Conserved Protein Domain Family
AceA

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COG2224: AceA 
Isocitrate lyase [Energy production and conversion]
Isocitrate lyase is part of the Pathway/BioSystem: TCA cycle, glyoxylate bypass
Statistics
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PSSM-Id: 441826
Aligned: 107 rows
Threshold Bit Score: 788.261
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_066598782  18 PGD---QTQTAA--ELALEWAADPRWEGVRRDYTAEDVIALRGAVREERTLARRGAEKLWDLIHEngtpenPEWVAALGA 92 
ACR41301       4 RDK---WSEEEK--RLEYEWSEDPRWKGIKRNYKPSDVVKLRGSIRIEYSIAKLASHKLWNLLNT------EPYIATFGA 72 
BAJ50994       1 -MNpllMADTPE--DLERVWRT-PRWNGVSRKYTAEDVLKLRGSWKLDYTYARVTSEKFWKMLHT------DDYIFTAGA 70 
WP_011958845   3 AVN---RDQEIA--ELERRWATDPRWQGIRRDYSAADVVRLRGTLKIEYTLANVGARRLWDLLQT------EPYVATFGA 71 
WP_012844738   3 QPI---AAVKAA--RLEAEWRSNPRWAGIRRPYAAEDVLRLRGSVEIAYTLADRGARRLWELLHT------EPYVAALGA 71 
YP_145102      5 TPE---MQREAE--ALRREWETNPRWKGVRRDYRPEDVVRLRPSVMVEYTLAKRGAEKLWKLLHE------RPYVHTFGA 73 
WP_013157498   4 TPE---MKLEAE--KLRKEWQTDPRWQGIKRDYTAEEVVRLRPSLQIEHTLAQKGAERLWELLHQ------RPYINTFGA 72 
WP_013178028   3 QPQ---TTQDAQ--TLASLWSTDPRWSGIERPYSAEEVLALRPSVKVEYTLARRGAEKLWDLLHT------EPYVNTFGA 71 
WP_042502027   2 EER---IRQEAA--RLEEEWRTDPRWRGIRRNYSAEDVVRLRGSVRVEYTLARQGAQRLWELLHS------EDYVAALGA 70 
WP_053239151   8 PER---RTDVANpiQKDTDSFSDPRWKGVVRPYSEEQVLKLRGSVRVEYTLADKGARRLWKSMKE------KPFVRTLGA 78 
WP_066598782  93 LTGNQAVQQVRAGLKAIYLSGWQVAADANLSGQTYPDQSLYPANSVPAVVRRINNALLRAGQIEGAEAvasgadatnnG- 171
ACR41301      73 LTGSQAVEMAKAGLKAIYVSGWQVAADNNLSNQTYPDLSLYPSNSVPNLVKRLNNALLRADQISWSEG----------K- 141
BAJ50994      71 LTGNQAIQLVEAGIKAIYVSGWQVAADNNQSGNMYPDLGLYPSSSGPDLVRKIVKALQRADQIQHLEN----------Rp 140
WP_011958845  72 LTGAQATQMVRAGIKAIYMSGWQVAADANLAGQTYPDQSLYPSNSVPALVRRINNALMRADQIHASEG----------H- 140
WP_012844738  72 LTGNQAMQQVKAGLKAIYVSGWQVAADANLAGQMYPDQSLYPSNSVPALVRRINNTLLRADQIHHAEG----------D- 140
YP_145102     74 YTGAMAVEMVRAGLEAIYLSGWQVAADANLAWQTYPDQSLYPYNSVPQIVKRINNALMRADQVERIEG----------R- 142
WP_013157498  73 YTGAQAVQMVKAGLEAIYLSGWQVAADANLAAQTYPDQSLYPANSVPQVVRRINNALMRADQIERAEG----------V- 141
WP_013178028  72 LTGAQAVQMVKAGLKAIYLSGWQVAADANLAAHTYPDQSLYPANSVPAVVRRLNNALMRADQIDKLEG----------N- 140
WP_042502027  71 LTGAQAVQMVKAGLKAIYLSGWQVAADANLAEQMYPDQSLYPANSVPAVIRRINNALRRADQIHWAEG----------D- 139
WP_053239151  79 LTGGQAVQMARAGLDGIYCSGWQVAADANTSGHTYPDQSLYPADSVPKLVERINNALARADQIDWSEG----------K- 147
WP_066598782 172 TGIDWMAPIVADAEAGFGGPLNAYELMASMIEAGAAGVHWEDQLASEKKCGHMGGKVLVPTGQHIRTLNAARLAADVAGV 251
ACR41301     142 RDIDYLLPIVADAEAGFGGPIHAFELTKALIEAGAAGVHFEDQLAAEKKCGHLGGKVLIPISAFIRVLNAARLASDVLGV 221
BAJ50994     141 SKIDYMAPIVADGEAGFGGPLHAYELMKAMIEAGAAGVHFEDQSPSERRCGHLGGKVLVPTKRFTSILSAARLAADVLGV 220
WP_011958845 141 NDIYWYAPIVADAEAGFGGPLHAFELTKAMIEAGASGVHFEDQLASEKKCGHLGGKVLVPTSQFIRTLTAARLAADVLDV 220
WP_012844738 141 DSIDWLVPIVADAEAGFGGPLHAFELTKALIEAGAAGVHFEDQLASEKKCGHLGGKVLVPTGQFIQTLVAARLAADVMGV 220
YP_145102    143 VTRDWYVPIVADAEAGFGGALNVFELTKAMIEAGAAGIHYEDQLASEKKCGHLGGKVLVPTGQHIRTLQAARLAADVMGV 222
WP_013157498 142 SGRYWYAPIVADAEAGFGGPLNAFELMKSMIEAGAAGVHWEDQLSSEKKCGHLGGKVLIPTQAHIRTLQAARLAADVLGV 221
WP_013178028 141 TATDYYAPIVADAEAGFGGPLNAFELMRAMIEAGAAGVHFEDQLASEKKCGHLGGKVLVPTGTFIRTLAAARLAADVMDV 220
WP_042502027 140 DSIYWMAPIVADAEAGFGGPLNAFELMKAMIEAGAAGVHYEDQLASEKKCGHMGGKVLVPTSQFVRTLTAARLAADVCGV 219
WP_053239151 148 TGRDYFLPIVADAEAGFGGPLNAYELMKNMIKAGAAGVHFEDQLASEKKCGHLGGKVLVPTAQFERSLLAARLAADVCGV 227
WP_066598782 252 PTIIIARTDSLAATLITSDIDERDQAFL-TGSRTAEGFYDTANG--ADVVIMRGLAYAPYADLLWVESSEPDLELAQRFA 328
ACR41301     222 PTILIARTDAPNAKYLSNDVDETDNQFL-TGKRTSEGYYEIRGG--IEYAIARGLAYAPYADLLWFETSKPDLEEARQFA 298
BAJ50994     221 PSVIIARTDAIGAQFLTSDADPVDREFL-TGSRTSEGYFELKPGtaLDIAIQRGLSYAPYADLLWFETSKPSLEEAKRFA 299
WP_011958845 221 PTVLIARTDAQAATLLLSDADEYDRPFI-TGERTPEGFYRVKSG--LDAAIARGLAYAPYADLIWCETAHPDLDEARRFA 297
WP_012844738 221 PTIIIARTDANAATLLTSDIDERDRPFL-TGERTPEGFFRVRAG--LDQAIARALAYAPYADMIWCETSTPDLDEARRFA 297
YP_145102    223 PTVIIARTDAEAATLITSDIDERDKPFIlPDERTPEGFYRFKNG--IEAGIARALAYAPYADVIWMETSKPDLEEARKFA 300
WP_013157498 222 PTLIIARTDAEAATLLTSDVDERDRPFV-TGERTPEGFYRVKNG--LEPCITRALAYAPYADLLWMETSTPDLEVARKFA 298
WP_013178028 221 PTVLIARTDAHAATLLTSDVDERDHPFL-TGERTPEGYFYVRPG--LEASVARALAYAPYADLIWMETSTPDLEEARRFA 297
WP_042502027 220 PTILIARTDALGATLLTSDVDPYDQPFI-TGERTPEGYFRVRNG--IEAVIARGLAYAPYADLLWFETARPDLEEARQFA 296
WP_053239151 228 PTVLIARTDAESAKLLTSDIDDRDKPFC-TGERSAEGYYYVKQG--IEPCIARAKAYAKIADLIWMETSTPDLKLAKQFS 304
WP_066598782 329 REIHAQFPGKKLAYNCSPSFNWKSHLDDDQIAAFQRELAACGYAFQFITLAGFHALNHSMFTLAKDYSERQMSAYVDLQE 408
ACR41301     299 EAIHTHYPGKLLAYNLSPSFNWKKFMDDSKISRFMTELGEMGYKFQFITLAGWHLINYHTFKLARAYRNEGMPAYVRLQE 378
BAJ50994     300 DAIHRKYPGKLLAYNMSPSFNWLKVVDGDTLREFNQKLGQMGYKFQFITLAGFHTLNASMFELAKKLAEEGMMAYANFQA 379
WP_011958845 298 EGIHAKFPGKMLAYNCSPSFNWKRYLDEATIATFQRELAAMGYKFQFITLAGWHMINYYAFELAKAYAAEGMTAYVRLQQ 377
WP_012844738 298 EAIHREYPGKLLAYNCSPSFNWKKHLDEATIARFQRELAAMGYKFQFITLAGFHTLNYAMFELAYDYAREGMPAYVRLQQ 377
YP_145102    301 EAVKKEFPDKLLAYNLSPSFNWKKFLDDETIAKFNRELGEMGYKFQFITLAGWHALNYYIWELAKGYKERGMPAFVELQQ 380
WP_013157498 299 EAVHREFPGKMLAYNCSPSFNWKKYLDAETIAKFQRELGAMGYKFQFITLAGWHNLNYRTFELAKGYKERGMSAFVELQS 378
WP_013178028 298 EAVHEHFPGKGLAYNCSPSFNWRRHLDDATIAAFQRELGAMGYRFQFITLAGWHTLNLRTFELARGYAESGMSAYVALQE 377
WP_042502027 297 EAIHRQFPGKLLAYNCSPSFNWKRHLDDDTIARFQRELAAMGYKFQFITLAGFHALNASMFELAHGYARTGMTAYVRLQQ 376
WP_053239151 305 EAVLKDNPDKMLAYNCSPSFNWKKNLDEATIAKFQKELGAMGYKFQFVTLAGFHVQNYSTFMLSADYNERGMAAYSELQQ 384
WP_066598782 409 AEFASEADGYTATRHQREVGTGYFDRIATALN-PTSATLALAGSTEAEQF 457
ACR41301     379 SEFQAQAEGYTAVSHQREVGTDYFDLVLTIASgGEASTTAMEGSTEAEQF 428
BAJ50994     380 HEVELEKMGYRAFKHQRFIGVHYYDEVLMAIE-GKEAVSALAESTENQQF 428
WP_011958845 378 AEFAAEQHGYTATRHQREVGTGYFDEVSTIISgGLSSTTALAGSTEEEQF 427
WP_012844738 378 KEFAAMEKGFTAVRHQREVGTGYFDAVRTVITgEQASTVALAGSTEAQQF 427
YP_145102    381 KEFAAQKEGFTAVKHQREVGAGYFDEVVLALTqGQASTLALKGSTEEAQF 430
WP_013157498 379 LEFAAEKDGFTAVKHQREVGAGYFDEVLLAITgGQASTAALVGSTEEAQF 428
WP_013178028 378 EEFARERDGYTATRHQREVGTGYFDRVLQTATaGQASTAALVGSTEAEQF 427
WP_042502027 377 REFEMEELGYTATRHQREVGTGYFDRVSEVISgGQSSTLALKGSTEEEQF 426
WP_053239151 385 KEFAAESVGYTSTKHQHEVGTGYFDVISEIVSqGQSSTKALKGSTEEDQF 434
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