2QPQ


Conserved Protein Domain Family
PBP2_Bug27
?
cd13578: PBP2_Bug27 
Click on image for an interactive view with Cn3D
Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold.
Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.
Links
?
Statistics
?
PSSM-Id: 270296
Aligned: 84 rows
Threshold Bit Score: 333.316
Created: 9-Mar-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
chemical
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding site [chemical binding site]
Evidence:
  • Structure:2QPQ; Bordetella pertussis Bug27 with bound citric acid, contacts at 4A.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #   ###                                                              
2QPQ_A         5 FPNKPLDIIVTFppGGGTDMLARLIGNYLte-sLGQTAVVENRPGASGNVGARLVADrapDGYSLLMVnsSFAVNPGVfr 83  Bordetella pert...
NP_883716     27 FPERALRVVVPYppGGTTDVLVRLLQKPVad-aAGQSVVVDNRPGGASVIGTSHVAQaapDGYTVLGGdlSMLVNPSLmk 105 Bordetella para...
NP_887084     30 FPAQPITLVVPYppGGTADSLARVLAKSMga-rLGVNMIVLNKGGAGTVVGTQFVANsaaDGYTLLFTatPFAINPSLfe 108 Bordetella bron...
NP_891200     34 PSDQPLRIVVPYapGGTGDVIARLVAKKLge-qSGQSVVVENKPGAAGSIGASTVARaaaDGNTLLLGytSEMVINPIvq 112 Bordetella bron...
YP_553412     42 YPDHPIRLVVGYtpGGGADIMARLLQKQLtt-tLKQSVIVENRPGAGQNIADAYVAKaspDGYTLLVSssALAVNPSLfp 120 Burkholderia xe...
YP_553415     30 YPSRPIRMIVPFvpGGASDNLARALAAELtr-kLGQNAIIENKPGAGTVIGSQYVAHaepDGYTLLWAtaPLAINASLmk 108 Burkholderia xe...
YP_995324     28 FPDRPMRIIVPFavGGNTDVLARLFSQKLga-lLKTSITVENKTGSGSVLGTDAVAKapaDGYTLLLGtsSHAINAALyp 106 Verminephrobact...
YP_001353542  27 YPSRPIRLVVPYapGGSADIVARRISDEWsk-aLGGSIYIENKAGAGGNIGVDAVAKadaDGYTIGLQtvSLAINPSIfp 105 Janthinobacteri...
YP_001564162  30 QNGTPLRVILPVgaGSGADTIVRSAQTALvrslGGQPVVMENLPGAGGITGTQMLVKapaDGNTIAFIsnNHAVNPSVfk 109 Delftia acidovo...
YP_001566746  46 WPAQPVRIVVPYtaGGGSDNIARALGTELsr-eLGQPVVVDNKPGASAMLGAELVARaapDGYTLLLAdmPHTITPSLyk 124 Delftia acidovo...

Feature 1                                                                  ##                    
2QPQ_A        84 nlp-fdpkKDFAAVINVaYVPSVFVVPagskyktLGELMAAAKqtntqVTYGSCgngtPQHLAGELLNVSAKTHMVHVPY 162 Bordetella pert...
NP_883716    106 dlp-ydtlRDFRGVTMLaRAPLVLLVHpsvpantLDELIALAKarpgtLNFASGgygtSTHMAGEMFRRAAGIDVVHVPY 184 Bordetella para...
NP_887084    109 klp-ydtlKDFTVVSDIaETPLVVAAGsgtsintLGELVDRLKtg-kdNSYGSAgpgsSPHLVSELLLHEVNGEATHIPY 186 Bordetella bron...
NP_891200    113 kgvsydvaRDFAPVAMAgSTPLLLVANptvgansIAELVALAKarpnrLSYASAgpgsPAHIAGALLAREAGIQLLHVPY 192 Bordetella bron...
YP_553412    121 kls-qnplTAYAPVALFaQSPNLLVVNpklpvnsVAELIAYEKkkpdgGNFSSSgsgsTQHLSGEIFKLKTGIKATHVPY 199 Burkholderia xe...
YP_553415    109 hlp-ydtlKDLVAVVDVaSSPEVLVVSksrnistLAQLIDSAKknpgkLTYGSSgiggSPHLATVMFANDADIKLTHVPY 187 Burkholderia xe...
YP_995324    107 klp-ydsrKDFAFISMIaQVPMVLSVHprvpatnPKELIALLRanpgkYSFASSgnggSLHMAVELLKFQEQFDALHIPY 185 Verminephrobact...
YP_001353542 106 kmp-ydtlKDLAQISTVaTSQHVLVVNtnfpaknTKDLVALAKanpgkYNYGSAgsgsTFHMSAELFKSVAGIDVTHVPY 184 Janthinobacteri...
YP_001564162 110 klp-ydslADITPLSIVgGSPFVLVVHpkvaarnARELQALMKarpgdLNYASSgngtIFHLAAEVFLDAAGTTARHIPY 188 Delftia acidovo...
YP_001566746 125 tp--ydalKDFTPVALIgSSPLVLAVNpklkaqsVKEYIAMARarpgqINFASGgtgtATHLAGELFKQQTDTFITHIPY 202 Delftia acidovo...

Feature 1                            #                                            #              
2QPQ_A       163 KGcgPALNDVLGSqiGLAVVTasSAIPFIkagKLQALAVTskERSAlLPEVPTVAEqgvaGYELNQWHGLLVPGATPmAV 242 Bordetella pert...
NP_883716    185 QGvaPAMSALLGGqvQMYFGGttTGLPHIqsgKLRALAVTgeAPSPlLPEVPTFVSrgiqGVNADTYWGVYAPARTPdAV 264 Bordetella para...
NP_887084    187 QGsmPAVMDLVANrtTFMFDTplLMLPLAkegRLKLLAQTstQRSPlLPTVPTLQEsgypNLSVTSWFVVAARSGAPrDV 266 Bordetella bron...
NP_891200    193 KGgsQAVTDTVGGvvSIYFSGmpPAVPFVkngKLTALGVTarQPSPaLPDVPALAAqdypRLDLAGWFGFFAPREVPaPV 272 Bordetella bron...
YP_553412    200 KGsaPSVAAVMSGdvDFSFVNipSAKPLVlahQLKALAVTsaQRSPlLPDVPTMTQagldGMNIAAWYGLLAPAGTPaPV 279 Burkholderia xe...
YP_553415    188 QGsaPAVTAAMSGqvDMVIDTflTCLPGItagTLVPLAQTetKRSSlLPNVPTMQEagmkGYQASAWFSLLAPSRVPkPI 267 Burkholderia xe...
YP_995324    186 RGagPALTDTVAGqvDFIIDPvtTSAPFVksgKLRALAVTtaQRSPvLPDLPTMQEagfpNYETSTWNLLMAPAGTPaPV 265 Verminephrobact...
YP_001353542 185 KGggPAMIDTISGqvDMCFPVlsAAAPHVkagKLNAIGVTgsKRSPlMPDVPTLAEsgvpGYSFETWFIVFAPAATPkPL 264 Janthinobacteri...
YP_001564162 189 KGvgQMVVDLLSGqvDFGVIAvgTAQAHLksgALRAIGIMgrERVAsLPDVPTVAEqgfpGVDIAGWVAAIGPKGMPpAQ 268 Delftia acidovo...
YP_001566746 203 KGsgQAVADVVAGhtESMFSSapTVIPHIksgALRALATTgaQRSPaLPQVPTMAEsgvrGLTVLHWFGLLAPARLPpGI 282 Delftia acidovo...

Feature 1                                                             
2QPQ_A       243 RQKLYDGIAKVMQrDDVQKKLADlGYSTAsdgPEVFQKMVETDIDRFSALTKQ 295 Bordetella pertussis
NP_883716    265 IEKLNAYYTGALRdPAVQQRTRDlGLTLIgnsAAEHTAQMKTMIGDWGAFVKE 317 Bordetella parapertussis 12822
NP_887084    267 LEKLNSAINAALAdPVVAGAYEAqGMIKTggtLDKAQAKLQQEVKNWALAVQV 319 Bordetella bronchiseptica RB50
NP_891200    273 QAALHDRITAALAaDDIRQALAVqGVETRpmsAQAFGDFVAAEQKKYARFIDE 325 Bordetella bronchiseptica RB50
YP_553412    280 IAKLNAAVNQAVGsEPLKSQFVNlGSDPTvqsSAYFSQYLADDTHRWADAVKA 332 Burkholderia xenovorans LB400
YP_553415    268 IEKLNKAVNEIIQqPKFQQLFAKqGIDMVggaADAAEAHLRGEVKRWQTAVKE 320 Burkholderia xenovorans LB400
YP_995324    266 ITRLSAALHSIAQdADFTRRLVDmGVIPLhmtPSETRRHVERETGQWARVIQS 318 Verminephrobacter eiseniae EF01-2
YP_001353542 265 IDKLNASLVKALNtPALKERMIKeGFDPEtstPAEAKAKLTKELALWAKLVKE 317 Janthinobacterium sp. Marseille
YP_001564162 269 VRRLHDGIATAFAdPEVKAGFARrDEYTVlnsPEAAAQFLRSEQERFARLVKK 321 Delftia acidovorans SPH-1
YP_001566746 283 QTALHDAVARAMAtPALQAKLQSlGLELTprtAAEFGAQMETDAARWARVIKE 335 Delftia acidovorans SPH-1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap