6BGI


Conserved Protein Domain Family
Anoct_dimer

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pfam16178: Anoct_dimer 
dimerization domain of Ca+-activated chloride-channel, anoctamin
This family appears to be the cytoplasmic domain of the calcium-activated chloride-channel, anoctamin, protein. It is responsible for creating the homodimeric architecture of the chloride-channel proteins.
Statistics
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PSSM-Id: 465044
Aligned: 113 rows
Threshold Bit Score: 173.516
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6BGI_A         54 YFRDGKRKVDYILVYHHKR--------------AsgsrtlarrglqndmvlgtrsvrqdqplpgkgspvdagspevPMDY 119 
XP_002117000   47 LEEPTERPIDYVLVYKDCD--------------D------------------------------------------PSNP 70  
EDO48048       16 FFNKGGHKVDYVLVYETCQ------------------------------------------------------------- 34  
XP_015217201   50 VFSDGVTRIDFVLVWEEEVrenpkatepdgkaaG---------------------------------------------T 84  
XP_009289708   41 VFSDGVTTIDFVLVWEESGsplksad-gdelsfS---------------------------------------------S 74  
XP_014967030  104 GSPAKPRIADFVLVWEEDLkldw-------qqnS------------------------------------------ASRD 134 
Q14AT5         47 VGSSAKPPIDFVLVWEEDLrnqe-------nptK---------------------------------------------D 74   house mouse
XP_004743842   61 MGSPSKPRVDFVLVWEEDLklgeq----qdstiR---------------------------------------------D 91  
XP_016280183   33 weeiGSKKED----KGKRKn-------------K------------------------------------------KAKR 53   gray short-ta...
XP_007236829   50 fvlvwdEPVTPLKASEPED----------------------------------------------------------KTS 71   Mexican tetra
6BGI_A        120 HEDDkr------------frREEYEGNLLEAGLELEN--D-EDT-K--I-HGVGFVKIHAPWHVLCREAEFLKLKMPTKK 180 
XP_002117000   71 REVEra------------eqRQIFEERLQEDGLQVTY--E-KV-------LHLNFVKIYCPFKRMGKEAEKVNYEMDLA- 127 
EDO48048       35 -EREdkdpkfaakmadferkRDAFEAALSEQGLVIER--E-SITsPqnDkVKRHFVKLHVPWRTLSSKAEELMLKAPLQ- 109 
XP_015217201   85 SQDMhq------------kyRKRFLSRLQKVGIQMDK--K-VEIrEk---TRITYVLLNAPWSVLCYYAEEISLRVPLQV 146 
XP_009289708   75 SRDThr------------kwRTEFLSKLQEAGLHQEM--K-EVVqGk---TKTTYVLLSAPWNVLCYYAEEISLRVPLQV 136 
XP_014967030  135 RTDThr------------twRETFLDNLRAAGLHVDR--H-DVQdGn---TTVHYTLLSASWAVLCYYAEDLRLKLPLQe 196 
Q14AT5         75 KTDThe------------vwRETFLENLCLAGLKIDQ--H-DVQdEa---AAVHYILLRAPWAVLCYYAEDLRLKLPLQE 136  house mouse
XP_004743842   92 KTDTha------------awRETFLENLRAAGLCVDQ--R-TMQdGp---GTVHYILLSAPWAVLCYYAEDLRLKLPLQE 153 
XP_016280183   54 KEYAhr------------iwRWKFLEQLQATGIHMEQhiV-KSRk-----RSIHYVLLGAPWTVLCHHAEILRIKMPLQa 115  gray short-ta...
XP_007236829   72 TQAThr------------kwREEFLSKLQTAGLQQEQ--KeVVQ-S--K-TKTTYVLLSAPWNILCYYAEEISLRVPLQV 133  Mexican tetra
6BGI_A        181 vyhisETRG-LLKTINSVLQ-----KI-TDPIQPKVAEHr-----P---QTTKR-LSYPFSREKQHLFDL-TDRDSFFDS 243 
XP_002117000  128 --------------GIQLKKydfcwLInSLPLQINEEPKgcigrlFrtdEQVDY-VSAPFVWNKRQAFEGvEKSRSFFRN 192 
EDO48048      110 -----ENDIdLKTTGEKIFD----------PFRIKDSSI----------PEKPKcFMAYFKERKVDKYMGkAEPEKMFTA 164 
XP_015217201  147 ----------VPHKMSNWSE-----KVlQKLGIANVMQQ------DvpnPPPDF-YTCQFRNNKLERFLGsDNQDTFFKN 204 
XP_009289708  137 ----------VTTPISNWSE-----TIlEKLHIPNIMAQ------DvpnYPPDY-YTCPFRTTKLERFLGhENKDTFFKT 194 
XP_014967030  197 ----------LPNQASNWSA-----ELlAWLGIPNVLLE------VvpdVPPEY-YSCQFRVNKLPRFLGsDNQDTFFTS 254 
Q14AT5        137 ----------LPNQASNWSA-----TLlEWLGIPNILLE------HvpdTPPEY-YSCQFKASKLQWFLGsDNQDTFFTS 194  house mouse
XP_004743842  154 ----------LPNQASNWSA-----GLlAWLGIPNILQE------DvpgVPPEY-YSCQFKLSKLSRFLGsDNQDTFFTS 211 
XP_016280183  116 ----------MPSQASNWSD-----NLmRKLGIWNPLYQ------EvpqTPQDY-YTYPFQESELSRFLGsENPQTFFAS 173  gray short-ta...
XP_007236829  134 ----------ETNEDSNWSE-----KIlHKLHIPNILAQ------QvpnPPPDY-YTCQFHTKKLERFLDhENKDTFFKT 191  Mexican tetra
6BGI_A        244 KTRSTIVYEILKRTTC-----TKAKYSM-GITSLLANGVYSAAYPLHDGDYE--G---DNVEFNDRKLLYEEWASYGVFY 312 
XP_002117000  193 SVRSLLVHNILINTDIrqgadTEDKINCrGLLYLIMQKAYSDAFVLHNPFVNgkKv-aSKIGNTEREELYRSWGS---CF 268 
EDO48048      165 LDRHYVVQRICYATRF-----AEGPKGV-GLKQLVYEGAYCANYPLHDGDDDviGe--SSYPSNDRQRLKKDWSSMKRIF 236 
XP_015217201  205 TQRHQILYEILARMPYg----AMKRGEV-GIDRLVSENIFTAAYPLHDGSFEppPgqvHPETLSLRQILYQYWARWACWK 279 
XP_009289708  195 TQRHQILYEILARTPYg----ALKRGEV-GIGRLVSEKVLTAAFPLHEGPFQlpKtqeDPQCLNMRQILHHYWARWACWR 269 
XP_014967030  255 TKRHQILFEILAKTPYg----HEKKNLL-GIHQLLAEGVLSAAFPLHDGPFKtpPegpQAPHLNQRQVLYQHWARWGKWY 329 
Q14AT5        195 TKRHQILFEILAKTPYg----HEKKGLF-GIDQLLAEGVFSAAFPLHDGPFSavPessQVLGLIQRQVLFQHWARWGKWN 269  house mouse
XP_004743842  212 TKRHQILFAILAKTPYg----HEKKGLF-GIDQLLAEGVFTAAFPLHDGPFRtpLegtQASGLTQRQILFQYWARWHKWY 286 
XP_016280183  174 TQRHKIVYEILEKTPFg----HQRRGLF-GIQQLLSQKVFHAAFPPHDGPyqipakglAPHELNQRQILFRYWAKWSKWR 248  gray short-ta...
XP_007236829  192 TQRHQILYEILSRTPYg----AMKRGEV-GIARLITEGAFTAAYPLHEGPYHmpRgpaGPESLSTRQILYQYWARWACWK 266  Mexican tetra
6BGI_A        313 KYQPI 317 
XP_002117000  269 QFQPL 273 
EDO48048      237 KYQPL 241 
XP_015217201  280 KYQPL 284 
XP_009289708  270 KYQPL 274 
XP_014967030  330 KYQPL 334 
Q14AT5        270 KYQPL 274  house mouse
XP_004743842  287 KCQPL 291 
XP_016280183  249 KYQPM 253  gray short-tailed opossum
XP_007236829  267 KYQPL 271  Mexican tetra
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