2Z1D


Conserved Protein Domain Family
HypD

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pfam01924: HypD 
Hydrogenase formation hypA family
HypD is involved in hydrogenase formation. It contains many possible metal binding residues, which may bind to nickel. Transposon Tn5 insertions into hypD resulted in R. leguminosarum mutants that lacked any hydrogenase activity in symbiosis with peas.
Statistics
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PSSM-Id: 460385
Aligned: 276 rows
Threshold Bit Score: 471.1
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2Z1D_A              12 EVAMKLVEKIREEAKTlDGEIRIMHVXGTHEDTVTRHGIRSLLPENVKVVSGPGCPVCITPVEDIVAMQLIMRKareege 91  Thermococ...
jgi:Ddes_0801       11 QLCHSLLDRLNRALDG--RPMRFMEVCGTHTVAIFQSGLRSLLPSAVAHLSGPGCPVCVTHDAEVAAFLDLAGRd----- 83 
Q316I1              11 vlCRGLLDRLRAETDA---PLRFMEVCGTHTVAIFQSGLRPLLPEQVVHVSGPGCPVCVTHESEIAAYLELAERd----- 82  Desulfovi...
Q72F89              13 ALCRGLLDRLHRELDR---PLRFMEVCGTHTVAIFQSGIRPLLPEGVRHLSGPGCPVCVTHESEVAAYLQLAERg----- 84  Desulfovi...
jgi:Dret_1076       12 QLCQALVRDLQQRIGD---GFRFMEVCGTHTVSIFQSGLRSLLPDNLTHLSGPGCPVCVTHEREVAAFLDLARQp----- 83 
gigasnome:DGI_1098  16 ALARSLVQAIERECAE---PLTFMEVCGTHTVAIFRSGIHSILPETVVHLSGPGCPVCVTHEQEVELFLQIAARp----- 87 
ESQ09464             4 qadealLARLSTLI---DRPVRVMVVCGTQIRTILKFGISEMVPEQLELVPGPGCSVCVMPEGHIDAYVKIAMQp----- 75 
Q6API1               8 pspeALLEELHRVV---SKPIRLMVVCGTHNRAILRYGIREELPDFIELVAGPGCSVCVMPTGHVDAFVKVARQp----- 79  Desulfota...
WP_015403423        11 TLAEPLLKELRRSVTK---PFRVMEVCGTHTMSIFRSGLRTLLPEEIELISGPGCPVCVTSASHIDAILAMAELq----- 82  Desulfoca...
Q6AQR5              11 KLAKPLVAELRRSVTK---PLRIMEVCGSHTMSIFRNGIRSILPEGMELLSGPGCPVCVTSAAHMDAFISIAERd----- 82  Desulfota...
2Z1D_A              92 EIILTTFGDMYKIPTPM-GSFADLKSEGF-DVRIVYGIFDTYRIAKENpDKTVVHFSPGFETTTAPAAGMLNVaaQEELE 169 Thermococ...
jgi:Ddes_0801       84 RVIVATFGDLLRVPGPDgRSLKHAQAQGA-RVEIVYSPLDALSLAAENpGDTVVFLGIGFETTAPTVAATLLTarQRRLD 162
Q316I1              83 KVIIATFGDLMRVPGPGgKTLKSAQAAGA-RIEVVYSPVDALSLAAAHpQSTVVFLGIGFETTTPAVAATIKTadRQGLK 161 Desulfovi...
Q72F89              85 DVIIATFGDLMRVPGPGgRNLKLAQAQGA-RIEVVYSSFDALKLAADNpGEKVVFLGIGFETTAPTVAGTVQMarAQGLD 163 Desulfovi...
jgi:Dret_1076       84 GVVVATFGDLLRVPGPEgRSLKAAQAEGA-QVEVVYSPFDALQLAQDRpGKHIVFLGIGFETTAPTVAATLKTakRDALS 162
gigasnome:DGI_1098  88 DAIVATFGDLMRVPGMQgQSLKTAQAEGA-RVEVVYAPFDALDLARANpDKQVVFLGVGFETTAPAIAATMQMakAQGLG 166
ESQ09464            76 DVITATCDDLLRVPGST-SSLEELRDAGV-WVEVVDAPMEALDLARRYpDKIVVFTAVGFEGAAPDVAEAILEaaSEGIE 153
Q6API1              80 DVITATCEDLLKVRGSK-ESLADVLNEGVhRVEIISSPRQALELAYVEeDKIVVYPAVGFEATAPSIAETILEaaQNGVG 158 Desulfota...
WP_015403423        83 NTRIALFGDLFRVPGSNgLSLANASSQGA-KVDIVYSPMDSLNLARKYpEELIVFLGVGFETTTPGIAATILAakNSALD 161 Desulfoca...
Q6AQR5              83 GVRVAIFGDLFRVPGSQ-GSLANASSRGA-KVDIVYSPMDALEIAKNNpDELVVFLGVGFETTTPTIAATIMAakIQKIK 160 Desulfota...
2Z1D_A             170 NFKIYSVHRLTPPAVEVLLKQG-TVFQGLIAPGHVSTIIGVKGWEYLTEKYGIPQVVAGFEPNDVLMAILMLIRMYK--- 245 Thermococ...
jgi:Ddes_0801      163 NFCVLSLHKLVPPALRALLDDSqCAVEAFLLPGHVSTILGLQPYDFLAKDYGVPGVVGGFQPADILLALCMMAEQLR--- 239
Q316I1             162 NFQVLSFHKLVPPALGALLSDPdCAVDAFLLPGHVSTILGTAPYNFVAEQFHTPGVVAGFDPADILQALLLMVQMRR--- 238 Desulfovi...
Q72F89             164 NFMVLSFHKLVPPALRALLVDPeCAVDAFLLPGHVSTVLGIEPYRFVATEFGTPGVIAGFDPVDILQALLIMVEQRK--- 240 Desulfovi...
jgi:Dret_1076      163 NFSVLSLHKLVPPALQALMDDTaCAIDGFLLPGHVSAVIGTQPYAFVAEKYRTPGAVAGFEPVDILAGLQELLRQRE--- 239
gigasnome:DGI_1098 167 NFLVLSMHKLVPPALKALLDDDsARVDAFMLPGHVSLVLGLAPYQFIARDYGIPAVVAGFEPLDILAALLTLARQRNair 246
ESQ09464           154 NFCVIPSIRLLPPSLDNLFKDPeLNIRGLLCSAHVEAITDTEAYAQLARRHHLACAVTGFGVNDILKGLITIVDQLR--- 230
Q6API1             159 NFCVIPSIRLLPPTIDALLLDPqLSIQGLLCSDHINTISDTEAYADLARKHSLSCCIAGFEKAEILQGILSMVKQIH--- 235 Desulfota...
WP_015403423       162 NFAVFSTHKTMPPPLLALLDDPeLQIDGLLCPGHVSSIIGAGAYQPLADTYKLACVVGGFEPADILQALILMARQIA--- 238 Desulfoca...
Q6AQR5             161 NFAVFSTQKTMPAPLIALLQDPeLKIDGLLCPGHVSAIIGSEVYEPLARDYNLACVVAGFETADILGSLIQLARQVN--- 237 Desulfota...
2Z1D_A             246 EGE-ARIINEYERAVKYEGNVVAQKMIDKFFEVVDAKWRALGVFPKSGLELRKEWKDFEIRSFYKVEvPKNLPDLEKGCR 324 Thermococ...
jgi:Ddes_0801      240 DKT-PAVVNAYPRAVDDTGNPRARALLEQFFTPADALWRGIGSIPHSGLVLRAEYEDMDAMKRLGLTl--PDVPPLAGCR 316
Q316I1             239 RGE-YAITNQYSRAVSDNGNPKARSIMYEVFRPADALWRGIGTIPDSGLVFTDAYRQFDAMEQQELTl--RDVPNTPGCR 315 Desulfovi...
Q72F89             241 TGE-YGIVNAYRRAVDDAGNPRARQVMDDVFMQSDALWRGIGLLPGSGLVFRPEYARFDAMQRLGLTl--PEARDTPGCK 317 Desulfovi...
jgi:Dret_1076      240 AGE-PSIANVYPRVVGDQGNAKAMALMEEVFAPCDTLWRGLGELPGSGLEIRSAFADHDARQVLGIEw--PEVPPLPGCR 316
gigasnome:DGI_1098 247 QGAaAEIINDYPRAVSEHGNPKARAVMDEVFTVVDARWRGLGVIPQSGLAIAEAYADQDAMRVLGLTm--PEPRTLPGCK 324
ESQ09464           231 SAQ-PDRDNPFAGITSNAETTRVQKMLSEVFFATDSDWRGLGSIAGSGFVIRDELSLYDATKRFNI--RIQQGEEPLECR 307
Q6API1             236 RGE-SMVDASGAMVYSMEETARARRVVEEVFFPTETAWRGLGSIAESGFVIRDELALYDATKRFNV--RFAEGTDQCMCH 312 Desulfota...
WP_015403423       239 NGE-ARVENAYTRAVRWEENSRAQQMVRAIFKTADMEWRGLGVIPESGLAIREEYSHYDAERRLNIKl--TPATEPKGCR 315 Desulfoca...
Q6AQR5             238 AGE-FKVENCYNRVVCKDGNPRARAMVERIFEPCDMQWRGLGMIPESGLKIREEYGEFDAERRLEIEl--TEVAEPKGCL 314 Desulfota...
2Z1D_A             325 CGAVLRGLALPTDCPLFGKTCTPRHPVGPCMVSYEGTCQIFYK 367 Thermococcus kodakarensis KOD1
jgi:Ddes_0801      317 CGDVLKGRITPPACPLFGKKCTPATPVGPCMVSTEGSCAAYFK 359
Q316I1             316 CGDVLKGKMQPDNCPLFAKACTPARPVGPCMVSTEGSCAAYFK 358 Desulfovibrio alaskensis G20
Q72F89             318 CGDVLKGKMQPNECPLFGKACVPAKPVGPCMVSTEGSCAAYYK 360 Desulfovibrio vulgaris str. Hildenborough
jgi:Dret_1076      317 CGDVLKGKLSPEQCPLFGTRCTPATAVGPCMVSTEGSCAAYYK 359
gigasnome:DGI_1098 325 CGDVLKGKIRPDQCPLFKKACTPANPVGPCMVSTEGSCAAYYK 367
ESQ09464           308 CAEIISGKCLPTECPAFGISCSTRNPIGPCMVAQEGICASYLR 350
Q6API1             313 CNEIISGRALPPDCPAFGMACTLQNPVGPCMISNEGICAAYFK 355 Desulfotalea psychrophila
WP_015403423       316 CGEILKGKEVPSQCPLYGKRCTPGNPVGPCMVSSEGTCAAFFK 358 Desulfocapsa sulfexigens
Q6AQR5             315 CGEILKGQTIPPRCPLFNKGCTPMNPVGPCMVSSEGTCAAYYK 357 Desulfotalea psychrophila
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