Conserved Protein Domain Family
Commd8
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cd04756: Commd8 
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.
Links
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Statistics
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PSSM-Id: 240104
Aligned: 7 rows
Threshold Bit Score: 223.059
Created: 12-Feb-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_420723  80 RRPEMLQLlekLPPGRALEFLHNIVDGICGRGYPRYQDYSg----VWSLAEWMEVLEETrTYFKTAVGKNVTDEEAVQQM 155 chicken
EAW93034    7 TPLWRLQK---LPAELGPQLLHKIIDGICGRAYPVYQDYHt----VWESEEWMHVLEDIaKFFKAIVGKNLPDEEIFQQL 79  human
AAH84128    7 SGLRLIGK---LPVAQCPQFFHKVIDGVCGRAQPRFQDYGn----IWSLREWLEVLEDSaTFFKNSIGTDVNADEASNGL 79  African clawed frog
XP_700349  10 WPSWDSNL---RPSCYDVTLIHRVVDEVCGRSGPSRSDYSd----RWSLTEWLELMNSLsSLIRFAVGRGCSDQEMQTLL 82  zebrafish
CAF92661    9 SVPECIRV---SNFKAKGKLCHRVVDGLCGQQPPSRAEYSs----TWTLEEWTELNKSLiTLFHLAAHSNSCDEKAVAVL 81  Tetraodon nigrovir...
XP_789228   3 TPIEDLGLlskCSTADMEKLLHQVADSVAGHHRPRYQDYGk----IWSLDEWFQVIQGCeTYLKMAVKKDSTKDEMKAAL 78  purple urchin
EAT33795    1 MHDLLINVakeDDVVQIVHLLIDHLLELPKSALTRSKLASalkivNASSEDLTVTLRLLdNLIRQYCLGEINESELKSHF 80  yellow fever mosquito

XP_420723 156 NELNANYQEAIIKCLKARKEEIRNALVETVNAISSAQLQDFDWQLKLALSSDKISMLQMPLLNLDLDVR-ENGEIKPISI 234 chicken
EAW93034   80 NQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVK-ENGEVKPYSI 158 human
AAH84128   80 NGLSAEHQEIILKCLKSRKPEIEEAVVEKACAMSSAYLQDFDWQLKLALSSDKLSALQMPLVNLDLDIA-KNGSVTPVSV 158 African clawed frog
XP_700349  83 SDLDPTHTEAVLQCVRSRFEEIRRALVDRTNGISSTQLRDFNWQLKLALSSDKLSALNTPLLNLSLDLK-ENGIQRSVNI 161 zebrafish
CAF92661   82 SDVDSSHTKAVLSVLTARREEIHMALINKTNSISFAALQDFDWQLKLAVSSDKMASLHLPLLSLNFTVK-ENGILQPVTM 160 Tetraodon nigrovir...
XP_789228  79 SGLSEDVQERLMECVSIRRDDLGKALIGNTASISQSHLTDFDWKLKLAMSSDKISSVQEPLVNLDLSLM-EDGTNRLVSL 157 purple urchin
EAT33795   81 SNLSSSMQTALVHSVELRKPEICQFLVNKINSKDNLLMESFDWDVKWIMGNSSLASTREQIATVMLNCRdKDQKLKTVRF 160 yellow fever mosquito

XP_420723 235 EMNKEELQNLINALEAANKIVLQL 258 chicken
EAW93034  159 EMSREELQNLIQSLEAANKVFAIL 182 human
AAH84128  159 EMNKEELQNLIHSLEAANKVVLQL 182 African clawed frog
XP_700349 162 EMNKEELQTLISALEAANKVMLKE 185 zebrafish
CAF92661  161 EMDREELNMLISSLDAANKQVASV 184 Tetraodon nigroviridis
XP_789228 158 ELDKEELRKLVSSLETANRAVLQL 181 purple urchin
EAT33795  161 EMNRERLADMIEVLEKCDGMDVDK 184 yellow fever mosquito
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