Conserved Protein Domain Family
EAL

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COG2200: EAL 
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms]
Statistics
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PSSM-Id: 441802
Aligned: 895 rows
Threshold Bit Score: 110.259
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_015170962  38 VTPQTFGEVIARELARCPELPGVLITENQGFRGMISRQRFMERMSRPYSLELFLKRPIQIFLEAAENCQAPLLLSAASPI 117
WP_011747215     --------------------------------------------------------------------------------    
WP_084812408   1 -----------------------------------------------------------------MLRLSGGPRTSEHTG 15 
WP_076628800     --------------------------------------------------------------------------------    
WP_087037222  63 WSLMQLQLEMGRFLDAVRLRHAAAISQDDFMLRYDILWSRTPLLLSSQFKSGLGERPELGLLIRQIDARIHELEPTVEGL 142
WP_124690473     --------------------------------------------------------------------------------    
WP_025359229 165 ALTVGFTQGTRQRVLAEQTAIHQGRAEALTKAQRHRSAQRGQFLACYGEFGIAMGLLDAAGRVLVANPALRELLRRTDAQ 244
WP_081507120     --------------------------------------------------------------------------------    
WP_084208675  49 VLDSEHEKRYDDLTRLVADIFDVPICLVSLVDENRQWFKAHCGIDARETGRDLAFCAHALHEERYLVVNDASKDERFHDN 128
WP_069040412  78 LRRIAVRDAQQRIVASREAPARLAGGAPQWFVDLLPLASGAQTADIMSGWRIAGSVLVEPHPHWAYLQLWTVAQTLLVWM 157
WP_015170962 118 EDAVQKALQRPTAHLYEPIVIVSEDHQLRLLDFQALLIAQSQLLAAQRAELMQQAQEISLLNQCLSWQASHDPLTGLLNR 197
WP_011747215     --------------------------------------------------------------------------------    
WP_084812408  16 HMARIRTDHEDRGRLGVLARRIRMALGRVEVLALFPLIAISATALGFDDLALVTAIGLSALLAIGGVGARAAQPVATSDR 95 
WP_076628800   1 ---MQFRAPEKLNNLRQGAAAVLTGPQMLAFVPAIMLAAYWLGGEVALTTMAIALPLAWLAFGGIEDLIRQRMARNLQPG 77 
WP_087037222 143 QPHSPDYLIILTALSPYLEPLSRTVSALMHDNVRFYAEYDLAYRQLGKQLYRSIEGFFVALLLLLVLLFRELHRYWRLQQ 222
WP_124690473     --------------------------------------------------------------------------------    
WP_025359229 245 LIGTALSELVDQVDAGHTASACETVRAHCPHVYLTVRLRAAEVHLALHWSEDGTSEGAVHLVVDHEPVTRLSPDWLRQAA 324
WP_081507120   1 ------------MVTAGQERIAGIAARLRARHWPQSLALIAAAGLATHWFGLAALLLALPLTLLALALSDRRQTPPLTDE 68 
WP_084208675 129 PLVTGPPYLRFYAGALLRDSSGLPLGTLCLIDHTPRELSAPQLERLGRCAMLVENELIQRDSLLTERTRATLQASIDPIT 208
WP_069040412 158 GGGLAVAGALGLAALRWGLRPLRRVQRSAVAAASRKFMPIDEARVPTELQPLVGAFNRMLGALALALDAESTRAERFRDQ 237
