Conserved Protein Domain Family
Pinin_SDK_memA

?
pfam04696: Pinin_SDK_memA 
pinin/SDK/memA/ protein conserved region
Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.
Statistics
?
PSSM-Id: 461396
Aligned: 89 rows
Threshold Bit Score: 64.2357
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002501619 108 EGEKRRGRRMLAGLLGTLKRHRD-EEKAVA----AvtaQRRSVIEQAETKAREVSEKL----R---QE---SFASNALRR 172
EMR11784      37 lDEQKRGQRFLGTLMGTLGKFQKeSVFLQEk--nA---KRAEIEARLAECMRKEKEALeeraRi--EQdekQRAAERLRR 109
XP_018228689  44 SDDQKRAQRFLGTLMGTLGKFQKeSAFLQEk--nA---KRAEIEARLAECMRKEKEEIeervRt--EQdekYRRAERQRR 116
KLU83950     148 TEEKKRGQRFFRGLLSSLNREPR-AA-QQK--------HRDEIERRQKEKAEQRRVADekrkAaegERrkkLARLEPIRK 217
XP_009226151 126 AEEKQRGKRFFRGLLSSLNREPR-AA-QKK--------HRDEIERRQKEKAEQRKAAEeerkAveeERkknLARLEPIRK 195
ENH77915      76 DEEKKRGRRLFGGLLSTLSQTTA-ST-QQR--------KRREIEQRQQERVQKERAEDekrkS---EK---LAKVQEVKL 139
EQB55465      86 EEEKKRGKRLFGGLLSTLSQTNT-SS-QHK--------KRREVEQRQQERAQKQRVEDdkrrA---EK---LARITEVRW 149
OBR14329      98 DEEKKRGKRLFGGLLSTLSQTNA-SS-QHK--------RRREIEQRQHERAQKQRAEDdkrrT---EK---LARITEARW 161
EPY50211      53 pTENKRSKRMFGALLGTLGKFQKeAEREKQsetrV---RRAELEKKLAKRQEEERKELdiqeSq--EQeqrEKDLAQERR 127
Q10492        67 SVEQKRGRRMFGALLGTLGKFQQeSEREQKsarkV---KRAELEEKLAKRREQELQELekqeKi--EAeilESRLQEQRK 141 Schizosaccharom...
XP_002501619 173 ARDHRRtaeidlrvaEKELevkraARLEKDAKTAGCA--RTSKEcgrPRVFYRPKAHTKDTEAAVEVT 238
EMR11784     110 ASLREF---------EKLS-----LETYYKNEMASARalKTTTL---PVLFYQPWKLSSKEEERAKIR 160
XP_018228689 117 ENLREF---------ERMS-----LETFYKNEIAAAHslKTVTS---PVLFYLPWKLSPKEEEKVRMR 167
KLU83950     218 AEQIEF---------DQRA-----MRTRHSNLVAQAYslKTKSG---PPIYFQPWEMTKKQEDTVDRQ 268
XP_009226151 196 AEQIGF---------EERA-----MRTRHSNIMAQAHslKTRSG---PPIYFRPWEMTRKQEDAVGRQ 246
ENH77915     140 KEQIYV---------DERV-----MRARHRNLLAKAHslQTKEK---PHIFYRPWKLTKDQEDTIGDQ 190
EQB55465     150 QEQIKF---------DEKV-----MRTRHSNMLAMAHslRTKTQ---PQIFFRPWKLTREQEDEIDDQ 200
OBR14329     162 REQIKL---------DEKA-----MKTRHVNMLAMAHslRSKAK---PPVYYRPWKLTSEQEDRIDGQ 212
EPY50211     128 VAMEDL---------ELDL-----KDLKQTLKKQESTflKTNTE---PRLYYRPYYLLPSQKEYLDQV 178
Q10492       142 VALDEL---------ELDR-----NDLKKVLDNKKSYylRTKTQ---PSLFYRPYYLLPSQRTQLEQM 192 Schizosaccharomyces pombe 9...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap