Conserved Protein Domain Family
Type_ISP_C

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pfam18135: Type_ISP_C 
Type ISP C-terminal specificity domain
This is the C-terminal domain of Type ISP restriction-modification enzyme LLaBIII present in Lactococcus lactis subsp. cremoris. Type ISP restriction-modification (RM) enzymes provide a potent defence against infection by foreign and bacteriophage DNA. This domain interacts extensively with DNA and is known as the target recognition domain (TRD). TRD works by recognising 6/7 base pairs of asymmetric sequence.
Statistics
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PSSM-Id: 465663
Aligned: 78 rows
Threshold Bit Score: 216.351
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAM32310         421 EIFELFSQGVVTGKDNWSFNFSKENLAKNIALCIDTY--NTEREAlvanpAYKLCNDLSKVTWSGSLDKRVRANRELVFD 498 
GAK59511         744 EIFPQSSLGIEFGSKQYLLAFDADTIETFVSNTLLNP--QISDYM-----LEEQYGLKTTSGWRLQQIRQIE--LVSGYN 814 
Q3SKA9           702 EFMPLHGNGVVTKRDRLNIHETESGVREVIDDFLTRT--EEVVRA-----KYKLPKDVRDWRYSWALDD-----IKANHI 769  Thiobacill...
Q0ASV4           712 EFAPQHAIGIITKRDGVVLSSNREKVESLVQDLALLS--VDEVRA-----KRPEIHDTAGWSLSRAKEN-----IIACGT 779  Maricaulis...
EFL88046         725 NLFSSNVLGFQTHRDGFAIAETLKELNSRIEDLSNKNltDATLRE-----KYKV-RDNRDWNLSQA-RERLA---QYEKP 794 
WP_045576530     745 DLFINKNTGIQTKNDKLTIGFKKSDTQLVVNDFKCLQ--KFEIEK-----KYG--SKSGTWSIESAQ-------SDLSTN 808  Desulfospo...
EIJ35287         703 ELFVVQSIGIATARDSFCIKFSENEVKKLVGDFSLMQ--IEDARE-----KYQLGKDVRDWKVEWA-KADLLKS---NID 771 
sklmb:Mhar_0139  116 SLFGLYSSGIQTKRDKIAIAQGISELRAILRDFASME--PEVVRS-----KFDLPKDGRDWKIKWASEHALA----IVND 184 
WP_013705746     689 KIFPVNSVGLVTARDHLTIKWSRAEVWETVRDFVALP--EDEARE-----KYNLGKDVRDWKVHLAQA-DIK---LSGPN 757  Desulfobac...
WP_015083613     694 NIFTDSTPGIVTARDNLTIHWQNNEVWKTVIDFSKIS--AEEAII-----KYNLTDDTRDWKVYLA-QQDIKQ---SKIS 762  Anabaena s...
BAM32310         499 ESRIRICSYRPFTKEFLYFDNG---YNHSHCqmDKIYPFG-NKgeaivcingdfENVAIQVLGV-GATHQFS-ALTSNGI 572 
GAK59511         815 PNLLVQCSESPFNILYTYHS-L---LLRRPQ--LDILQNL-HQ-----------SNKALLTLRQtRTSEGGH-FFAVNTI 875 
Q3SKA9           770 SAPIVRIQYRPFDPQYIFYSGNargLVGWPV--KQIMRHYlDG-----------QNIGLLAPKA-IRDSQFAhAFVTRDI 835  Thiobacill...
Q0ASV4           780 KEKIKPVLNFPFDVKYTYHSDRslgFL--ARpvYPTMRHF-YN-----------DNIGLMFTR--ITKDAFS-VFVTKFM 842  Maricaulis...
EFL88046         795 NDFVSLCDYRPFDTRYCFLDEV---TMDYPR--TEIVKNFlGL-----------DNLALTVSRQ-QSTVGFR-HAFTAKY 856 
WP_045576530     809 EYTIVPILFRPFDIRYTALTTRsggFLGRPR--YTTMCHMiHS-----------NNVALLVGRQ-NKSETIDsFLVTNCV 874  Desulfospo...
EIJ35287         772 ENKVEKIFYRPFDERYTYYTGNsrgFHCMPR--NDVMQHLvSG-----------ENIGICFNRRvEENRRFTdVFLFKGI 838 
sklmb:Mhar_0139  185 EKGLSPILYRPFDNRWTVIDDRskgFVAYPR--FDVMRHM-KN-----------NNLGLILTRQ-LSLSTFQhAWVTQNA 249 
WP_013705746     758 KKKIYPIFYRPFDTRFTYYTGQtrgFMCRPR--FEVMRHLlPG-----------KNLGLCASRGvEIGGDWEhIFCSKHI 824  Desulfobac...
