Conserved Protein Domain Family
AKR_unchar
?
cd19099: AKR_unchar 
uncharacterized aldo-keto reductase (AKR) superfamily protein
This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Links
?
Statistics
?
PSSM-Id: 381325
Aligned: 59 rows
Threshold Bit Score: 174.814
Created: 24-May-2018
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###                              #    #                               # 
NP_712080  51 RILSKIAFGSYRVgle------steHEKSIELSLSMGfNVIDTSSNYgdgeSESLIGKVLQkkiqkgelkRENVFIITKV 124 Leptospira interro...
SFV33424   11 MQVSEIGFGGSRIggffanknggqeALKVLPESLDSGiTFYDTADMYaqgeSEALIGKAFRg-------rRQQVVLATKG 83  Hyphomicrobium facile
OLE77520    6 LTVSAIGIGCARIggvfdr-tdrasHLRLLRHALDLGiTFFDTSDLYahgeSERLLGEALRg-------sRSRAIIATKL 77  Chloroflexi bacter...
CCE10425    9 VVQQRLGLGCARLgsvlg--rdragAFTLVQAAFDRGiRLFDTANIYgqgeSERILGAALGs-------rRKRVTLVTKA 79  Bradyrhizobium sp....
EEF57261   11 IDCSIIGLGTGRLasvsgg-vsrtaAVNLFGVAEDLGiNLIDTADSYaqgeCEKIIGQALQg-------kRSQFIITTKA 82  Pedosphaera parvula
KJL43810    9 LEVSILGLGTSRLasigtg-rsksdAKALFDACRECGvNVIDTADAYgstmAERWIGELTRa-------dRERWVVVTKI 80  Microbacterium tri...
OYX86485    6 NTISPLGIGTSQIaslgrg-inhseAKRLFDTALDYQvTTIDTADTYgsgdSERMIGKAIQa-------kRSDFYVITKA 77  Flavobacteriales b...
KQV44054   17 LTASVLGLGTSRLtsvstg-lsrrqGLGLIAAAADQGiNFIDTADIYgqgdSEAVIGQAIKg-------mRDRFIVATKV 88  Rhizobium
GBE43738   38 AALSALGIGCARMgsirnh-tpvseIRRTLAAALDHGvNVIDTAGIYaqgdSERIIGEAIAg-------rRDQAFVITKI 109 bacterium BMS3Bbin10
ESQ91105   12 LLVSPIGLGCSRLgsvlg--arhekSEELIKVALDNGiNFFDTSNIYaqgeSERILGKVTKg--------VPDVVICTKV 81  Asticcacaulis bene...

Feature 1                                                                                ##   
NP_712080 125 GYIqgknleivtelentn--------------rafpeityyqegcyHCIHPFFLEDQLEYSLKRLglETVDVFLLHNPEY 190 Leptospira interro...
SFV33424   84 GYClpaqrklmqrikplvrpiv-----halglkrsklpslvsgalsQDFSPSYLTAALEASLKRLqtDYIDIYQLHSPPP 158 Hyphomicrobium facile
OLE77520   78 GYRipmqssfasrakpllrpll-----mragihrervplairgtpsQDFSPGYVVQAAERSLKRLgtDYIDLYQLHSPPR 152 Chloroflexi bacter...
CCE10425   80 GQYfpawmrvakplksavtpli-----rrsgagrhliskareaplpQNFSDHGLRASIDASLRRLntDYADILLLHSPPA 154 Bradyrhizobium sp....
EEF57261   83 GYSfssvagglrllkplakkvl-----kmfkggrslagsvrtnvsrQDFTAAYIQRAVDSSLQRLqtDYIDIFLLHTPPL 157 Pedosphaera parvula
KJL43810   81 GLPtvdlpgpfrvfgq-----------------rarkttqaragsaFALDHASLTRSIERSLKRLrrDRIEIFLLHLPPA 143 Microbacterium tri...
OYX86485   78 GFPyvhlpgflsplnq------------------igkkvlqstggnKSYSKKYLIQSLEKSLKRLktDYVDAFLLHEPLG 139 Flavobacteriales b...
KQV44054   89 GYRfgeksgflvkampllkralrpfkgarrfaasmrnnahdsnlitQDFSAAYLVAAVDNSLRRLgtDYVDILYLHDAPS 168 Rhizobium
GBE43738  110 GFShgshsrlvtrlkpvlrlvs-----rysrafdakldrardavqsQNFSPGYLMDALDGSLRRLglNEVDGLLLHSPSG 184 bacterium BMS3Bbin10
ESQ91105   82 GKYlplakqlivpfkpiisfla-----sknkavrggvrqarsnglpSDWNPAKIRKSVESSLRRLqrDHVHVLMLHSPPH 156 Asticcacaulis bene...

