Conserved Protein Domain Family
HemX

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COG2959: HemX 
Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis HemX, COG0755, no evidence of involvement in heme biosynthesis) [General function prediction only]
Statistics
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PSSM-Id: 442199
Aligned: 159 rows
Threshold Bit Score: 163.597
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_080692480   1 MRSimplryyg----------------anatlstISTssfsqss-----------tittldkANKTmkedkktsttaQSS 53 
WP_011235784   1 MTEenkiene---------------------------------------------evqnneqSSEK-----------STE 24 
YP_096740      1 MANsne------------------------------------------------------eqKKTi----------qPQQ 16 
WP_012071260   1 MTEnnkqeq--------------------hpndaIETtpea------------------etkSKKQq----------PDM 32 
WP_012800102   1 MSKkdkdakdtvkqettpasqddkatsnnnsnsgSDAksdks----------------ssnsQSSAt---------qDKK 55 
WP_014947799   1 MANnnes------------------------spqKEElvkve----------------aekdVIES-----------SAT 29 
WP_082633332 294 KPEpeka------------------------rdkTSAv------------------------TPSS-----------SGS 314
WP_108602537   1 MTQeqqkqdtet--------------nnkqsierVESvdstdaqggqseaddkpsrqasseaTAEQ-----------TQA 55 
WP_115720438 245 MPK-----------------------------------------------------------SPKE-----------AAA 254
WP_117318405   1 MADnkhqtqgnst------------pgnksgtpaPETkpat-----------------astpVPDDkp-------taKTK 44 
WP_080692480  54 PTV-EKKvas----snNVNKAP-------------------VSKL-SLL---AIAL---TLGLGGf---VFYHg--HTQV 97 
WP_011235784  25 EETitaek----------------------------ssgrfFKRL-VWL---IVLI---AIVAA-----AYWG---YTRF 61 
YP_096740     17 PSK----------------VEPdinqqm-------kasffgSKYL-SLIislTSLL---AFLAIi---vSIYSiqlEKQF 66 
WP_012071260  33 PEA-ETK---------SKKQQPdmpekake----kntpqpaINLL-VSL---SFGL---SAVALAt--sGWLY---FQST 86 
WP_012800102  56 AAS-SGAh--------SGKKTPasnts----------sakkpSPM-KWI---IIVI---ILAIIGa--gGYYGwtlWNNY 107
WP_014947799  30 HSE----------------STPsgaakk-------kssgngLLWFvVII---LFLI---VLGMAGa---GYWYy--MQQQ 75 
WP_082633332 315 PKNnKTEnks---atkASDKGPrpa-------------rtgVLWLlAVL---NLLM---VLMLSAa---GYWG---WQQF 366
WP_108602537  56 PSV-DNA---------ASKTKPavaveselrgaaqtvvvkkgGAI-AWF---ALLLalfSIAAIGflgwQFWLn--QQKF 119
WP_115720438 255 PSE-QPKv-------aKVTPPPravkan---------saklpMAV-AVL---ALLL---GAGALGl--sGWQY---YQQQ 305
WP_117318405  45 PTA-TPPtggrsgaakSTRRNPrss--------------tkgLWLvVII---IFLL---VLALAGa---GYWYw--QQQG 98 
WP_080692480  98 -ENQ-KKTIASLQ---TE-----LAD-LKQTTkdsiihdlqnnitEAVNRQNQ-QL-AT----LEQRV--DDQLNEQQKA 158
WP_011235784  62 -PGLfKTDSEQVS---EQp----QEDpIETRF-------------KQLERSVG-NL-EQ----QLQNTvqARELDKLSNT 114
YP_096740     67 -QNH-Q-----LVe-nKN-----LTDe-----------------lERIKVEQN-TV-QK----LLDNN--ANHLQQIQSD 108
WP_012071260  87 -QSTlHKDIQQLT---TK-----QTD-FDNKLnant------lnkSQFNQLIE-QV-KT----SEQTI--LLQKNELAVQ 142
WP_012800102 108 -QSA-Q-EKASTL---DQ---------LQQQV-------------QQQQGVIN-NL-ES----ESSQQ--ANELSQVNHQ 151
WP_014947799  76 -SAS-KDSESALQtttSQ-----LNT-IERER-------------AGLVASID-KV-AR----TNQTL--ESTVAELKAQ 126
WP_082633332 367 rLAQ-QAEDSGLEq---------LAAdEQRQR-------------QQLTQQLSeQL-DSaeraRQQDM--QSQQQALQQR 420
WP_108602537 120 -DQS-Qa---lLE---QQ------QQ-KQSEW-------------QATQVKNQ-QAfTQ-------QV--ERFIEQFQQQ 161
WP_115720438 306 -----------LA----------LAH-------------------KAPTVSPS-QL-ND----AVSDL--NAKLSALSSG 337
WP_117318405  99 -AQR-AQINAQLNe-hQQaqldrLKT-VEQQN-------------RELQQQLA-QL-DE----SRQQL--TSVVEQLSSK 153
WP_080692480 159 QqqltnqindalKLNEQNIYNLNERLSSMSAA--NYNVWLISQANYLVHLAGRKIWNEQDYATARLLLKNADASLAQTND 236
WP_011235784 115 Dqqle----relTSLRQSLEDLRDDMRKTPAE--KAAYWRLLEIKQTLSAAARMMWSQDDYKAALQLLKLADQQLAGIDS 188
YP_096740    109 L-----------TSKMDSLNKELQTAMKQKLY--QNNDWLLLKARYYLELAQINVHWSDNFNTSVALLQQADALLKGMNI 175
WP_012071260 143 Q-----------AQQDEKLLSLESKLNRLNNT--TKEDWKLAEAEYLIRLANQRLLLESDNSGAVTLLINADDILNELED 209
WP_012800102 152 Lsl-------qlEQLQNELKITQQKITSTDE---QQNQWMLAEAEYLIRQASYKLHYTDNAKTIVGLLQAADRQVLAMND 221
WP_014947799 127 N-----------EKLTLQAESTLEQLNNMEGR--RPADWLIAEADYLVRMAGRKLWLENDVRTAILLLVNADKRLKSLAD 193
WP_082633332 421 L-----------AEFEQQLSANQQQLQQVKGR--RPNDWLLAEAAYLVRMAGRKLWLEKDVQTAILLLESADTRLEDLSD 487
WP_108602537 162 Aqq-------qaRQNQTQLDALIKEIKAKSAS--SDEATARADVKQLVSIAGRKIWLAQDLVGAINALEAAQARISKYKN 232
WP_115720438 338 Qqq-------alGQQQNRLADIQGQIDKLWKSqqKTISWPREEAAMLVRMANRRLYLAQELNVAQALLKDADASLKKLPE 410
WP_117318405 154 T-----------QQIQRQSQQALAELDNIEGK--RPSDWLLAEADYLVRMAGRKVWLEKDIRTATMLLQNADTRLSELAD 220
WP_080692480 237 PS-LIPARQAITEDINSLSQVSFIDYDGIIMNLIGLSESLNELP--LVGNyKQidlgmtqhddavaSNhtessntdttsA 313
WP_011235784 189 RN-AIRTREKLAGDIERVNAAVKADNTDLAMQLVGLQQRVSDLPdeVN---SN-------------QQrlssd------- 244
YP_096740    176 PK-IFTIRQTIAKEIAQLKSISVVDITGILSQLDAAQAAINNLS--IQSV-VD-------------QQevlnh------- 231
WP_012071260 210 PI-VFATRKALAKDIQALKSISQFDLEGAYLKLNALYDNVQTLP--QREP-SK-------------EWq----------T 262
WP_012800102 222 SS-LQSLRQAINNDINIVRASGALDIEGVAIKLQSLKPLVEDLE--LATV-QL-------------PDa----------E 274
WP_014947799 194 PS-VLPVRANLAEDIQTLQQLNPVSQSSVALALTGMIAQIDKLP--LDTF-EK-------------PQ-----------D 245
WP_082633332 488 PS-LLPVRQVLSDDIQQLRQINPQPLTKLALQLGALANQVDALP--LDMV-VL-------------PD-----------A 539
WP_108602537 233 AK-WLPLRQALANDIGLIQGLPRPATEDTYLQLVTLANEMASFP--IFVV-PE-------------PQ-----------Q 284
WP_115720438 411 STdVLAWRQAIAADLATLAAQPKIDRTELAMRLEALSKQVPELA--LNTV-KL-------------PKl----------A 464
WP_117318405 221 PS-VIPVRELLAKDIQTLRQINPVSRTSVALAVSGMLAQVDNLP--LDTF-EQ-------------PGgeqs-------- 275
WP_080692480 314 QGInsgvdsdkthndkqsiTTS-ISDWSSNL-LTNTKNfMAKFITIENLDekennfktclskagldekqmlrcQIFKEPL 391
WP_011235784 245 ---------------tqnvSGD-VNDWQTNL-SANWQSfLDNFIRIQPVD-----------------------SDPKPLL 284
YP_096740    232 --------------itkseESG-KTGWRNRL-QDSVNf-LEKLVVIRRHN-----------------------ENIQPLI 271
WP_012071260 263 NTIekt----------ketDDStTSKi-TSVlESFWKS-IRSLVVINYNH-----------------------KPIKALL 307
WP_012800102 275 DTEsteat-------dgttEEE-TSGWQRFK-DSFSSA-LSQYYTVHHYD-----------------------ESMKPFI 321
WP_014947799 246 ANAedt-----------tlSES-ADDWQENL-AKVWRSlVNDFLTIKTIE-----------------------GPVEPVL 289
WP_082633332 540 EEQqvq----------eelSDS-VSDWRMNL-KRSWQGiVDDFITVRRRT-----------------------EQTRPLL 584
WP_108602537 285 PKedl------------tlSNS-VEHWWPNL-LKSARSmTIGFFEVSQRQ------------------------NIQPLV 326
WP_115720438 465 DQEqdl-----------spTQD-EGDWRNNL-EKSLESfADKFIKIRKRQ-----------------------DGVKPLL 508
WP_117318405 276 ----------------selSDS-IDEWQQNL-KQVWRNiVDDFISVSRTD-----------------------TPIEPVM 314
WP_080692480 392 TLEQSLYLRENIRFRLLIAAQAVPRHHDLIYQRALSDALLWVNAYFDNNAPTVKAFVDDLDDLLSQSISdQSV------- 464
WP_011235784 285 SATQRTAINERIQLLFTLAQQAAVKNNDELWQSYLDQLSKLIAQV-KGDGAASQDIISRIQSLGQEDFE-QQS------- 355
YP_096740    272 SPLYESAIKENIRLNLQEAQWAILNNNPAVYQFALNQAIANLKRVFNESSQNTDVLIKQLSTLQNVKLT-QEK------- 343
WP_012071260 308 PPTEYQELITGIQLQLEIAQVALIKGEPMIYQQALSRVANATTEHFETQSNIVTTFLASLTVLQQLNPS-PDL------- 379
WP_012800102 322 SPQHDALLRQNILLNLQTAQLAAIQHNDAVYQNALGEIEDWVSQYFKSEPATTTAFMQQLDELLQMSVA-LNL------- 393
WP_014947799 290 SLEAQFLAKEQLRLQLMHAQTAALQGDAGLYSQSLQYAQTLIIEKFDTEKSQVTGFVDALQNLIATDIS-RPI------- 361
WP_082633332 585 SDKQQWLVREQLRLYLLQAQHLVLREQAELYQSFLSEAQNLLEMYFAPQAPAVAGFSSSLAELQQTELR-RDY------- 656
WP_108602537 327 SPSQEANLRHNLASKMVSAQLALLNNKQSVYSASLLDAAKWLNEYYAQNYPPVQQAISKLNELALMPIV-TSFdqvklss 405
WP_115720438 509 GPSHEAYLREDLRLALSEAKLAMFAGDKGRYQASLRQVRDWVDSYGDANNDAVKAFVKALNALLDSPVS-LSL------- 580
WP_117318405 315 SQQQQWLNREQLKLQLMQAQSAAVGAQQTLYEQSLQNALKQLINNYDIEDAAVKGFVDSVQNLLETDVS-QQL------- 386
WP_080692480 465 --------PNKLESISELEKLM-QT---RVHSML 486
WP_011235784 356 --------IEQLESLDFIAQAI-EQgdas----- 375
YP_096740    344 --------PVVGQAIPLINQMI-DN---KELLVD 365
WP_012071260 380 --------PLPRESLMAMKSLM-KE---WNNRSS 401
WP_012800102 394 --------PQQLQSLRVIEQIT-GR---QSQASN 415
WP_014947799 362 --------PTELASQKPLERLL-DS---RVKQVF 383
WP_082633332 657 --------PQQLQSAVALEELL-RQ---RLSSQY 678
WP_108602537 406 fihvestqPKIIKALAAPKLSQpASpalSQPESM 439
WP_115720438 581 --------PNKLDSLRMAEAAQ------------ 594
WP_117318405 387 --------PESLQSTQPLQRLL-EQ---RVQGAF 408
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