WP_015083613     763 KDKITSILYRPFDLRYTYYTGNtkgFHSMPR--HQVMRHIvNY-----------ENLALISVRQ-VAEGIFNhILVSDCI 828  Anabaena s...
BAM32310         573 VDLEHIS------KGHCFPLYYYERVEs-STENGqmtmdydkaessafchfeqsekshaqssdktrndnktayyRRKDAI 645 
GAK59511         876 YSKDVISik---dRVTGFPLYLYPTEDaak-qkSlfdvspw--------------------------padeahgGRVPNL 925 
Q3SKA9           836 TEAIFLSgtt-gsNAMNFPLYLYPTEQ--DLDQT-----------------------------------------RRVNF 871  Thiobacill...
Q0ASV4           843 ATHKSASry---dGTYIAPLYLYPAED--ELDQA-----------------------------------------RRINF 876  Maricaulis...
EFL88046         857 PANDCFVstksreANQVFPLYLYPDEP--ELDQT-----------------------------------------RRVNF 893 
WP_045576530     875 SEMKCAErt---iQSYHLPLFVVSKTYq----GS----------------------------------------KLIPNL 907  Desulfospo...
EIJ35287         839 VQLHSLSik---eANSIAPIFVSKEGI-----CG----------------------------------------EKIANF 870 
sklmb:Mhar_0139  250 IDGNTISlqt-reYNYLFPLYLYPTPTedSSRQKsfssad----------------------------wppgkdGRVPNL 300 
WP_013705746     825 IQNHTVSlk---eVNYLFPLYLFPSENpnNNASAgqnsflal-------------------------sepespyGRQVNI 876  Desulfobac...
WP_015083613     829 IDNRLTLsn--kgYAILFPLYLYPTDTp-TLFDSpptn---------------------------------apgGRNPNL 872  Anabaena s...
BAM32310         646 RDEALAFFQNA--------------YNDSSITKEAMFYYIYAILNHKDYIAKYKDNLSKMLPRIPLMQDFWGF---VASG 708 
GAK59511         926 NPKFVAEMARKlgltftpnriadanLSALEFTPEDIFHYIYAIFHSPTYRTRYTEFLKIDFPRVPLTSDVVLFrslCDSG 1005
Q3SKA9           872 DAKLYKRLQALak-----------hPERGVPDELAVFDYIYGILHCPAYRKTYAEFLKLDFPRIPWPASPAEFwdvSDKG 940  Thiobacill...
Q0ASV4           877 DPKLHAKLRKLat-----------hPEFGEPGEVAVFDYIYGVLHSPDYRETFAEFLKIDFPRIPWPATPDVFwsvREKG 945  Maricaulis...
EFL88046         894 DPKIRAEIEKAat-----------sDGGDVPDEVAIFDYIYGVLHCPAYRETYAEFLKIDFPRILYPASPETFadiSAKG 962 
WP_045576530     908 SEPIVKNISNSlglsls---qnviiDSEYSFSSLDLLDYIYAVLYSNRYRERYRELLKIDFPRVPYPTDQEMFwklVELG 984  Desulfospo...
EIJ35287         871 NDEIITKISRIikvpf----slemsNNKESFSALDVVDYIYSILHSPAYREKYNEFLCSDYPRIPYPDNVNMFwnlVQLG 946 
sklmb:Mhar_0139  301 SPEFVADFAEKlglsfv---pdgrgDSEATFGPEDVFDYIYAVFHSPSYRERYAEFLKIDFPRVPLTSDRKKFrrlVELG 377 
WP_013705746     877 NPDFLRHLEEQlgltft---yenqgDRQTFFGPLDVFYYAYATFHSPGYRERFAEFLRIDFPRLPLTGNKTLFaalVDKG 953  Desulfobac...
WP_015083613     873 SPEFITEFSQKldlefi---fdgkgDKKQTFGPEDIFNYIYAIFHSPNYRQRYAEFLKIDFPRVPLTSNSALFwelVIKG 949  Anabaena s...
