1E4K,1F2Q,2FCB,3D5O


Conserved Protein Domain Family
Ig2_FcgammaR_like
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cd05753: Ig2_FcgammaR_like 
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.
Links
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Statistics
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PSSM-Id: 409411
Aligned: 13 rows
Threshold Bit Score: 113.167
Created: 18-Sep-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Fc binding site [polypeptide binding site]
Evidence:
  • Structure:1E4K_C; human IgE Fc fragment bound to its high affinity receptor FcgammaRIalpha based on 3.5A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #                      #      ##                                                
1E4K_C        91 WLLLQAPRWVFKeEDPIHLRCHSWKnt-alHKVTYLQNGKDRKYFh-hNSDFHIPKATLKDSGSYFCRGLVgs-----kN 163 human
1F2Q_A        87 WLLLQASAEVVMeGQPLFLRCHGWRnw-dvYKVIYYKDGEALKYWy-eNHNISITNATVEDSGTYYCTGKVwq-----lD 159 human
2FCB_A        87 WLVLQTPHLEFQeGETIVLRCHSWKdk-plVKVTFFQNGKSKKFSr-sDPNFSIPQANHSHSGDYHCTGNIgy-----tL 159 human
3D5O_F        87 WLVLQTPHLEFQeGETIMLRCHSWKdk-plVKVTFFQNGKSQKFSr-lDPTFSIPQANHSHSGDYHCTGNIgy-----tL 159 human
P12371       110 WLLLQSSADVVLdNGSFDIRCRSWKkw-kvHKVIYYKDDIAFKYSy-dSNNISIRKATFNDSGSYHCTGYLnk-----vE 182 Norway rat
Q28942       109 WLLLQAPRWVVQeGESIRLRCHTWKni-tiQKVQYFQNGMGKKFSh-qNFEYHIPNATLKDGGSYFCRGIIkn-----yD 181 pig
P79107       108 WLLLQVAQRVVNvGKPIRLKCHSWKkt-pvAKVQYFRNGRGKKYSh-gNSDFHIPEAKLEHSGSYFCRGIIgs-----kN 180 cattle
P12314       104 WLLLQVSSRVFTeGEPLALRCHAWKdk-lvYNVLYYRNGKAFKFFh-wNSNLTILKTNISHNGTYHCSGMGk------hR 175 human
NP_001002901 104 WLILQVPYAPVFeGEPLVLRCRGWYdk-vvYKLHYYHDGQAVRYFh-sSANYTVLQARASDSGRYQCSGTMripv-esaP 180 human
XP_854859     27 WLTLRAPSAIFE-GDRIDLICQRKTdkwkiQTMAYYKDGKKLHFSn-eVFSFSIPSAVLSDSGSYSCSATVriyl-ryyS 103 dog
XP_001116874 103 LLILQASHPVFE-GDNVTLRCQVKEde-kaHEKVYYKDGKQLPNSy--NLDFIIVNSVSRDNSKYYCTATWrilsivpiK 178 rhesus monkey
Q6DN72        19 WLYLQAWPNPVFeGDALTLRCQGWKnt-plSQVKFYRDGKFLHFSk-eNQTLSMGAATVQSRGQYSCSGQVmyip-qtfT 95  human
NP_001090998 105 LLILQVPSHAVFeGELLQMQCRGWKvg-slAAVRFYRDGADITKPytsAMQLSIPQAKAHHSGRYHCSADMhsyl-slkR 182 chicken

Feature 1                  
1E4K_C       164 VSSETVNITI 173 human
1F2Q_A       160 YESEPLNITV 169 human
2FCB_A       160 YSSKPVTITV 169 human
3D5O_F       160 FSSKPVTITV 169 human
P12371       183 CKSDKFSIAV 192 Norway rat
Q28942       182 LSSEPVKVTV 191 pig
P79107       181 ESSESVQITV 190 cattle
P12314       176 YTSAGISVTV 185 human
NP_001002901 181 MFSAKVAVTV 190 human
XP_854859    104 KKSNSIKIQV 113 dog
XP_001116874 179 RTSKSLNIQV 188 rhesus monkey
Q6DN72        96 QTSETAMVQV 105 human
NP_001090998 183 RESQGLYISI 192 chicken

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