAALIITLALKGVCM 225
KFV64060     195 dantlprLAASIITLALQGVCV 216
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