Conserved Protein Domain Family
Sen15

?
pfam09631: Sen15 
Sen15 protein
The Sen15 subunit of the tRNA intron-splicing endonuclease is one of the two structural subunits of this hetero-tetrameric enzyme. Residues 36-157 of this subunit possess a novel homodimeric fold. Each monomer consists of three alpha-helices and a mixed antiparallel/parallel beta-sheet. Two monomers of Sen15 fold with two monomers of Sen34, one of the two catalytic subunits, to form an alpha2-beta2 tetramer as part of the functional endonuclease assembly.
Statistics
?
PSSM-Id: 462844
Aligned: 41 rows
Threshold Bit Score: 76.8888
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_007812814  19 TVLHNLADQHDWTCLEL--RDGPE--Q---PRSLIKGLPPKrlYLHPddqiaalaheeatgeklfqnpeYELVLPVHITE 91 
XP_004078937  40 LVCMDLTEVRRWKEVSS--VKSPEl-----rLILLEGKEKDgaPV-------------------------HTVLPLPAHQ 87 
AAI61671      39 LVYMDLTEVRKWKDVVG--VSCPEl-----qAVLLEGREKEgeSV-------------------------QMIYPLPSHR 86 
XP_005996264  56 LVYLDLLEARNWHDVAC--IGSEEl-----qLIYLQGCERAgdTP-------------------------QVVIPTPTHE 103
XP_002191153  72 LVYLDLLEGRNWHEVQP--VGVAEl-----qLVCLHARAKEqeGL-------------------------QVMVPVPAHI 119
XP_021260848  59 LVYLDLLEGRSWHEVKH--VGLAEl-----qLVCLHAREREqgDL-------------------------QVMVPIPADV 106
EEC10795      13 NVFKRLSEASDWWDVDA--KLCEEc-----gLRYIEGKSAKdsDP-------------------------TLLLPLPVDV 60 
EFX67900      20 QLYKDLKFVRGNEDVKI--HQFDEl-----dLVYITGYLPDaeRQQ------------------------EILLPLAADE 68 
XP_014568543  31 QTFADLTHSQGWRDLRVleLAGTD-------LCVLKGKAKAqnGAIE----------------------EKIVLPMVLTT 81 
XP_003323043  26 HAFSDLTAAQGWKHVKV--QTFPTgrPspsRLAILRGTPSPsgGE-------------------------RIVYPMSLHQ 78 
XP_007812814  92 TWSLSRFAAVFNSVPSNGa----rPKRILLATLHNDSTVVYYLMHEGMVKPRQ-N 141
XP_004078937  88 SLSHSSICSVLDR-----------GFPVLLCAVASDSTLVYQRLTDGLVTPEP-P 130
AAI61671      87 SIKHRELRSILDR-----------GSPMLLCAVASDSTLVYQRLCDGFLTPDPpV 130
XP_005996264 104 SLTHKRIREIMKHCCDQDsredvvKMSIVLAIVESDFTVVYYKLTDGFVVPDPpD 158
XP_002191153 120 LISHERLREILKKASLPPedp-dtLLSVTLAIVETDSTIVYYKMTDGFVMLDP-P 172
XP_021260848 107 LVSHERLREIMKKAALPQddp-dtPLSITLAIVETDSTIVYYKMTDGFVLPEPpD 160
EEC10795      61 AFNFEQIQKLLKCLp--------sKEKVVIALQDGDTSVVFYDVMPGIVRPLEfS 107
EFX67900      69 AISMKKIGEVQKCLfhr-----hkSSRLTLALMDSDSTTVYFGVTPGLLPPSDlE 118
XP_014568543  82 PTHMQTLQGVFAALPSR-------EESILVSIADSDSTTVYYKLGNGIVKPKEvP 129
XP_003323043  79 PTNFQTLSEIFPAIGLGP------GSKVLLAIVSSDSSIVYYELSEGIVSPKEvP 127
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap