Conserved Protein Domain Family
PRK08199

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PRK08199: PRK08199 
thiamine pyrophosphate protein; Validated
Statistics
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PSSM-Id: 181285
Aligned: 111 rows
Threshold Bit Score: 804.094
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
187928317   9 ASLVVEPR----HGG--------------QILVDALLAHGVDMAFGVPGESYLSVLEGFYQRRdrARFIVCRQEGGAANM 70 
85373613    1 -----MTRsttpDAA--------------RLLVDCLVEQGCDRVFTVPGESFLQVLDGLHQHGs-IDVVTCRQEGGVAFM 60 
83591624   19 VQSSVASR----TGG--------------ALLADSLIALGADTVYCVPGESFLPFLDAVHDRTdaLRLVVCRQEGGASYM 80 
83311649    2 SQLSPAPR----TGG--------------EILADALLAQGADTVTCVPGESFLPFLDAAWDRRdrLKVLAFRHEGGAAYA 63 
91781170    1 MTSRTNMR----KGS--------------EILADEFSLNGTDLVYHVPGESFLSALDALAVRHpeVRLIACRHENGAAQM 62 
239825946   1 MKQTIRNT----TAA--------------KAIVHCLKREGISHLFCVPGESYLPLMDAIFDEPs-LQLISARHEGGASFM 61 
56418908    1 MKRTMRHI----TVA--------------QAIVECFKQEQIRYVFGVPGESYLPLLDAIYDEPs-IEFISARHEGGASFM 61 
138894022   1 ------------MGGtamkkrvmrglsvpQAIVECLKQERISHLFGVPGESYLPLLDALYDEPt-LQFISARHEGGAAFM 67 
212639080   1 -----------mNAA--------------EAIVQCLKSEDISHVFCVPGESYLPILDALFSEKt-IQLISARHEGGAAFM 54 
261418702   1 MKRTMRHI----TVA--------------QAIVECFKQEQIRYVFGVPGESYLPLLDAIYDEPs-IEFISARHEGGASFM 61 
187928317  71 ADAYGKLTGRPGIVFCTRGPGATNASIGVHTAFQDSTPLILFIGQVGRDFVDREAFQEIDYRRMFGQMAKWVAQIDSVER 150
85373613   61 ACADGAMTNRPGVAFVTRGPGATNASIGVHVALQDSQPMILFVGDVGRDMREREGFQEIDFLAFFGPIAKWAARIDSADR 140
83591624   81 ADAHAKMTGKPGVCFVTRGPGACNAAIGVHTAFQDCTPMLLFIGQVDRPMIGREAFQEVDMTAFFAPLAKFSATADSAAR 160
83311649   64 AEAHGKLTGRPGVCIVGRGPGATHASVGVHTAFQDSTPMVLLIGQVDRPIRGREAFQEVELAQMFRPLAKRVEEITSPDR 143
91781170   63 AEAYGKLTARPGIAFVTRSPGATNAVNGVHTAFQDASPMILVVGQVKRALMEREAFMSYDFRAMFAPMAKWVAQIDCAAR 142
239825946  62 AEGYAKASGKPGVVLATRGVGGANLAIGVHTARQDSTPMVVFLGQVHSHFRGREGFQEVDLDRFFQPIAKWTVEIREAER 141
56418908   62 AEGYAKASRKCGVVLATRAVGGANLTIGVHTARQDSTPMVVFLGQVNSRFLGREGFQEVDMEAFFRPIAKWVVEIREAER 141
138894022  68 AEAYAKASGKPGVVLATRGVGASNLAIGVHTARQDSTPLVVLLGQVHRRFRGREGFQEVELDEWFRPLAKWAVEITDPER 147
212639080  55 AEGYAKASKKVGVVMATRGVGATNAAIGIHTARQDSTPMVVLLGQVARSFRGREGFQEIDVEACFRPLAKWAVEIDDAQR 134
261418702  62 AEGYAKASRKCGVVLATRAVGGANLTIGVHTARQDSTPMVVFLGQVNSRFLGREGFQEVDMEAFFRPIAKWVVEIREAER 141
187928317 151 IPEYIARAFQTATAGRPGPVVLALPEDMLTD-VATVADVPPevatKARAMAWPSPHDLARLKTLLQDAERPMLLLGGSGW 229
85373613  141 IPEFVARAYSVAMSGRPGPVVLALPEDMLSD-TTTARPRPQ----VARPAQAVCPDAMQAMMAMIGDAASPVAIIGGAGW 215
83591624  161 LPELVARAWAAATSGRPGPAVVALPEDVLAE-MAFARDPLP----RPPARPAPRAADMADLASRLAAAERPLVIVGGGTW 235
83311649  144 LPEAVARAFAAAMGGRPGPAVLILPEDMLAE-RASVADVER----LPPALPHPGPCRLDKMVELLAKARRPLMLVGGGGW 218
91781170  143 IPEFVQRAYHTAMTGRMGPVVLILPEDVLEEeSDVAPGKRY----VRARAGEPSSSQVDSIFGMLAEAARPLLVVGGSGW 218
239825946 142 IPELVQRAFRIAKTGRPGPVVISLPEDIFLQ-DIAEAVISN----VDIPRPAPSTEDVRSVQEILQRAKRPVVIAGGGVK 216
56418908  142 VPELVQRAFRTAKTGRPGPVVVSLPEDVFSK-TITEAVMAE----TYVPKPAPRQEDIRNIKERLERAKRPLVIAGGGVK 216
138894022 148 VPELVQRAFRVAKTGRPGPVVVSIPEDVFAS-TVAEAVLMT----MDVPRPAPADDEVKRIEAALAAARRPLIVAGGGVK 222
212639080 135 LPELLTRAFRIAQTGRPGPVVVALPEDVLHE-QVDHVTFSK----TIVPKPAPNEEDIQRIEQLLRSARRPVVIAGGGII 209
261418702 142 VPELVQRAFRTAKTGRPGPVVVSLPEDVFSK-TITEAVMAE----TYVPKPAPRQEDIRNIKERLERAKRPLVIAGGGVK 216
187928317 230 TPQAAARMQAFAERWNLPAGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVKDADVVLAIGTRLGEMTT------SGYT 303
85373613  216 HSKAREHFQLFAERIGLPVATAFRRQDAISPASPVYAGNLGYGPNPKLVERVRNADLILAVGARLGEATT------EGYT 289
83591624  236 TPRAAKLVTTWAEASGLPVVAAFRRQDVVDNLSPVYIGELGFSASPRLNARIKAADLIVCVGDRLGEVTT------QGYS 309
83311649  219 TPEAARLITAFAEGWSLPVAACFRRQDIVDNESACYGGELGYSMAPSLGARVREADLILAVGTRLGDIDT------AGYS 292
91781170  219 TERARDDIQAFAQANGVPVVTTFRRRDIIDHRLPVYAGEIGIGSNPALLTHVREADFVLMCNDALSDVNTigagymEGFT 298
239825946 217 LAKAEQLLRLFAEKYSIPVAAAFRRHDVFPNDHPLYVGHLGLGTPKSIIETVKQADVVIAIGTRLSEVTT------QDYR 290
56418908  217 WSGAEQLLRLWAEKYALPVMAAFRRHDVFPHNHPCYVGHLGLGTPKEVMETAEQADVVIALGTRLSEVTT------QDYR 290
138894022 223 RGRAEQALRRVAEQYSLPVVAAFRRHDVFPHDHPLYVGHLGLGAPAAVVETAKQADVILAVGTRLAEVTT------QDYT 296
212639080 210 WSKAIDVLRLFAEKWSLPVMSSFRRHDVFPNDHPLYVGHLGLGTQRAIIETVEQADVVLAIGTRLSEVTT------QDYK 283
261418702 217 WSGAEQLLRLWAEKYALPVMAAFRRHDVFPHNHPCYVGHLGLGAPKAVIETAEQADVVIALGTRLSEVTT------QDYR 290
187928317 304 LFDVPRPKQTLVHVHAGAEELGRVYQADLMIHASMPAIAEALDGVSPDAPPRWSAWTEAANADYRANIVpPPFGGKGIDM 383
85373613  290 LITPDHPDQMLIHVHPDPDELGSVYRTDLSLCADMGEFAEAAALWEENS-VISFDAGAEAHAEWEAWAT-ATPGDWQLDL 367
83591624  310 LIESPVPSQSLIHIFPDAGEIGRVYATDLGIVSAMEPFAEMLSPVDGRH---WAGWLAQGRADYAANLR-ADPCPGSVDM 385
83311649  293 LIEAPNPKQILIHVFPEAEELGRVFRPDLAIVSAMLPFARRASQLAAPAALPWTDWTRAVRGDHLANRV-PNSCPGALDM 371
91781170  299 LFDIPVPRQRFVHVTGNFDDLNRVHQVDLAILADNDAFAAALSRHEAVDASRRTEWLARLRSSFEIETA-PSPCAGPIDL 377
239825946 291 LLS---SDQTLIHIDIDSDVLGKVYPPDISILADCKETLLKLLKIv--vQPSWRDWVAARRKQYEQVS--ILPVEKRNLN 363
56418908  291 LLS---PTQTLIHIDIDSDGLGKVYAPDIAVWADCREALSRLLDIa--vQPSWQEWAAERRERYEQTA--ALPLEKRTLH 363
138894022 297 W---PLPHQMLIHIDIDEEALGKVFSADIAVAADAHEALCALLGRh--iVPTWNEWVLERRQAYEETA--RLPQPPRNVQ 369
212639080 284 LLS----TQQLIHIDIDYDVIGVTYSPHIGVVSDAKEALSRLLNIq--lHPSWTDWVKERRKTYERFS--SLPSMKRNVN 355
