3ZPV


Conserved Protein Domain Family
PHD_dPYGO
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cd15637: PHD_dPYGO 
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PHD finger found in Drosophila melanogaster protein pygopus (dPYGO) and similar proteins
dPYGO, also termed protein gammy legs, is a nuclear adapter protein encoded by pygopus (pygo). It is a fundamental Wnt signaling transcriptional component in Drosophila, and has both Wnt-related and Wnt-independent functions. It plays a critical role in aging-related cardiac dysfunction that is canonical Wnt signaling independent. dPYGO contains a plant homeodomain (PHD) finger, which is important for Lgs/Bcl9 recognition as well as for the regulation of the Wnt/beta-catenin signaling pathway.
Links
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Statistics
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PSSM-Id: 277107
Aligned: 5 rows
Threshold Bit Score: 90.6978
Created: 19-Dec-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteH3K4me bindingBCL9 HD1
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #            #   #    #  #                    #  #
3ZPV_A         7 PCGMCHKEVNDNDEAVFCEsGCNFFFHRTCVGLTEAAFQMLNKEVFAEWCCDKC 60  fruit fly
ELU05409     220 PCGYCHKEVHDNDQAILCEsGCNFWFHRVCTGLTEPAYLMLTKEVYAEWACDKC 273 Capitella sp. I Grassle & Grassle, 1976
XP_002413030 148 PCGVCHKEVHDNDQAILCEsGCNFWFHRICTGLTDAAFHLLTQEVYAEWVCDRC 201 black-legged tick
AEH58052      92 PCGKCHREIHDNDQAIQCYrGCKFWFHRTCVGLLEEAWHMVINEPYAEWVCDSC 145 Trichinella spiralis
ESO89625       4 PCGICHKEVHENDQGILCEsGCNFWFHRTCTGLTEPAFKMLTQAIYAEWVCDKC 57  owl limpet

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