1US7


Conserved Protein Domain Family
CDC37_M

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smart01070: CDC37_M 
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Cdc37 Hsp90 binding domain
Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.
Statistics
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PSSM-Id: 215010
Aligned: 23 rows
Threshold Bit Score: 139.822
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1US7_B        20 PE-----K-------Te--EDSEEVReqKHKTFVEKYEKQIKHFGMLr--RWDDSQKYLSDNVHLVC-EETANYLVIWCI 82  human
NP_986513    202 KPdqaalP-------Ds--LKLVPTDfiDFKDDPMKLAPETEQFGSVpvgNYKASEAYLLDHVSILS-EQQKDALMMQAF 271 Ashbya gossypii...
XP_453822    203 TN-----Q-------Va--LPKPKIQpiDYKDDILKIAPETEKFGSIqpgNYAEAEKFLLEHPQILS-EQQKDALMMSAF 267 Kluyveromyces l...
XP_445727    234 EA-----Q-------Es--QQAVQTQstTDDEDMLHLFPETEQFSKIptgDYKKSASFLMENYQIIT-EQQKDALMMKAF 298 Candida glabrat...
XP_001384434 245 SQ-----E-------Ks--LPEKSEKeiLDELTVL---PATESFAKIsssDLKKSGEFLLKHTSICT-EHQKDALIMTAF 306 Pichia stipitis...
XP_456605    231 NN-----A-------SnvsPASKEPKsdKDVLDELTLNPSTAEFGKIsstNIDESANYLIRHTHICN-EQQKDALIMTAF 297 Debaryomyces ha...
EGO58182     230 LP-----A-------Ps--TTTNDDDddAEIE----ASPAAKQFASIkadDYRESLAFLTKHPEILT-EKETDGLLVLAF 290 Neurospora tetr...
XP_751825    215 LN-----PravqddaPk--ADDNEQVdpDD----VKASDLAKKFARInrnDYRALLQFISEHPEIVA-EKETDGLLVEAF 282 Aspergillus fum...
XP_570423    252 SA-----A-------Pv--APATEDt--DDEEDFGPLSPAGRAFAQIplgDFEKAYDFIKNDSSVLS-SSTHDSLLAEAF 314 Cryptococcus ne...
NP_595752    226 GN-----A-------Pk--NPVNENEseDEEG--LSLSEDGKKFANIdfgDYSSSEEFLKEHLNILAdEEESDAILLEAF 289 Schizosaccharom...
1US7_B        83 DLEVEEKCALMEQVAHQTIVMQFILE------L------A--KSLKVDPRACFRQFFTKIKt------ADRQYMEGFNDE 142 human
NP_986513    272 EYQLAGDEKKAYQVIHQSELMSYIREiyamkkI------P--HLNAEELKEVIRVFFQKVFyntnnkmGKSSFLESVQSK 343 Ashbya gossypii...
XP_453822    268 EHEMSGNTQRAYQVIHQSELLSYLLEiyamkkL------P--DFNVSQMKEVIEMFFERLFsprsnpmAKKSFLESVQTK 339 Kluyveromyces l...
XP_445727    299 ESQLKHDEKRTYQILHQAEILAFIDS------IynvqrsP--TLDVQRLKNSIEVFFKRVFlesrieaAKAQFLDSVNTK 370 Candida glabrat...
XP_001384434 307 DYQLEGNSAAAKQIIHQSLLLQYIAQ------La----gP--QPAQASVINAIKLFISKVSea---spARAGFMEDVQNT 371 Pichia stipitis...
XP_456605    298 DHQLQGDTDAARQVIHQSLLLQYVAQ------L------AgvKPNKDSIIKAVKLFCSKINdks--spARMGFSQDVTNT 363 Debaryomyces ha...
EGO58182     291 DAQLQNRDDYARNCVHQALLLQYCRA------L------G---------RDGVALFFKRIttq--ghqAQEVFFKDVQDT 347 Neurospora tetr...
XP_751825    283 NSQMEGKEEYARQCVHQGLLLQYCRS------L------G---------RDGISLFFKRIttkd-hqaA-TLFRNDVNET 339 Aspergillus fum...
XP_570423    315 DAERRGDKSLAMRCVHQSLLVNYCRQ------L------G--K-------DGVGLFFQKMIqkn--pkSITMFNEDFQRT 371 Cryptococcus ne...
NP_595752    290 NAELEGKPSLAKQYVHQALLISYCRQ------L------G---------PNGLSIFFQKIKdpn--hqSQRLFLEDVHNT 346 Schizosaccharom...
1US7_B       143 LEAFKERVRGRaklrIEKAM 162 human
NP_986513    344 FKHVTERCKVLaneqADtte 363 Ashbya gossypii ATCC 10895
XP_453822    340 YEHVKTRSKAMqeesDGEge 359 Kluyveromyces lactis NRRL Y-1140
XP_445727    371 FEHVKKRCVILeeeeRNNEG 390 Candida glabrata CBS 138
XP_001384434 372 FNHIKNRCEII----REEQA 387 Pichia stipitis CBS 6054
XP_456605    364 FNHIKSRCEIIkqeqGTENN 383 Debaryomyces hansenii CBS767
EGO58182     348 FYKIKNRAREInlqrAKEEA 367 Neurospora tetrasperma FGSC 2508
XP_751825    340 YNKIKTRAAELakdsSaand 359 Aspergillus fumigatus Af293
XP_570423    372 YNRIATRTREIlaeeAaagp 391 Cryptococcus neoformans var. neoformans JEC21
NP_595752    347 YVRIHERSAAIskeqAEsge 366 Schizosaccharomyces pombe 972h-
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