Conserved Protein Domain Family
YjgF_YER057c_UK114_like_6
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cd06154: YjgF_YER057c_UK114_like_6 
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Links
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Statistics
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PSSM-Id: 100011
Aligned: 49 rows
Threshold Bit Score: 140.767
Created: 17-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ##  # #  # # ##                                      # ## # #       
AAF09626     33 IAGTSPWEDTvGYSRAVRVGnIVQVAGTTAtvdgevvgvgdAYWQTKVALGLIRQALEQAGARLEDVVRTRMYVpdisRW 112 Deinococcus radi...
YP_997696    14 IQSGSRWEELaGYSRAVVDGdDILVSGTIGqdfasgqfppsASAQCELALDTIEAALAQAQATLADVLRVRVYLadraDV 93  Verminephrobacte...
NP_436434     5 IFAGVPSEEMaGYAKAVIVGtTVYVSGTTGrdpdtgnfpdnAAQQARNALASIDKALRQAGGSLANAVVSRVYVvdqaCA 84  Sinorhizobium me...
ZP_01550267   5 ISSGSPFEKIgGYSRAIVDDdWVFISGTSGyvege-teaddAVGQTKKALEIISSTLAEAGGGLRDIVSLRVYVarreDI 83  Labrenzia aggreg...
ZP_01014481   6 ITSGSPFEAQiGYSRAVAVDgWVFVSGTTGydyatmempadVAQQAANALATIGKALAEAGGSLDDVVQVKYILpdgnDF 85  Rhodobacterales ...
ZP_02190826   6 IYSGAPFEEMaGYARAVVDPpYVFVSGTTGfdpetlqfpedVESQCENCFATIERALAKAGASLNDLVRIRVFVasraEF 85  alpha proteobact...
ZP_00053229   6 ISSGSSFEEVaGYSRAVAQDpWVFVSGTSGfkdgq--iadgVVAQAEQCIATIAGALEQAGSSLKDVVRVKAYIteaaFF 83  Magnetospirillum...
AAV94309     57 ISSGGPFEAKiGYCRAVVAGgFVHVAGTVGqg-------edVVAQCRSALEVIGAALKEAGAGFADVVRVTYYLpdaaEF 129 Silicibacter pom...
NP_934358     7 VKTGSKLEEIaSYSRVVAVDnWIFVSNTAGrnpetgempkdVFEQTEQVFTNIEVALASVDASLKDVITSKVFIqnpdNV 86  Vibrio vulnificu...
ZP_01113987   8 YSLDSTFEKLlNYSRVVVDDeWVFVSGCSGfdysdmsiadtMTEQVEQTFKNIQWCLSQAGAVFEDVVRIRVIVadrdHY 87  Reinekea sp. MED297

Feature 1          #  #   #   #########          # # # 
AAF09626    113 EQVGRAHGEVFGaiRPAATMVQVaalidprHLVEIEAEA 151 Deinococcus radiodurans R1
YP_997696    94 LAVSQVLRRRLGhnRPANTTLCCala-vegAKVELEVSA 131 Verminephrobacter eiseniae EF01-2
NP_436434    85 ADVTAVLGEVFRdiRPTSTMLICeip-apgAKVEIEITA 122 Sinorhizobium meliloti 1021
ZP_01550267  84 LDIAKHLGTVFQdpRPTNTTVTCgfv-ndeIKVEIEVTA 121 Labrenzia aggregata IAM 12614
ZP_01014481  86 EACWPVLSKAFAtaRPAATMIEArlm-npeMKIEIEAVA 123 Rhodobacterales bacterium HTCC2654
ZP_02190826  86 ERIKPIIKRHCDaaRPANTTVLAelv-epyMRVEIEVTA 123 alpha proteobacterium BAL199
ZP_00053229  84 EQIAPVLGKAFKgiRPANTTIVCglv-dprMKVEIEVTA 121 Magnetospirillum magnetotacticum MS-1
AAV94309    130 EPCWPILAETFGanPPAATMIECgli-dpkYRIEIEVTA 167 Silicibacter pomeroyi DSS-3
NP_934358    87 PAVMEFVGTKFRgvNPTTTVTCPplg-stiYEVEIEVTA 124 Vibrio vulnificus YJ016
ZP_01113987  88 NEAATVIGRYCAqaKPANTTWFAelp-dprIKIEIEVTA 125 Reinekea sp. MED297

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