5TIK


Conserved Protein Domain Family
CyRPA
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pfam18638: CyRPA 
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Cysteine-Rich Protective Antigen 6 bladed domain
Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a 42.8 kDa protein of 362 residues with a predicted N-terminal secretion signal. It is part of a multi-protein complex including the PfRH5-interacting protein PfRipr and the reticulocyte binding-like homologous protein PfRH5, which binds to the erythrocyte receptor basigin. PfRH5, PfCyRPA, and PfRipr colocalize during parasite invasion at the junction between merozoites and erythrocytes. The complex seems to be required both for triggering Ca2+ release and establishment of tight junctions. PfCyRPA adopts a 6-bladed beta-propeller structure with similarity to the classic sialidase fold, but it has no sialidase activity and fulfills a purely non-enzymatic function. Each blade of the propeller is constructed by a four-stranded anti-parallel beta-sheet.
Links
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Statistics
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PSSM-Id: 408420
Aligned: 4 rows
Threshold Bit Score: 432.307
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5TIK_D        12 LSFIKNNVPCIRDMFFIYKRELYNICLDDLKGEEDETHIYVQKKVKDS--WITLNDLFKETDLTGRPHIFAYVDVEEIII 89  Plasmodium falc...
1_pfamImport   1 ITTITSPVHCIADTYFIFRNELYKICIQHVNKGRTEIHVIVQKKAKNK--WETKQKLFEDKMWFHLPFVFNFVQNDEIII 78 
XP_001615140  37 ITTIKSPIHCITDIYFLFRNELYKTCIQHVIKGRTEIHVLVQKKINST--WETQTTLFKDHMWFELPSVFNFIHNDEIII 114
2_pfamImport   1 ISKDTNMKQCYSEHFVNFKGEIVQVCLDKVPYGSLNKYNILISSYGEDkkWTMQSKALDNYTTKLLKYFYSFTNNEQLVV 80 

5TIK_D        90 LLCEDEEFSnRKKDMTCHRFYSNDGKEYNNAEITISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKDDNKKDDI 169 Plasmodium falc...
1_pfamImport  79 LVCRYKGMT-KGEGVACDRWSSTTGTNYNKGNINIDAQALTKMNLDSYASFPIPIKDKAIIHICGVHSYEYQNVNQNNFI 157
XP_001615140 115 VICRYKQRS-KREGTICKRWNSVTGTIYQKEDVQIDKEAFANKNLESYQSVPLTVKNKKFLLICGILSYEYKTANKDNFI 193
2_pfamImport  81 VFCFNKNLS--NPPYECYRSITNDLKTLKTEKIQIDLRMFEPSSFNDYALNSFDLFGVGHFLICGINNKRNSKPNVGLLV 158

5TIK_D       170 LCMASHDKGETWG-TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE------KDLEFVC 241 Plasmodium falc...
1_pfamImport 158 SCLASEDKGTTWGdIKIHIYYDQFQEGVPYFYLRPLVFNDEFGFYLYSRIsSNNADRGGKYMKCILNptnsrnKEYTFKC 237
XP_001615140 194 SCVASEDKGRTWG-TKILINYEELQKGVPYFYLRPIIFGDEFGFYFYSRIsTNNTARGGNYMTCTLDvtnegkKEYKFKC 272
2_pfamImport 159 ICHASADGGFTWK-KKLNFYHPNMDKNTTYESLVPKISGNEIGFQYLASKvSLTK-----YFKCYYK------KDHDFEC 226

5TIK_D       242 SNRDFLKDNKVLQDVSTLNDEYIVSYGNDNNFAECYIFFNNENSILIKPEKYGNTAAGCYGGTFVKIDENRALFIYSSSQ 321 Plasmodium falc...
1_pfamImport 238 TNVNLIKEDKSLQNITKLNGYYVTSYAKKNNFNECYLYYTENNAIVVKPKVQNYELNGCYGGSFVKFNESKALFIYSTGH 317
XP_001615140 273 KHVSLIKPDKSLQNVTKLNGYYITSYVKKDNFNECYLYYTEQNAIVVKPKVQNDDLNGCYGGSFVKLDESKALFIYSTGY 352
2_pfamImport 227 QDVNMVREQSYIWDIAKIRGYYVSPIS-DGKAPPTQLYYMYKNTYLMPIEVPKSIGTEYNRGKVFQLDNQKLIYSYANEK 305

5TIK_D       322 GIYNI 326 Plasmodium falciparum 3D7
1_pfamImport 318 GVQNI 322
XP_001615140 353 GVQNI 357
2_pfamImport 306 EAYTY 310
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