261418702 291 LLS---PNQTLIHIDIDSDGFGKVYAPDIAVWADCQEVLSRLLDIa--vQPSWQEWAAERRERYEQTA--ALPLEKRTLH 363
187928317 384 ARAMQWLRERLPRHSILTNGAGNYATWLHRFYQYGALaagsRTQLAPTSGAMGYGAPAAVAAKIVSPDTPVICMAGDGCF 463
85373613  368 ARCVTFMRDTLPADTIICNGAGNFAGWWHRYWRYRGH----PTQLAPTCGAMGYGVPAAVAAARRFPNRTVVAIAGDGDF 443
83591624  386 AQVMAEIEARLPEDAVITNGAGNYSGWVHRFHRYRHF----PSQLAPGNGSMGYGLPAAIAAKVVAPRRVVVAFAGDGCF 461
83311649  372 GQVMAEIEARLPEDAIICTGAGNYTGWPQRFHRFRRY----PGQLAPANGSMGYGLPAALAAKALYPDRAVVAFAGDGCF 447
91781170  378 PRVMQWLRERLPDDAIVTNGVGAYATWSQRYFPHYRL----HTQLGPISGSMGYSLPAAISAKLLYPERVVVDVVGDGCF 453
239825946 364 EAIIASLQEHLPNNSIITNDAGNFAGWLHAFFQFTEE----HTYIGPTSGAMGYGMPAAIGAKLAFPERVVVSLSGDGGF 439
56418908  364 EAVMASLGHHLPKNAVITNDAGNFAGWLHAFFPFGDG----HTYIGPTSGAMGYGMPAAIGAKLAFPDRTVVSLSGDGGF 439
138894022 370 EAIIAQLQAQLPDDGMITNDAGNFAGWLHTFFSFKEQ----HMYIGPTSGAMGYGLPAAIGAKLAHPERPAVSLSGDGGF 445
212639080 356 EEMIHILQHLLPSEAIITNDAGNFASWLHSFFQFQQ-----HTYIGPTSGAMGYGLPAAIGAKLANPHRPVVSLSGDGGF 430
261418702 364 EAVMASLGRHLPKNAVITNDAGNFAGWLHAFFPFGDG----HTYIGPTSGAMGYGMPAAIGAKLAFPDRTVVSLSGDGGF 439
187928317 464 LMNGQELATAMQYNAPVIFIVVNNGMYGTIRMHQEREYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEGFQSAVETAL 543
85373613  444 LMNGQELATAAQYSLNLMVIIVDNGAYGTIRMHQEREFPERISATELKNPDFAALAESYGGWSARAKTTDEFKTGLVEAE 523
83591624  462 LMNGQELATAVDQGLDPIIIVINNGMYGTIRMHQEKAYPGRVSGTSLTNPDFVALAQAYGALGLRVRRTAEFGPAFDQAL 541
83311649  448 LMTAQELATAKLHGLSPVVLVVDNGMYGTIRMHQEASHPGRTLATDLANPDFAALAAAYDAWTARVERTEDFAPAFDQAL 527
91781170  454 QMSGEELATAVQYGVNIVVVIFNNSMYGTIRIHEENRLSGRRHGTDLVNPDFAALARAYGAHAEKVVATGEFGPAFERSL 533
239825946 440 MMTVQELETAARYEIPIISVVFNNRMYGTIRMHQELHFPKRVIGTDLGNVSFAELAKCLNGNGIQVETEQQFTETLLQSL 519
56418908  440 MMTVQELETAARYDIPIISIVFNNHMYGTIRMHQELQFPGRVIGTDLGRVSFARLAECLNSCGFQVQTEQQFTEALLLAL 519
138894022 446 LMTAAELETASRYGVPVISLVFNNRMYGTIRMYQELQFPGRVVGSGLGEVSFARLARALGANGVTVETADEFAAAFKQAL 525
212639080 431 MMTIQELETAVRYNIPIISVVFNNQMYGTIRMYQELRYPKRVIGTDFSNISFASIARCFGTDSMRVETGEQFSSAFTTAL 510
261418702 440 MMTVQELETAARYDIPIISIVFNNHMYGTIRMHQELQFPGRVIGTDLGRVSFARLAECLNGRGFQVQTEQQFTEALLLAL 519
187928317 544 AALVASIIEVQTDPNII-SPRATIDSLHAQSRS 575
85373613  524 GRSGLRLIHCLIDVEQLaASGATISGLRSR--- 553
83591624  542 VAGRPVLIEIHQDPEAI-SHRVSLTALREKALA 573
83311649  528 AAGRLALLHLVLDPEAI-TTRTTLTAIRDKAQN 559
91781170  534 AAGKPAVIELLVDPEAI-HTRYSLSDLRKRREA 565
239825946 520 HAKKPTVIEVLTDPNQI-SVTATIAELRKRSNS 551
56418908  520 EAKKPTVIEVLTDPNHI-SVAATIQDLRAKRKS 551
138894022 526 TATKPTVIEVMTEPEQL-SVTMRLSDR------ 551
212639080 511 QNNKPTVIEVMTDPNIL-SPFLTIEQARGGKQ- 541
261418702 520 EAKKPTVIEVLTDPDHI-SVAATIQDLRAKRKS 551
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