3KYJ,6S1K,7C1I,2A0B,1WN0,4EUK,1C03


Conserved Protein Domain Family
Hpt
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pfam01627: Hpt 
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Hpt domain
The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to contain a binding surface for Ssk1p (response regulator receiver domain containing protein pfam00072).
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Statistics
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PSSM-Id: 426352
Aligned: 229 rows
Threshold Bit Score: 32.7079
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3KYJ_A         11 EIWALYADDGAQALDAMEASLlalqagedAAAHVGPLFRAVHTFKGNSRVLGLSVVESRAHLCEDliglvrdAGVPMDGE 90   Cereibacter s...
Q9KPJ8        689 DSVHLFEQSMPAYLAVLDSNM--------VAKDQEGIVSEAHKIKGAAGSVGLKRIQKIAQKAQS-------PEAPAWWE 753  Vibrio cholerae
3_pfamImport    1 DSIRMFEEMMPEYLEILDSNM--------IAKDQPGIVSEAHKIKGAAGSIGLKRIQSVAQKAQS-------PDMPAWWE 65  
Q9CNW0        521 KNLALFKETMPEYMQALMTAYsvy---qqDESQKADVLSCAHKIKGAAASVGLKRIQQIAAQAQD-------PEQGEWTE 590  Pasteurella m...
Q8EHA2         29 KSVVLFEQLMPEYVGNLVKAN--------EAADKDTLCSEAHKFKGAAGSVGLKRIQQIAQLLQH-------GEEADWES 93   Shewanella on...
2A0B_A         31 DGLAVFEKMMPGYVSVLESNL--------TAQDKKGIVEEGHKIKGAAGSVGLRHLQQLGQQIQS-------PDLPAWED 95   Escherichia coli
Q7N085        687 NSLSVFEKMMPGYLSVLDSNM--------TAKDQKGITEEAHKIKGAAGSVGLRHLQQLAQQIQS-------PDLPAWWD 751  Photorhabdus ...
Q847W1       1133 EIARVFSQSMAMDIENLQAAP-----------TERDKKRVIHGIKGAVGAIGISMLTELCIEAER-------VTAAEFDR 1194 Vibrio paraha...
Q7UZ66        903 AIVSDFIVRLDQRLVDMRNEL--------RDQRFDALELSAHWLKGAGGTVGYGDLTQPSRDLID-------AALAANPA 967  Pirellula sp.
Q7UZ66        777 AIAGDFVSRLHTRLDGIEQAI--------QESKFDFVHGEAHWLKGAGGTVGLDVFTEPARTLEQ-------AAKDGSPD 841  Pirellula sp.

3KYJ_A         91 IVEillf-asdTLRAMLEETAAS 112  Cereibacter sphaeroides
Q9KPJ8        754 NISdwveeiknEYQSDIALLKRW 776  Vibrio cholerae
3_pfamImport   66 NIAdwveeiknEYQNDIQILKSW 88  
Q9CNW0        591 NIHdwvqqlaqYWLLDVEALERY 613  Pasteurella multocida
Q8EHA2         94 KHAtwvaqiveFASADLQQLKQF 116  Shewanella oneidensis
2A0B_A         96 NVGewieemkeEWRHDVEVLKAW 118  Escherichia coli
Q7N085        752 NVQewvdelkqEWRKDTEILGEW 774  Photorhabdus laumondii subsp. laumondii
Q847W1       1195 RAAel----ilRIEQEIDNIDYW 1213 Vibrio parahaemolyticus
Q7UZ66        968 DCE--------TYLSQIESVRAR 982  Pirellula sp.
Q7UZ66        842 IAQ--------SILNDIRELHGR 856  Pirellula sp.
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