Conserved Protein Domain Family
E3_UbLigase_RBR

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pfam18091: E3_UbLigase_RBR 
E3 Ubiquitin Ligase RBR C-terminal domain
This is the C-terminal domain of HOIP present in Homo sapiens. HOIP synthesize the linear ubiquitin chains that help control innate immunity and inflammation. This region has an RBR domain which catalyzes the transfer of ubiquitin onto a substrate.
Statistics
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PSSM-Id: 436265
Aligned: 9 rows
Threshold Bit Score: 132.112
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011616027  552 SRLHLLLQHYRVsp-tCLEASEGSSpasCCTGT----CSVLELRDD-S-SRQEEACGRAALPGHRGYCEVHYKERLVELV 624 
XP_007565109  985 DRLQALLQRSGV----AFNTDPSNE---TPTDA----CGVMEQKDEgG-QPADSPCGLQTQPGQAGLCMKHYREYLVSLI 1052
XP_015210350  627 KRLQQLLRNYNI----PYSLENRAEdkrSSTGM----CTVLEHKETsD-GVVEEQCGRRAPVLYSGYCKLHYKEYLVELI 697 
XP_696033     695 PRLRTLLQRYGVshplMFSPKHPMGrh--sKGI----CGVMEFQET-G-AVKEEACGRQAFPEYSGYCTLHYKEVLVELI 766 
XP_009860551 1199 ERLQKILQDGGI----PHRTECT-----ISNNT----CQVMEQQETpD-GLIDACCGGEVHENNADLCEVHYKEYLVILI 1264
KOX78046     3486 AQLQQLLKDNGI----GYDTEGPAGe-----rK----CKVQLQKETpT-GVVDAVCNSDVVEGHAGLCRIHYIEYLVRKI 3551
KDR18370     2098 TQLQTLLKEHNI----SFDTELPPNlktQEQNGeklkCLVQLQRETpA-GVIDTVCKEDIAEGQAGLCRLHYIEYLVGLI 2172
XP_014786196 1148 QELQKLLQMSHV----NFDTESKEQv-----DV----CPVIEQKEIsSdTFKDAKCGKCVSPNNAGFCTDHYKEYLITLI 1214
EKC32576     1573 EELQRLLKEKNV----KFDTEAPEHq--eDQRH----CPVMELKDVhE-GKKDEACGKDVIAGHAGLCGSHYKEYLVNLI 1641
XP_011616027  625 NHFGCDPVILFSPGEMRAELQR 646 
XP_007565109 1053 NDHSLDPAVLYETQELVVACQR 1074
XP_015210350  698 NNHSLDPAVMFTIDEIATELQR 719 
XP_696033     767 NSNGLDPVVLLDGAELRAEMDR 788 
XP_009860551 1265 NKNHLDPATVFTGDELETCLHR 1286
KOX78046     3552 RETQLEPLPLLNIDDLETCVKR 3573
KDR18370     2173 ARHKVDPISIFDLTDVQQELRR 2194
XP_014786196 1215 NENKVDPIELFTKQNIIQVLSR 1236
EKC32576     1642 NRNKVDPVYIMDVSEMIRLIER 1663
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