2DIX


Conserved Protein Domain Family
DSRM_PRKRA_rpt1

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cd19889: DSRM_PRKRA_rpt1 
first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
PRKRA (also known as interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X (RAX), PKR-associating protein X, protein kinase, interferon-inducible double-stranded RNA-dependent activator, PACT, or HSD14) is a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. PRKRA contains three double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Statistics
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PSSM-Id: 380718
Aligned: 5 rows
Threshold Bit Score: 112.699
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on structure evidence that Homo sapiens TARBP2 (5N8L) binds siRNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ## ##  ##  ##      #       ### # #                                  ####  #    
2DIX_A         7 GKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDI-------------------TCTGEGTSKKLAKHRAA 67  human
O75569        32 GKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDI-------------------TCTGEGTSKKLAKHRAA 92  human
XP_006012627  30 GKTPIQLLHEYGTKTGKAPAYELEKSEGQAHLPSFTFKVTVAEV-------------------TCTGQGRSKKSAKHAAA 90  coelacanth
EMP26370      32 GKTPIQLLHEYGTKAGITPEYNFEKAEGQVHLPSFTFKVTVGEItgtddmlwlcdihdvtetqSLAGEGHSKKIAKHRAA 111 Green sea turtle
Q7ZYA5        29 CETPIQLLHEFGTKTGNHPVYTLEKAEGQAHNPSFTFRLVIGDI-------------------TSLGEGPSKKTAKQKAA 89  African clawed ...
Feature 1                  
2DIX_A        68 EAAINILKAN 77  human
O75569        93 EAAINILKAN 102 human
XP_006012627  91 EAALNILKGD 100 coelacanth
EMP26370     112 EAALNVLKGN 121 Green sea turtle
Q7ZYA5        90 EFALNILRGD 99  African clawed frog

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