WP_015170962 198 REFEQCLEQAIADVSGDASIADRPPILAYLDLDCFKIVNDTCGHAAGDELLRQVANLFKGHLRTSDLLARLGGDEFGILL 277
WP_011747215   1 -----MAYGIAAAASRLARLVRGEGATRGKVRLALVLRVENVEVLRDSIGPALLEQMLDRLLLRLVAELRLLPQGCSRGC 75 
WP_084812408  96 PTANGRGALVAMLDRVADLPGRDTACILLQIDDWALLHDRWGHDTREDLAARVEDRLQTALRNGDLLTRLGDARFGIVLS 175
WP_076628800  78 VVSQDTFGDKIDTIRQDAPAADKNSAMFSIELDEHATLADRFEPAAIDRILKAVADRLVTTMRDNDTLCQTGDFRFSLCL 157
WP_087037222 223 QDPLTGLPNRLALQRHISTLIEQDQPFSLTLLELKDLNSHYQHFGFKVIDQLLQVCCERLQGSLLGYEYLAQPSEGKIVV 302
WP_124690473     --------------------------------------------------------------------------------    
WP_025359229 325 GPDPVTGLPGPQYFAHRLEQALRGASQQEPISLCLVRLRAWTGVRRAHGAAAAEAVLRAIVPRLIAACDAAHLLARIEPD 404
WP_081507120  69 AARSAPLRAAIADSLSNTRQGGTRTACLLLQIDEFETLTHRHGLAAADRVILQSLERLARMLRPADQLFDLGDGRLGVLL 148
WP_084208675 209 GYSTRRRYLQTFAHWMENRGSESYQAIMLKVSEAEHWRHHQGEVFLQEVMQSLSSQINESFDDEDVIKGRLCSDTLIILL 288
WP_069040412 238 ALVDELTGLANRRGFRAALEARIEAGQRSGWLALLRIDGLEDLNNRYGRQTVDDLLTESAQYIRDAAKGGLCGRIEGACF 317
WP_015170962 278 QQCSLEEARQVAERLRSSIAALRFCWQGRVFAIGVSIGLTAVTKGCGSSAALLNTADAACYAAKNRGRNRIQVYEMGDRE 357
WP_011747215  76 GEILGLLAFGGCQAVPGLLARLQAICADGIGLPGLRIRPLVNAAIVGDETGRQGAAALYAHGRLALQGSGPLSPVGQVRY 155
WP_084812408 176 PLPSARLGLRDTITTRLADAVADPLPMRGTALRLTASIGHSAMIKQGVDPADTTFKAAEAALGEATANGPGTIRAYAPGM 255
WP_076628800 158 GQVQHLDLESCIQLSGRYQQAIEEPIAIDGTTIYVSVSVGFCLLNRAPGGTGRDWLNGSLAALTEAQRRGPSSVRAYSTE 237
WP_087037222 303 VGKGVVELADIRAQLSRFSHVLNEKASVAGYDFYMEPLMGVVLYPFDADNLVDLQARCELALELCKQQQKNYVFFDPSLL 382
WP_124690473     --------------------------------------------------------------------------------    
WP_025359229 405 TFALLLTGRDAWTRGMDLAARCRDWVGAAVHHGDRLLLLDPAVALATSTGQVGGHELVRRGLGRLEQPGPVLAPVPRPAP 484
WP_081507120 149 APKPGLTLGPLLALAERLRAALAEPIALDATTLHISASLGLCLDAQAPARTATALYDACHTALHEAQRHGPAAIRAYGRG 228
WP_084208675 289 PQRQSVSGMRWQRFITQPWLMHLSSALRPKLLVATATFTPEGATAHELVELLEEELASAAHWAPCQQNLQVADLSSNVTL 368
WP_069040412 318 ALLVDAAEAPARQLLGALRARLNGLARAAGTDDPDAWRGGAADCGSDGDAAHWLAAADRALHLWLPADTQEFPLAHAQDI 397
WP_015170962 358 l-LQKQG--------Q-V--H-WV-A--QIT---D----A-L----E--------RDRFKLYYQAI-V-PVATLAdtsdr 399
WP_011747215 156 -----------------------------VEtgrEaappA-L----Al--------DRVGLLFQPQ-L-CCDTGQ----- 186
WP_084812408 256 g-RARAL--------Q-S--S-LS-E--EVE---A----A-I----H--------DGAITAWFQPQ-I-HARTGT----- 292
WP_076628800 238 lhSRLKN--------R-A--H-LR-D--EVA---A----A-L----E--------QGHIQPWFQPQ-I-STDTGK----- 275
WP_087037222 383 --KEMSR--------R-Q--Q-LA-K--DLP---A----A-I----T--------SNSLTLQLQPL-L-TWPAQQ----- 418
WP_124690473   1 -mRPLQElsvayaavRtLi-EkLS-SqpDLH--------AsLrlapDgtvlgrfyEfELASGFQPV-V-RIDTRT----- 62 
WP_025359229 485 -----AE--------R----D-LL-V--ELP---A----A-F----R--------REEVELAYLPT-V-RLADNT----- 516
WP_081507120 229 --MAAPTp------pP-R--A-LA-Q--EVT---T----A-L----Q--------EGRLITWFQPQ-I-CTDTGQ----- 266
WP_084208675 369 ---------------A-I--A-LG-D--RFA---R----A-L----R--------DNELSLHAQPI-L-DVRTRK----- 399
WP_069040412 398 ---------------EsagaA-VRgT---VR---D----L-I----G--------QGRIAFASQATrVlDA-GGA----- 432
WP_015170962 400 eisqclaaaTTH-YEVLLR-LPDE-A-G-H-LVPPSAFLPAAERYGMMQAIDRWV-LTTLCR--QHQDRCQRgltteTGt 470
WP_011747215 187 ---------VAA-LRVLPRiWl---D-G-GdSCGLAEL-ELRLDDGTLGQVVADV-LRQAFA--GLRGWDRl-----GRp 242
WP_084812408 293 ---------LAG-METLAR-WQHP-N-H-G-VLGPKEFFSAVEASGHMPLLGQTL-LHQALK--ALQDWDAM-----SAh 349
WP_076628800 276 ---------VAG-FEALAR-WIHP-D-R-G-AISPAEFLPAIEDAGLLERLAEIM-IYHSFT--ALKAWDSA-----GLr 332
WP_087037222 419 ---------CVG-LQVLTS-WHHP-S-F-G-VIAPAELQRMTEQYQCAEGVMLWS-LQAMCS--QLRVWQRH-----AYq 475
WP_124690473  63 ---------VAG-YDAYAR-SHAT-D-G-D-VISPWGLFSRAADDATLVRLDRLCrLVHTLN--YFSKA-D------ATh 118
WP_025359229 517 ---------LVA-AEATLR-WRHP-T-R-G-LVPIDHLIQRAEDIGLRLPLTALFr--TACA--HARGWHEEl----GRs 573
WP_081507120 267 ---------ITG-FEALAR-WQHP-T-A-G-LIAPAEFLPLLAASGRMEVLGDAM-LANALR--ALQTWDHL-----GLd 323
WP_084208675 400 ---------VCG-MEMLL--RWQV-Q-G-R-WVTANQMLRMAERAGIGEELDTWV-LRQTCA--MVSRWQSQ-----RSt 455
WP_069040412 433 ----------AGaLHVELR--A-AlDaGdR-FIRAAEYMTYAGEARVSAALDSAC-LMRALEhaQVR--RD--------- 486
WP_015170962 471 -S-W------L---------------------YSVNLSGASL--NDDQFVEFVRHQLARFDIAPSLLCFEITE-TVAIS- 517
WP_011747215 243 vP-L----------------------------LSLPLSDRVL--GDASIADTILWELDRNDLAPQRLEIEVSE-PIGRS- 289
WP_084812408 350 -I-P------L---------------------ITINFSATEL--RDQNLAATLASEVARYGLAPERVVVEISE-TVATQv 397
WP_076628800 333 -V-P------H---------------------VGVNFSGSEL--NNPKLVDKVRWELDRFDLTPDRLAVEILE-TVVTD- 379
WP_087037222 476 -DyLpnslpnSlpnslpnslpnsqqdpqpplfISVTLPA-PL--FRlGIEVSLLAVLQQYSITPASLVLEINE-EIVAT- 549
WP_124690473 119 -P------------------------------LYLRVHGRLLaaITHDHGQAFRRMVEALGVPPARIVLQLPG-EAa-Q- 164
WP_025359229 574 -A-P------H---------------------LIVNVPAWLA--RTDRLVGQVTGVLSKTGLPPASVHLGLTE-AGLLC- 620
WP_081507120 324 -I-P------C---------------------VGLNLSPEEL--RNPTLPEKFAWELDRCDLPAHRLVIEVLE-TVVAI- 370
WP_084208675 456 eS-Lgv-------------------------pVSLNLSAKRL--IDSEYAETLRRILRLYRLKGEHLRLDLTGcERFAE- 506
WP_069040412 487 -G-L------A---------------------TVVNVSAAAL--IDPDILRWVGGy--RHDARRAGFILEFSE-VALLG- 531
WP_015170962 518 NLTR-AVKLIDQLRAIGCYFALDDFGSGMS-SFGYLKNLPVDYLKIDGNFIK-S-LVSSPVDVAMVEAINRIGHLMGIKT 593
WP_011747215 290 GgRMpVTASLRRLRAAGCAIALGDFGTGSA-GLDDLRRFGIGRVRIGRGFVS-G-CDRHADQQRMILAILALADHLGLAT 366
WP_084812408 398 EDDA-IVATLQAMRHAGHRLDLDGFGLGAA-SLPTLQRFAVSRVKIDRSFVL-D-IDLDHGKRQSVTAIVAMAKAMGIET 473
WP_076628800 380 TTADtITRNINALAKLGCRIDLDDFGTGHA-SISSIRRFGVSRIKIDRSFVM-K-ADRDPEQQRMISAVLTMAERMNIET 456
WP_087037222 550 DMPT-ANLILARMRAVGIRIMLTEFGSGSA-PLGPLSQLPLDWLKLNATQCT-G-IEHQGDARRQLTALLAMAEVLTVPV 625
WP_124690473 165 DVLL-AGMILGNYKKAGFLSGVHANNVGEAqSLLHLH--APEVIKLDLRTVA-D-----P--EHELPPLLEAAAGLSCQV 233
WP_025359229 621 EHGG-IRPHLPLLAGHGLALRLNNFGLTFA-RFDQLPELTLREIAIPSPRGPgDgASAAQCRQTVTEHLVRLGRQLSHAI 698
WP_081507120 371 SADDvITRNIAALARMGCPIDLDDYGTGHA-SLATIRRFAVHRLKIDRSYVT-A-IDRDPDQQRMVGAILSMADRLGLAT 447
WP_084208675 507 TPEA-LIAAMTSLTRDGVSFCIDRFGRENA-NLRLLSRMPAVAVKLHPRFMV-P-QQHEPDQTRLIKAWTCAMKTLGLVP 582
WP_069040412 532 DPDA-AEAFAQLAQSRGLAIGIKHFGLHAN-ALSLLRRLRPQHVKFSVTLTR-E-ALLNPDSGAYVSSLTGIASALSILP 607
WP_015170962 594 VAEFVETESILAKVMELGID---------------------YAQGYKIAV---PLPAP-LpLA-AG--S 634
WP_011747215 367 LADGVATQEENAFLAQIGFN---------------------AVQGPAVVP---PLEAAaV--DgFLldR 409
WP_084812408 474 IANGVETQTEQDALLALGCD---------------------YLQGFGVAR---PMGLDnV-AD-WA--R 514
WP_076628800 457 LAEGVETVGEHALLAQLGCD---------------------YVQGFGIAR---PMPFEkT-LD-WV--R 497
WP_087037222 626 VCCGVDHVSELTALESLVLDssasarpertrpesnnhnaalLVQGDAVGE---PLlVTeVg-E-WL--K 687
WP_124690473 234 VFKRVEDEASLARLAALGAQ---------------------YAQGYLFGA---PSAS--L-AQp----S 271
WP_025359229 699 TLQGVASATDVALAHAIGAD---------------------YVQGPSLGE---PCPAEeI-AH-RVlhp 741
WP_081507120 448 LAEGVETAGELAMLAQLGCA---------------------HVQGFGIAR---PMPLAaT-PD-WI--A 488
WP_084208675 583 IAVGSKRVQQLSELESLGFD---------------------QVQSDAFGQ---PALPEdSyAQ-WL--A 624
WP_069040412 608 VAVAVEHVETLAALHALGFR---------------------GVQGEAVAAeilP-----V--------R 642
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