The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.
Structure:1HXM; human gamma/delta T-cell receptor (TCR) gamma chain IgV domain forms interface with delta chain IgV domain, contacts based on 3.5 A distance.
Structure:1YPZ; mouse gamma/delta T-cell receptor (TCR) gamma chain IgV domain forms interface with delta chain IgV domain, contacts based on 3.5 A distance.
Jiyao W et al.(2023). "The conserved domain database in 2023.",