Conserved Protein Domain Family
bHLH_scINO4_like
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cd11403: bHLH_scINO4_like 
basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar proteins
INO4 is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast. INO4 dimerizes with INO2 and binds to an UAS DNA element to control expression of the genes whose expression is inositol-responsive.
Links
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Statistics
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PSSM-Id: 381409
Aligned: 6 rows
Threshold Bit Score: 96.3793
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Homo sapiens Max (1NLW)-Mad basic region binds the DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       # ### ### ##   #                                  ##                          
124504     45 QIRINHVSSEKKRRELERAIFDELVAVVPDlqpq---------------esrSELIIYLKSLSYLSWLYERNEKLRKQII 109 Saccharomyces cere...
OEJ85391   48 VKKKNHISSEHRRREMIKQKHDSLIKLVPAlskdp-------------eqvkGELIIYPKTYEYLVALYEENLRLRKLLA 114 Hanseniaspora osmo...
NP_984781  42 QKRENHVTSEQRRREILREYYDELVRLVPDlqes---------------enrSEWQIYMKTRNYLCWLYKRNAQLRRQLK 106 Eremothecium gossy...
ELQ36491   41 EKRENHTRSEHKRRETIRGHFERICAIVPEldss---------------msrSEAHVIVMSHTYIKELKSRRRALVEFLR 105 Magnaporthe oryzae...
PRQ71629  393 QKKANHIASEQKRRAAIRAGYDGLCEVVPAlsaavaefeervrkidgragpkSEAVVLSKTVEHLRTLLTTRATFLSQLS 472 Rhodotorula torulo...
POE66098   13 QKKANHIDSERKRREAIREGFDRLSEIVPGmgg----------------qgrSEAVVLQHTVQYLMEEQMKREKLKSVAM 76  Quercus suber

Feature 1           
124504    110 AKHEAK 115 Saccharomyces cerevisiae S288c
OEJ85391  115 NSLVSH 120 Hanseniaspora osmophila
NP_984781 107 LTNVKY 112 Eremothecium gossypii ATCC 10895
ELQ36491  106 SKGIEI 111 Magnaporthe oryzae Y34
PRQ71629  473 SLHAVA 478 Rhodotorula toruloides
POE66098   77 SKGMTE 82  Quercus suber

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