3DOD


Conserved Protein Domain Family
bioA

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TIGR00508: bioA 
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adenosylmethionine-8-amino-7-oxononanoate transaminase
All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]
Statistics
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PSSM-Id: 273109
Aligned: 77 rows
Threshold Bit Score: 537.079
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DOD_A        13 LWLPFTQMkdyDENPLIIESGTGIKVKDINGKEYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQL 92  Bacillus subtilis
ZP_01049449   11 LWHPLTQHq-tARNPIVITRAKGAVMYDDAGNEYIDGIASWYTAMYGHGNEYITSAMHKQMQQLDFVMFSGFTHPPAVTL 89  Dokdonia dongha...
ZP_01201128   14 IWHPLTQHk-tANSPLAIKKGQGNYLYDMSNKPYFDAISSWYTCSYGHANPVLTESIKKQVDQLHHVVFAGMTHEPAAHL 92  Flavobacteria b...
ZP_03970032   13 NWHPYTQMk-gAEDIIPIVRGNGAYLYDDKGNRYIDAVSSWWVTLHGHAHPYIAKRVSEQLLTLEQVIFAGFTHEPAIRL 91  Sphingobacteriu...
WP_012778707  10 IWHPFVQHf-cNPTFKKIIKTEGSYLIDENHDKIIDAISSWWVITHGHRHPIIMNAIRSASENYDQIIFSEYTHEPAEQL 88  Candidatus Libe...
WP_012042935   9 IWHPFTQHa-lQPEMTPVARGDGAYLITRDGRRIIDAIASWWVVTHGHCHPPIVRAIQEQAGQLDQVIFAGHTHEPAEQL 87  Bradyrhizobium ...
WP_010913544   7 VWHPFTQHa-lEPAIPEIARTEGAYLYKADGTRILDAISSWWVVTHGHRHPRIIKAIETTASSLVQIIFAGFTHEPAERL 85  Mesorhizobium loti
WP_011097264  14 IWHPFAQPg-lDHKPIHIVRGEGAYLYTQSGTAYLDAISSWWCNLHGHAHPYIAQKISEQAYQLEHVIFSNITHTPAEEL 92  Chlamydophila a...
WP_012022898  11 LWHPYTQHk-tSQTPIAITKAEGALLWDETGKEYIDAIASWWVNPFGHSNKFIADAIYKQLTTLEHVLFGGFTHEPAVKV 89  Flavobacterium ...
WP_012387839  11 TWVPLTIQd-eSETLLNIVSAEKEFVTDSDGNVWIDAISSWWTMIFGHRHPRLLLALQNQLQSLDHVMLAGNIHEPAENL 89  Leptospira biflexa
3DOD_A        93 AETLIDISPKKLTRVFYSDSGAEAMEIALKMAFQYwkniGK-PEKQKFIAMKNGYHGDTIGAVSVGSIELFHHVYGPLMF 171 Bacillus subtilis
ZP_01049449   90 AEKLVEILPSNQEKVFFNDNGSTAVEAAIKMSLQYyhnkGD-K-RDTLIAFEDGFHGDTFGAMSASGLSSYNGPFEDFLL 167 Dokdonia dongha...
ZP_01201128   93 SKKLIGILPDNQQKLFFSENGSTSVEIALKMAFQYhfnrGE-K-RNVVIALENGFHGDTFGAMSASSLSVYNGPFEDFFI 170 Flavobacteria b...
ZP_03970032   92 SENLLRLLPSNQQKVFYTDNGSTAIEVALKMCIQYyynqGL-K-RTKILAFKNSYHGDTFGAMSVSGRGVWTAPFGDMLF 169 Sphingobacteriu...
WP_012778707  89 ARLLIKIAPLGLQYVFFSDSGSTSIEVALKMALGFfnnnNM-P-RNKIVVMEHGYHGDTIGSMSVSMRGAFNNSYEPLLF 166 Candidatus Libe...
WP_012042935  88 AAGLLDLVPPTLAHVFFSDSGATSVEVALKMALGYfrniGE-P-RTRIAVMQHSYHGDTIGTMSVGARGVFNAAYEPLLF 165 Bradyrhizobium ...
WP_010913544  86 AKALVGLAPAGLDWVFYSDSGSTSVEVALKMALGYfrniDA-P-RSRIVVMEHSYHGDTIGTMSVGARGAFNAAYEPLLF 163 Mesorhizobium loti
WP_011097264  93 SQRLTELLPEGLERCFFSDNGACSIEIALKITLQYlynqGR-P-KTRFVSFKHGYHGDTFGAMSIAGPTDINQPFQSLLF 170 Chlamydophila a...
WP_012022898  90 AERLMEILPKNQQKIFFSDNGSTAVEVAIKVALQYffnkNE-K-RTTIIAFENAFHGDTFAAMAASGISFYTQAFQGMFI 167 Flavobacterium ...
WP_012387839  90 SKAILDLTESNFAKVFYSDNGSNAIEISLKLAIQYyqnlPNsKPRSEFLVFSNSYHGDSIGAMNVSGQNYFNRIFSELRF 169 Leptospira biflexa
3DOD_A       172 ESYKAPIPYvyrs-esgDPDEcrdqcLRELAQLLEEHHEEIAALSIESMVQGASGMIVMPEGYLAGVRELCTTYDVLMIV 250 Bacillus subtilis
ZP_01049449  168 KVERIPTPQ----------DDnldevMAMLEGILASN--KCAAFIFEPLVQGAAGMKFHSVAGLDALVKKCREANVLTIA 235 Dokdonia dongha...
ZP_01201128  171 DVQRIPVPT----------DEninevLNLIEELTTQY--QVASFIYEPLVQGAAAMQMHEPAHLDCLLKLFKEKAVLTIA 238 Flavobacteria b...
ZP_03970032  170 EVIFIDVPTet--------------nINTLFATIDQYAHELACFVYEPLVQGAAGMLMHDPEDLSILMEYCRNKGILLIQ 235 Sphingobacteriu...
WP_012778707 167 DVETIPFPH----------HNeeqktLDDLEKHCSTQ--KIAAFLVEPLILGAGGMQTYRPYILKEFMRITKKYDTLLIA 234 Candidatus Libe...
WP_012042935 166 DVAVVPFPA----------EGfeqatLDALAATCER--DRPAAFIVEPLVLGAGGMLMYPAALLREMHRICKASGVLFIA 233 Bradyrhizobium ...
WP_010913544 164 EVDTIPFPAagre----------qetLDRFEAVARDR--RTAALIVEPLVLGAGGMLMYPAWVLAELKKIAETSGTLLIA 231 Mesorhizobium loti
WP_011097264 171 SADTIDPPYygke----------disLQQAKALFST--GEIAGFIYEPILQGTGGMRVYNPEGLDAILALAKHYDVLCIA 238 Chlamydophila a...
WP_012022898 168 DVVRIPVPV----------KGkeqisFDALESAIKNN--NCAGFIFEPLVQGAAGMVMYEPESLTKLIQICKQNKVLTIA 235 Flavobacterium ...
WP_012387839 170 PTKEFPAPNcmncpwgkKPDHcstecLSDLE--LAIKQKDFAGIVIEPLVFGANGMLFYDKKVLVKLRELATYTGTLLIF 247 Leptospira biflexa
3DOD_A       251 DEVATGFGRTGKMFACEHENVQPDLMAAGKGITGGYLPIAVTFATEDIYKAFYDDyenlkTFFHGHSYTGNQLGCAVALE 330 Bacillus subtilis
ZP_01049449  236 DEIMTGFGKTGTVFACDQLDNKPDIMCLSKALTAGMFPLSITSCTQEIFEGFLSDqv-hkGFFHAHTFSAHPVGCAAAIA 314 Dokdonia dongha...
ZP_01201128  239 DEVMTGFGKTGYNFASEAMINKPDMMCLSKALTGGIMPMAITTCTQEVYDAFYDNel-trGFFHGHTYSGNPLGCAVAAA 317 Flavobacteria b...
ZP_03970032  236 DEIFVGFGRTGRLFAADYLSAYPDVMCFSKGLTGGTMPLGLTTCSDVIYEAFYSDdk-kkALFHGHSFTASPLACTAALA 314 Sphingobacteriu...
WP_012778707 235 DEVMTGWGRTGKIFACNHADITPDILCLSKGITGGALPLAATLCSEEIFDSHLSSdk-kkTFFHSSSYTANPIACAAALA 313 Candidatus Libe...
WP_012042935 234 DEVMTGWGRTGTLFACEQAGIAPDIACYAKGLTGGAMPLAVTLCSADIFEAHYSTdr-rrTFFHSSSYTANPIACAAACA 312 Bradyrhizobium ...
WP_010913544 232 DEVMTGWGRTGTMFACEQASISPDILCTSKGLTGGAIPLAATLATDAIFQAHYSEdr-kkTFFHSSSYTANPIACAAALA 310 Mesorhizobium loti
WP_011097264 239 DEILTGFGRTGPLFASEYMKTHPDILCLSKGLTGGFLPLAVTVVREEIYQAFVAKdr-rlAFLHGHTYTGNPLGCAAALA 317 Chlamydophila a...
WP_012022898 236 DEVMTGFGKTGKTFAMDYVSEEPDMICLSKALTGGTIPMAITTFTQDIFDAFYDDdi-nkALFHGHTFTANPTGCAAALA 314 Flavobacterium ...
WP_012387839 248 DEVFTGMGKLGEPFAFQKAGVVPDLLVFAKGLTGGILPLACTLVPKFIYETFRSKdp-ykAFFHAHTMTGNALACSLGYE 326 Leptospira biflexa
3DOD_A       331 NLALFESENIVEQVAEKSKKLHFLLQDlh--aLPHVGDIRqlGFMCGAELVRSketKEPypadrrigYKVSLKMRELGML 408 Bacillus subtilis
ZP_01049449  315 GIEVLQTKEITKSRERINDAHTAFAQTvk--aHHKVNNVRvkGVVIAIDLTIE---MARygn---lrDELYQFFMQRGVA 386 Dokdonia dongha...
ZP_01201128  318 GIDLLTSSAIQKNIEFITQSHQEHIQVyd--tHKAVAAVRscGVILAIDLAIE---MERygs---krNEIFQWFMDHGIF 389 Flavobacteria b...
ZP_03970032  315 SMELLLQECTLENIQRIVLQHERFAATlr--lHPQVEAVRqqGTILALEWRIG---EETsyfs-dmhDKLYPYFLSKGIL 388 Sphingobacteriu...
WP_012778707 314 NLQIWEKEPVIERIKNLERMHADRLSLlk--sNKKFVNIRqmGTIVALDFNVQ---NKGyff--dknAKLKNFFREKKIL 386 Candidatus Libe...
WP_012042935 313 NLALWRQPEAHARISAVAAAQERSVARfr--eDERFSDVRrcGTITALDLHAD---DEGyla--digPKLQAFFRDSDIL 385 Bradyrhizobium ...
WP_010913544 311 NVEIWRDEPVAERVAALSAKQAAGLQRfr--dNPYFTDCRatGTIAALDLRTG---SAGyla--eigPKLRAFFLERGLL 383 Mesorhizobium loti
WP_011097264 318 SLDLTLSPQCKQQREMIETCHKQFQSQyg----sLWQRCDvlGTVLAVDYPTK---SLGyfs--nlrDTLYNFFIENHLI 388 Chlamydophila a...
WP_012022898 315 SIDLLQTAEMQKNIERINLKHLEFQKKie--nHPKVITARtlGVIFAVEIKSD---SEEsyyg-smrTKLYNFFIDNGVV 388 Flavobacterium ...
WP_012387839 327 AITMLNEFG-LTQVKELEKKLKQYAESfqkkmGNSIENVRvmGGIFAFEWKEP---VANdeylnpigKQIRNSLRKFLIL 402 Leptospira biflexa
3DOD_A       409 TRPLGDVIAFLPPLASTAEELSEMVAIMKQAIH 441 Bacillus subtilis
ZP_01049449  387 LRPLGNTIYVLPPYVITDKELARVYTAIQEALD 419 Dokdonia donghaensis MED134
ZP_01201128  390 LRPLGKTIYIVPPFTTTPQELELLYKALLVFLD 422 Flavobacteria bacterium BBFL7
ZP_03970032  389 LRPLGNIIYLVPPYCITDDDLGYIYETILEALD 421 Sphingobacterium spiritivorum ATCC 33300
WP_012778707 387 IRPLGHIMYLMPPYCITATDLDHIYNTINEAVD 419 Candidatus Liberibacter asiaticus
WP_012042935 386 LRPLGHTIYVMPPYCVTAADLEAIYATIDAAVD 418 Bradyrhizobium sp. BTAi1
WP_010913544 384 VRPLGNVLYLLPPYCITGGELDALYDAIEEAAE 416 Mesorhizobium loti
WP_011097264 389 LRPLGHTIYVLPPYCIHEEDLHRIYHYLQEILC 421 Chlamydophila abortus
WP_012022898 389 LRPVGNIVYILPPYIMSNDQLQKIYNTIEEAIE 421 Flavobacterium johnsoniae
WP_012387839 403 LRPLGRTIYITPPYTISDASLEKIFFALETTLL 435 Leptospira biflexa
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