1D2T,1IDU,1QHB,1QI9


Conserved Protein Domain Family
PAP2_like
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cd01610: PAP2_like 
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PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.
Links
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Statistics
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PSSM-Id: 238813
Aligned: 626 rows
Threshold Bit Score: 31.6619
Created: 13-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1D2T_A: bound sulfate marks the phosphate binding site of Escherichia blattae non-specific acid phosphatase
  • Structure:1IDU_A: Curvularia inaequalis, chloroperoxidase, vanadate is bound at the active site
  • Citation:PMID 9165086
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             #      #                         ###                      
1D2T_A       93 PALHKLLTNMIEDAGdlaTRSAKDhYMRIRPfafygvstcntteqdklskngSYPSGHTSIGWATALVLAEInp------ 166 Escherichia blattae
NP_347925   130 SNPYMIFVILVIVCIl--TLIIKAiFGEGTPlr------------------gGMPSGHSTIAFSLATIITLIspq----- 184 Clostridium acet...
BAB81723    130 TEPYIIFIVLAIVCIv--VVAAKAyFGEGTPlk------------------gGMPSGHSAIAFSIATAISLIsns----- 184 Clostridium perf...
AAM24228    130 SPIHVTVISILVVVFl--TLILKVyFKKGTPmr------------------gGMPSAHSAIAFSVATAITFMtan----- 184 Thermoanaerobact...
NP_953332   162 PTEMGTVVALLVVVIv--VVILKSlSGRGTPle------------------gGLPSGHAAVAFGIATVVSLStqd----- 216 Geobacter sulfur...
XP_771452    40 FDKTLLAVGCVMLTNpavSYALKHlLHQPRPcsp----------------dpGMPSAHAFWAAGLSAALFLAahsqcsrs 103 Giardia lamblia ...
ZP_00678048 104 SADMGTMVSVLIVIIv--VIMIKSlTHKGTAle------------------gGIPSGHAAVAFSIATAVSLNtqd----- 158 Pelobacter propi...
ABA88483    133 PPGELAILSLLTVILl--VVLLKAwAGRGTPle------------------gGMPSGHAAFAFSVATSVALAavg----- 187 Pelobacter carbi...
ZP_00802611 130 SPLHVTFITLIIVIFv--TIALKAyFGRGTPlq------------------gGMPSGHGAISFALATSITFIsen----- 184 Alkaliphilus met...
ZP_00884832 131 ISFHVVFLSLIIVAMv--IVVVKAvNKRTKFmq------------------gGMPSGHTALAFAAATAIIMLtnn----- 185 Caldicellulosiru...

Feature 1                                   #     #   #                
1D2T_A      167 ------------qrQNEILKRGYELGQSRVICGYHWQSDVdAARVVGSAVVATLH 209 Escherichia blattae
NP_347925   185 -----------pvvIILSYFLAVIVAQSRVDSKVHSSLEVvCGAVFGFLATLLLF 228 Clostridium acetobutylicum ATCC 824
BAB81723    185 -----------hiiIILSYLMALITAQSRVDSEVHSVWEViAGAILGTLITILIF 228 Clostridium perfringens str. 13
AAM24228    185 -----------afiSTLSFLLALMVAESRVEGKIHTFSQVfVGAILGILFTVLIF 228 Thermoanaerobacter tengcongensis MB4
NP_953332   217 -----------pliSILTIALAVMVSHSRLLLNIHTMREVvLGAITGTAISALVL 260 Geobacter sulfurreducens PCA
XP_771452   104 lsasttklaalrlyAYAACFTTPLVAAERIYSREHTIAQVaVGLPLGALYTLLVW 158 Giardia lamblia ATCC 50803
ZP_00678048 159 -----------pliSLLCVTLAAMVSHSRLLMRIHTMREItIGSLVGAGITAIVL 202 Pelobacter propionicus DSM 2379
ABA88483    188 -----------svvTLLVLALAVMIGHSRVYMGIHSLHEVlAGALLGAGVTWALF 231 Pelobacter carbinolicus DSM 2380
ZP_00802611 185 -----------mfiGTLSILMALLVCQSRIEGKIHTFFEViMGAILGILITVIIF 228 Alkaliphilus metalliredigenes QYMF
ZP_00884832 186 -----------liiVSLAVFMAFLVLESRIEAKIHTIWEAvVGAVIGVLVTLLIF 229 Caldicellulosiruptor saccharolyticus DSM ...

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