Feature 1                                                 ##                                  
NP_712080 191 FLmdrekhnvpkekateqyyeriksSFRFLEQKRKEGkILYYGISSNTFSENPEkytstslikilkiakevqselgleeS 270 Leptospira interro...
SFV33424  159 AFlhsd---------------afgeALETLEKLKSQGkLRFYGVAVEAAEQAELcl---------------------saP 202 Hyphomicrobium facile
OLE77520  153 PIlee------------------geFIEPLERLKAAGkIRHWGVSCETIDHALLal---------------------rhS 193 Chloroflexi bacter...
CCE10425  155 DViar------------------gdALGLLDKMREAGkAIKIGISCEDIQTGLLal---------------------ndP 195 Bradyrhizobium sp....
EEF57261  158 QVmsd------------------aqLFDLLRQLKQQGkIRHFGVSSNDPVVLGKaa---------------------slA 198 Pedosphaera parvula
KJL43810  144 SIved------------------deAHEILQEAQRSGvIAHFGVSTDMPRTIAAvr---------------------daW 184 Microbacterium tri...
OYX86485  140 VDlla-----------------fddFWEALELIKKNGmANNIGISTNDSSAYMMas---------------------nrI 181 Flavobacteriales b...
KQV44054  169 GFeks------------------egLFEALSLIQRAGkVRYFGISAEHDDALKTac---------------------snP 209 Rhizobium
GBE43738  185 QVled------------------drVAEFLARAKRQGkVKHFGASVETLPEARAal---------------------dmE 225 bacterium BMS3Bbin10
ESQ91105  157 EFlqr------------------gdAIGALASLKAEGkIGVIGVSVDDPVAAQVal---------------------ddN 197 Asticcacaulis bene...

Feature 1          #                                 #######                                  
NP_712080 271 GFAVVQFPGNLLesgfldpkfegknLISIIHENGLLPLINRPLNAIsnsgniyrlsydpkkesehilnllkerldtiykr 350 Leptospira interro...
SFV33424  203 GIGSLQLGFGLLdlea-----ldqgILAAAESRGLGVIARGCFGGGllkdglneaqleaatpk----------------- 260 Hyphomicrobium facile
OLE77520  194 GIASVQLLLNVLdpaa------laeAIPRAADAGVGVIARQCFAGGlvtradadtdldrlipdka--------------- 252 Chloroflexi bacter...
CCE10425  196 RVEAVELPLWPPtea-------mdrFLDRARRQAVFVIGRGLINAAqpass----------------------------- 239 Bradyrhizobium sp....
EEF57261  199 GLSVVQTPVNPLqmg-------segALKKLAASKVGIVANQVFLSGklvgsqapnedearqvs----------------- 254 Pedosphaera parvula
KJL43810  185 GCPVAETAVNPWslas-----aapaSMTGVDLIANRVMGSEALRVQlldreaas-------------------------- 233 Microbacterium tri...
OYX86485  182 KLDLVETGMPYGqde-------nssVFSLAKNDHIPVVLNEVLKPYksllenagvva----------------------- 231 Flavobacteriales b...
KQV44054  210 LLRLVQTDLHPSrs---------reTFSSIEDAGRGVVVNKVFSRGqeeavsaf-------------------------- 254 Rhizobium
GBE43738  226 GLELLQVDIDTArdla------sgpACKIIGQRRIAVFARQVLRPPglapd----------------------------- 270 bacterium BMS3Bbin10
ESQ91105  198 RVEALQIPLHPSsne-------ydeIIETAYSRGVAIVAREVLGGPnvigkk---------------------------- 242 Asticcacaulis bene...

Feature 1                                                                                     
NP_712080 351 eevllavlpqgsykytfrtvtepylnqfqnqnhlnqflertvipilqqliaqiekiggvkvqteyietlnealpileqyv 430 Leptospira interro...
SFV33424      --------------------------------------------------------------------------------     Hyphomicrobium facile
OLE77520      --------------------------------------------------------------------------------     Chloroflexi bacter...
CCE10425      --------------------------------------------------------------------------------     Bradyrhizobium sp....
EEF57261      --------------------------------------------------------------------------------     Pedosphaera parvula
KJL43810      --------------------------------------------------------------------------------     Microbacterium tri...
OYX86485      --------------------------------------------------------------------------------     Flavobacteriales b...
KQV44054      --------------------------------------------------------------------------------     Rhizobium
GBE43738      --------------------------------------------------------------------------------     bacterium BMS3Bbin10
ESQ91105      --------------------------------------------------------------------------------     Asticcacaulis bene...

Feature 1                                #                #####   #  ##  
NP_712080 431 fqkniesrkslyskiinlypnyqswnLSTISLHLLHSsLGKGVVLLGMRkEEYVKDATF 489 Leptospira interrogans serovar Lai str....
SFV33424  261 ---------wqriltlrrlsesfgrpVLETALQFCRAtPGVGVTLLGMHtERHLSENLR 310 Hyphomicrobium facile
OLE77520  253 --------erdtiarvrriaeqrgrrLSELALQFAVGaAGVSVALVGVStEGHLEAAVR 303 Chloroflexi bacterium 13_1_20CM_2_70_9
CCE10425  240 ---------------------ndrwpAARTALTASLArSEISRVLIGTTrLAHLDQVLD 277 Bradyrhizobium sp. STM 3843
EEF57261  255 ----------askdrleilakqkgisLNHLLIQYALMqPGLVSVLSGTTkQEHLKQNVA 303 Pedosphaera parvula
KJL43810  234 ------------------saphraapIARRLLRHAAAvPGVKVILTGTMePAHLRDNAR 274 Microbacterium trichothecenolyticum
OYX86485  232 ---------------llreygksdqeLIGILLAHSIYeKKGQCALTGTRnPNHLIQNVA 275 Flavobacteriales bacterium 32-34-25
KQV44054  255 -------------------aqrhgvtVRQVLLGYALRqPFVASVLTGTTnRDHLSENIA 294 Rhizobium
GBE43738  271 ----------------------aaapAIGEALPAALAvPNVRCAIVGLSsRKHLLAAIK 307 bacterium BMS3Bbin10
ESQ91105  243 ---------------------illgdAVAARMDEASTrRGVTLALLGTTnVDHLKEIII 280 Asticcacaulis benevestitus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap