2QHT,2QHS,1W66


Conserved Protein Domain Family
LipB
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cd16444: LipB 
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lipoyl/octanoyl transferase
Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.
Links
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Statistics
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PSSM-Id: 319743
Aligned: 93 rows
Threshold Bit Score: 191.165
Created: 4-Apr-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2QHS: Thermus thermophilus lipoate-protein ligase B with bound octanoic acid, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
2QHT_A      4 LVEDLGLvpYGEAWAYQKRVHrevva--------------------------------------gnrpPTLLLLEHPRVI 45  Thermus thermophil...
2QHS_A     24 LVEDLGLvpYGEAWAYQKRVHrevva--------------------------------------gnrpPTLLLLEHPRVI 65  Thermus thermophil...
O19898      3 LIIRYGLlnFETSWVHQKTMVfiqir-------------------------------------krqkkKLSIYLKHPQVY 45  Cyanidium caldarium
A2C0K7     32 LFEPKNIvpFETALGWQKNFLknlie-------------------------------------epfspQAVWLLEHFSCF 74  Prochlorococcus ma...
A9BE20     32 IFEPSELidFRVAWDWQKQRQkllfe-------------------------------------kpgssQAVWLLEHSECY 74  Prochlorococcus ma...
Q7V2R8      8 IKQPDKIsfFYDVYKLQKEYQdslis-------------------------------------gksnmNFIWLGEHQLCY 50  Prochlorococcus ma...
Q6KZK7     32 IIFETPMe-YKPVLYFQRKLVdlrnn--------------------------------------dkidDTFIFLEHNDVY 72  Picrophilus torridus
Q04TD5      4 IRFRKKIp-YLRYLEMQEKLRkf-------------------------------------------rrECILFLEHAPII 39  Leptospira borgpet...
Q6L1M2      9 YIDLKRFd-YKKCLDIQYRLVsmrkn--------------------------------------dligNTIIFVEHDPVY 49  Picrophilus torridus
O13476     51 HLQFVKEipFETGIDIQEKFVrahldikqlqskikremtnlqkehnaeiqlnfheqmildninqmkpnPIVLTFQFEPTY 130 Kluyveromyces lact...

Feature 1                                           # #### #       #                          
2QHT_A     46 TLGrkatgenllfpes---------wyrengfelywvERGGDVTYHGPGQLVGYPIFPvgre----vrrfLRQIEEAIVR 112 Thermus thermophil...
2QHS_A     66 TLGrkatgenllfpes---------wyrengfelywvERGGDVTYHGPGQLVGYPIFPvgre----vrrfLRQIEEAIVR 132 Thermus thermophil...
O19898     46 TLGhrankeyisfc------------snntlvnlhrvDRGGEVTYHDYGQVIIYNITHlqkinr-nvniyIANLEQLGKR 112 Cyanidium caldarium
A2C0K7     75 TMGrgsdkknllfe------------ennsplpvfsiERGGEVTHHMPGQIVGYLVLNlslhkk-dlawyLRELEQVLID 141 Prochlorococcus ma...
A9BE20     75 TLGrgatednllfn------------lsnspwdvyriDRGGEVTHHMPGQLVVYLVLDlrrykt-dlnwyLRQLELVLLD 141 Prochlorococcus ma...
Q7V2R8     51 TVGrgsnmdnllf--------------sadeqdvfkiDRGGEVTCHMPGQLVTYLVLDlsnlnk-dlnwyLRKIEKIIIK 115 Prochlorococcus ma...
Q6KZK7     73 TAGvhyrgn----------------------ddiirvERGGYETYHGPGQLVVYFIINlrerkm-naldlIKKIQNSVVN 129 Picrophilus torridus
Q04TD5     40 TGGinynpenlllgke---------flesqgiqvhfvQRGGDFTAHEPGQLVIYPHVDlkkrnl-pirfyLENLLQSVID 109 Leptospira borgpet...
Q6L1M2     50 TIGrkadprny------------------snvnvirtDRGGDITYHGPGQLVSYFIFDvringkkevktfLNNIENVYIN 111 Picrophilus torridus
O13476    131 TGGkrvkkqitdeqiaryegfipskqkynkkpkfvqaERGGQVTFHGPGQIVAYIILDlktfqnlpakclVSTIDNAAMN 210 Kluyveromyces lact...

Feature 1                                         #  ###          ###                         
2QHT_A    113 VAAGYgi--------sAYPTPg-YAGVWVg----EDKLCAIGVAVkegvSFHGFALNVnt-dLNDFTVIVPCGLKGKGVT 178 Thermus thermophil...
2QHS_A    133 VAAGYgi--------sAYPTPg-YAGVWVg----EDKLCAIGVAVkegvSFHGFALNVnt-dLNDFTVIVPCGLKGKGVT 198 Thermus thermophil...
O19898    113 ILLLYkt--------kSTKKEk-FPGIWIq----QKKIVALGIKIiqrtTFHGLSINFsc-sKRNYELILACGIKDGISV 178 Cyanidium caldarium
A2C0K7    142 VLDLLgi--------eGKRVDg-LTGVWCe----DKKVGSIGIGCkrwvTQHGFSLNVdc-dLIGFEKIIPCGLDKVKVG 207 Prochlorococcus ma...
A9BE20    142 TLKDLgi--------vGKRIDg-ITGVWIn----DFKVASIGVGCrrwiTQHGLSINVdc-dLRGFERIIPCGLTGSKVG 207 Prochlorococcus ma...
Q7V2R8    116 TLRSFni--------nCSTKDg-FTGVWIg----ERKIASIGIGCkrwvTIHGFSINVnc-kLENFNKIVPCGIKGCQMV 181 Prochlorococcus ma...
Q6KZK7    130 TLKYYni-------esYPMLNe-KTGVWHe----DRKICSIGIAIrgfsTFHGMALNVnt-dLSKFNRIMPCNFSPDIMT 196 Picrophilus torridus
Q04TD5    110 SARTTwg-------lnLITDSd-SPGLYLes-nsSKKICSIGVNFksffTSHGVAFNLnn-dFTAFRCINPCGRNWTDMT 179 Leptospira borgpet...
Q6L1M2    112 LLKNLgy--------sASTGD--EPGIWIekngkLKKVASIGMAIddyvSYHGVALNInkevLNGFIKINPCGLPPAVMD 181 Picrophilus torridus
O13476    211 ALKVVpkfqgsdeplnLITQKtnDTGVWVs---nQEKIASIGIHVrrsvTSHGICINVdp-dLSYMNSFTMCGLSEKKAT 286 Kluyveromyces lact...

Feature 1                                  
2QHT_A    179 SLekll--grkvPMEEAKARVVAAFAEVF 205 Thermus thermophilus HB8
2QHS_A    199 SLekll--grkvPMEEAKARVVAAFAEVF 225 Thermus thermophilus HB8
O19898    179 NFneihk-knsqNQFYWKYKIVLLIVDIL 206 Cyanidium caldarium
A2C0K7    208 KLsdwi---pgiKVCDVTPLLRESVKRRF 233 Prochlorococcus marinus
A9BE20    208 KLssli---pdlKTVDVKPFIKKSLTERF 233 Prochlorococcus marinus
Q7V2R8    182 NMsdyn---knvDIKEVKKIVKKIIHEEF 207 Prochlorococcus marinus
Q6KZK7    197 SMeris--grpfNINSVRERLIQSIEKEF 223 Picrophilus torridus
Q04TD5    180 SVeklgldsgfaKRNQFISFMKANLNSFL 208 Leptospira borgpetersenii serovar Hardjo-bovis str. JB197
Q6L1M2    182 YIdikrd-daidLIIREIEKIYGKFNKIE 209 Picrophilus torridus
O13476    287 SIreqvp-dsstSVNDVAVAFVNQLAKLL 314 Kluyveromyces lactis NRRL Y-1140

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