BAM32310         709 RALAELHINYES--HNKLDSGAfsclakdlhefktsakglfekdfrqkareD--IehlNEGD--FRIET--IKFHA---- 776 
GAK59511        1006 KRLVALHLL-ES---PEVGQFI-----------------------------TryP---VAGD--NRIEKgyPAYTPt--- 1044
Q3SKA9           941 NQLRCLHLM-DP---DAIGLTP-----------------------------YpfR---GEGD--STVDK--PRYED---- 976  Thiobacill...
Q0ASV4           946 EALRRLHLMEDT----AVGETP-----------------------------YpfL---GDGDpvLEARH--PDFKAt--- 984  Maricaulis...
EFL88046         963 TQLRRLHLMEEAaiGDTPFPFE-----------------------------GeaP---DGED--GSVAK--PQFVEt--- 1003
WP_045576530     985 RYLRQLHLM-ES---PALDNLI-----------------------------TsyP---AGGS--NVVEN--PIYKD---- 1020 Desulfospo...
EIJ35287         947 NELRQVHLL-ES---VLLNKAI-----------------------------TsyP---KVGD--NTVTR--KILSKdwel 986 
sklmb:Mhar_0139  378 GELVALHLL-ES---PLLARPA-----------------------------TryP---VVGD--NRVEKgyPK--Yfapg 417 
WP_013705746     954 AALTALHLM-EA---PALERLI-----------------------------TtfP---VPGS--NIVEK--VEYVAqaps 993  Desulfobac...
WP_015083613     950 DKLVKYHLMKET---G---TEI-----------------------------StyP---IPGS--DIVEQ--VKYNE---- 983  Anabaena s...
BAM32310         777 ------------------KGVKDSILLNDT-----IAIVDIPHKAYAYKVNG-KSAIE-WILDRYKISTDKASGIVNDPN 831 
GAK59511        1045 -----------------kGEQAGRVKINAA-----QYFEGVPPEVWEFYIGGyQPAQK-WLKDRRGRQLSYD-----DLS 1096
Q3SKA9           977 ----------------------GKVWVNET-----QYFDTTPEAAWGFYIGGyQPAQK-WLKDRKGRALSFD-----DVK 1023 Thiobacill...
Q0ASV4           985 ------------------KDGLGDVWINKS-----QRFTNVPEIAWGFPIGGyQPAQK-WLKDRKGRTLGFDD-IRHYQK 1039 Maricaulis...
EFL88046        1004 ------------------GKGTGLVAINGTasspgQHFQNVPKIAWEFFIGGyQPAQK-WLKDRKGRTLSFDD-IRHYQK 1063
WP_045576530    1021 ----------------------GAIFINKDg----QGFFGVPQVAWEFYIGGyQPAQK-WLKDRKGMAVTKDDILHYQKI 1073 Desulfospo...
EIJ35287         987 ---------------ydvDRSLGRIWINDE-----QYFDQIPLLAWEFYIGGyQPAQK-WLKDRTGRVLTRDD-----IR 1040
sklmb:Mhar_0139  418 egep------gskagdgaVLEVGRVYINRS-----QYFEGVPPQVWEFQVGG-YQVCDkWLKDRRGRQLSYDDLTVYQKV 485 
WP_013705746     994 pvlgspstvqqgaaeaavPPMSGRVFINAE-----QYVAGVSPKVWAFQVGG-YQVLHqWLKDRKGRALSFE-EIHHYQK 1066 Desulfobac...
WP_015083613     984 --------------------NHQQIWINSE-----QYFDQVPQQIWNFYIGG-YQVCQkWLKDRKGRELNFD-DISHYQN 1036 Anabaena s...
BAM32310         832 LYEstsgalkglKGGRYVLEL 852 
GAK59511        1097 HYQkiv---aalHKTGELMQR 1114
Q3SKA9          1024 HYQril---kilSETDRIMRT 1041 Thiobacillus denitrificans ATCC 25259
Q0ASV4          1040 IIKi-------lAETDRIMKE 1053 Maricaulis maris MCS10
EFL88046        1064 IIKi-------lSETDRIMKT 1077
WP_045576530    1074 IVAl--------TETDRIMKE 1086 Desulfosporosinus sp. I2
EIJ35287        1041 HYQkii---valKETDRLMQE 1058
sklmb:Mhar_0139  486 VVAl--------KETIRLMEE 498 
WP_013705746    1067 IVAa-------lTETIRLMGE 1080 Desulfobacca acetoxidans
WP_015083613    1037 IISi-------iSETVKIMED 1050 Anabaena sp. 90
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