Conserved Protein Domain Family
SLC5sbd_SGLT5

?
cd11489: SLC5sbd_SGLT5 
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain
Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Statistics
?
PSSM-Id: 212058
Aligned: 4 rows
Threshold Bit Score: 1039.52
Created: 18-Jul-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on site mutagenesis and examination of partial transcripts of rabbit SGLT1
  • Citation:PMID 1903656
  • Comment:predicted for bovine SGLT5

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
AAH34380      12 SVADIIVITVYFALNVAVGIWSSCRaSRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWN 91  human
XP_001345853  17 SVSDIIVIGAYFLLNVAVGIWSSCRvSRNTLSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAGFEWN 96  zebrafish
Q6R4Q5        18 TVVDIAIIAVYFALNVAVGIWSSCRaSRNTVRGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWN 97  cattle
XP_001233919  17 SVADLVVIVTYFSLNLAVGIWSSCRvNRNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVTGFEWN 96  chicken
Feature 1                                                                                        
AAH34380      92 ATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGqRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILT 171 human
XP_001345853  97 ATYALLALAWVFVPVYVSSGIVTMPEYLGRRFGGeRIRMYLSALSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLM 176 zebrafish
Q6R4Q5        98 ATYVLLALAWVFVPIYLSSEIVTMPEYMQKRYGGqRIRMYLSVLSLLLSVFTKISIDLYAGALFVHICLGWNFYLSTVIM 177 cattle
XP_001233919  97 ATYALLALAWVFVPVYISSGIVTMPEYLQRRFGGeRIRMYLSGLSLLLSIFTKISTDLYSGALFVQVCLGWNLYLSTVLM 176 chicken
Feature 1                                                                      #                 
AAH34380     172 LGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYgqLEAAYAQAIPSRTIaNTTCHLPRTDAMHMFRDP 251 human
XP_001345853 177 LVVTALYTIAGGLAAVIYTDTLQTFIMIIGAVILTITAFNKIGGYsnLESVYLQAVPSKIIpNTTCHLPRHDAMHLFRDP 256 zebrafish
Q6R4Q5       178 LAITALYTIAGGLTAVIYTDALQTLVMVAGAVILTIKAFEQIGGYeqLAEAYAQAVPSRTIsNTTCHVPRADAMHMFRDP 257 cattle
XP_001233919 177 LLVTGLYTIAGGLVAVIYTDALQTLIMVLGAIVLAVKAFNAIGGYsnLEEAYLKAVPSKIVpNTTCHLPRADAMHLFRDP 256 chicken
Feature 1                                                                                        
AAH34380     252 HTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLnHAKAGSILASYLKMLPMGLIIMPGMISRALFPDDVGCVVPS 331 human
XP_001345853 257 VHGDLPWPGMTLGLTIIATWYWCTDQVIVQRSLSAKSLsHAKGASIFASYLKLLPMMFIILPGMISRALYPDTVACVDPE 336 zebrafish
Q6R4Q5       258 YTADLPWTGMTFGLTIMAAWYWCTDQVIVQRSLSARDLnHAKGGSILASYLKMLPMGLMVMPGMISRVLFPDDVGCVVPA 337 cattle
XP_001233919 257 ISGDLPWTGMTFGLSIMATWYWCTDQVIVQRSLSARSLsHAKAGSILASYLKMLPLFVIIMPGMISRVLFPDAVACVDPE 336 chicken
Feature 1                                                                                        
AAH34380     332 ECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRsgERELLLVGRLV 411 human
XP_001345853 337 ECVKVCGAEVGCSNIAFPKLVIELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWKKYRRGasEKELLLVGRIV 416 zebrafish
Q6R4Q5       338 ECLRACGAEIGCSNIAYPKLVMELMPTGLRGLMVAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPRagERELLLVGRLV 417 cattle
XP_001233919 337 ECTRVCGAAVGCSNIAYPKLVVELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRMRPGasERELLMVGRVV 416 chicken
Feature 1                                                                                        
AAH34380     412 IVALIGVSVAWIPVLQdsNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAP 491 human
XP_001345853 417 TVILVVISVVWIPILQsaNSGQLYVYIQSVTSYLAPPVTAIFVMAVFWKRTNEAGAFWGLMVGLVVGLTRMVLEFAFPPP 496 zebrafish
Q6R4Q5       418 IVVLVGVSVAWIPVLQgsNGGQLFIYMQSVTSSLAPPVTAVFVLGIFWRRANEQGAFWGLMAGLAVGATRLVLEFLHPAP 497 cattle
XP_001233919 417 TVLLVALSVVWIPILQssGGGQLYIYIQAVTSYLAPPVTAVFILAVFWPRANEQGAFWGLMAGLALGLARMGLELAHPTP 496 chicken
Feature 1                                                                                        
AAH34380     492 PCGEPDTRPaVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKagdgq----------- 560 human
XP_001345853 497 RCGVFDPAPsVLRSMHYLHFAIILCALTAIVVAVISLLTPPPTEEQTRNLTWWTLHNSTEREIPlqkvstlsrrtdgces 576 zebrafish
Q6R4Q5       498 PCGHPDTRPpILHGVHYLHFAVALFLLSGAVVVAGSLLTPHPQGVQIQSLTWWTLAQDLPLGVKtgdgr----------- 566 cattle
XP_001233919 497 RCGVPDRRPwLLADLHYLHFAALLCATAGAVVVGGSLMTPPPPSDRLRNHTWWSLSQEPPQHSMdgtsqryldgscaaap 576 chicken
Feature 1                                                                     
AAH34380     561 ------------------------------tpqkhAFWARVCGFNAILLMCVNIFFYAYFA 591 human
XP_001345853 577 vrrgkcvrtagfcsprpgrfasgtpppiihsttedPFWSRFCCVNAIILMCVNIFLYAYYA 637 zebrafish
Q6R4Q5       567 ------------------------------asqrhAFWARVCGVNAILLMCVNIFFYTYFA 597 cattle
XP_001233919 577 d-----------------swqtteglpalrdttesPFWTRVCSINAIVLLCINIFCYAYFA 620 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap