Conserved Protein Domain Family
DsbA_Com1_like

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cd03023: DsbA_Com1_like 
DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC motif, assumed to be imbedded in a DsbA-like structure. Its homology to DsbA suggests that the protein is a protein disulfide oxidoreductase. The role of such a protein in pathogenesis is unknown.
Statistics
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PSSM-Id: 239321
Aligned: 39 rows
Threshold Bit Score: 144.273
Created: 22-Dec-2004
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
catalytic
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:based on known function of DsbA
  • Comment:CXXC motif
  • Citation:PMID 9655827

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #  #                                                            
BAA20499   91 GNPHGNVTLVEFFDYQCGHCKAMNSVIqa-iaKQNKNLRVVFKELPIFGGQs----QYAAKVSLAAa--kQGKYYAFHDA 163 Coxiella burnetii
AAV88815  100 GAEKGRVTIVEFSDYACGFCRKANGDLnr-llSEDKDIRLVIRQLPILGPDs----EIAARTALAIak-nSSKFSEFHHQ 173 Zymomonas mobilis ...
NP_420686  87 INPAGTITVTEFFDYRCGYCRQATPAVle-lvQKNPDIRLVLKDFVIFGNDs----EAAARIALGAk--dQGKSLELHKA 159 Caulobacter cresce...
NP_801125  81 GAETPELTIINVTDYSCPFCKRLEGELvk-vgKEYPQIKVLNLNVSFKEQYek-ngYNSASYALNVwqnqRDKYEQVHEL 158 Vibrio parahaemoly...
NP_946373  52 GNPKGDITIVEWSDYRCPYCKKVAPDLtq-vvKEDGNIRLVLKDWPIFGGVs----VDAAKMVLASk--yQGKFLQAHEA 124 Rhodopseudomonas p...
YP_067376 106 GNQNGDITIIAFYDYNCSFCKKGDISIne-llQNDQKVKVVLRPLPILGDAs----EYLARIVLAVykvnPNKFKVIHDA 180 Rickettsia typhi s...
YP_154603  84 GDQDAPHKIIVFTDYNCPFCKKLEPGLhk-liEEYPSIQVVNIFVPLRQQQvdglkTNSALYGLNLwrndPKAFFEAHNL 162 Idiomarina loihien...
YP_130349  87 GSENPKLTIINFTDFNCPYCKRLDPVLqr-ltEENQEVRVVNVFVPLQQREvagidTNSAQYALNVwkndPDGYMKVHDY 165 Photobacterium pro...
YP_205875  82 GAKDPKLTIVVLTDLSCPWCKKLDPVLmklveEHPDDLKVINIYVPLKEGSn---pANSATFALRVwkesPDKFNKISET 158 Vibrio fischeri ES114
YP_191931  95 GNPHGRITVVEFYDPRCSYCRSMMGEVds-flSRHPDVRLVEKVVPVLGTNsv--lDTRAIFAASA----QGKYEAMRRA 167 Gluconobacter oxyd...
Feature 1                                                                                     
BAA20499  164 LLSVDgqLSEQITLQtaEKVGLNVAQLKKDmdn--paIQKQLRDNFQLAQSLQLAGTPTFVIGnkaltkFGFIPGATsqq 241 Coxiella burnetii
AAV88815  174 IYNSKh-LSPEVIVDivKSLGLNPQDIAKQgsd--paITQEITKNILLARELGLTGTPAFIIG------DKVFSGVAgyd 244 Zymomonas mobilis ...
NP_420686 160 LMAENa-LDARGALRiaERLGIDMDKAKAVges--qaITQHLADTDALARALNLSGTPAFIVG------DTLVPGADi-d 229 Caulobacter cresce...
NP_801125 159 LVKKPgaHDARSLKQi-AKKTGTEAQLVDDk-----eTKALLDKNYQYFTQLGLRGTPALIIN------DQVIPGYVpfd 226 Vibrio parahaemoly...
NP_946373 125 LIGSTskLTETTLTEtlKAGGIDVDRATKDldanratIEAILKRNDTQAKAFGFQGTPSFIVG------RFRVPGVLdva 198 Rhodopseudomonas p...
YP_067376 181 LIKIRt-ASQESIKEllIEHGLNSTEIEKIads--neIKDLITQNIKIARSLRMQGVPTYIID------SKLIHGLIdlp 251 Rickettsia typhi s...
YP_154603 163 MMKKSgmHTADSLQSv-AQVTSTEAFLSPSg-----eSEAVIRKNMSAFRDLGFRGTPTIIIG------QQVMPGYIp-y 229 Idiomarina loihien...
YP_130349 166 LIRKNgrHDKSSLER--VAQVTNTKMLLDAsn----tLKPTVDKSYQVFSELGLNGTPAMLIG------DQILPGYLpyd 233 Photobacterium pro...
YP_205875 159 LLSKPgiHNTRSIMKv-AKANDAEKYVSTNd-----eVQDMVAKNYQLFTDLGVRGTPAMLID------GQLLPGYLpye 226 Vibrio fischeri ES114
YP_191931 168 LMADTtkPSMERIVElaQANGIDTKKLTADmss--pqTVALINTNLDQGRAVGLDGTPTFIFGt-----AAVAPGALe-a 239 Gluconobacter oxyd...
Feature 1            
BAA20499  242 NLQKEID 248 Coxiella burnetii
AAV88815  245 ALKEAVA 251 Zymomonas mobilis subsp. mobilis ZM4
NP_420686 230 ALKLAIE 236 Caulobacter crescentus CB15
NP_801125 227 ELEKVID 233 Vibrio parahaemolyticus RIMD 2210633
NP_946373 199 LFKQAIK 205 Rhodopseudomonas palustris CGA009
YP_067376 252 QLLNLVK 258 Rickettsia typhi str. Wilmington
YP_154603 230 DKLEEIA 236 Idiomarina loihiensis L2TR
YP_130349 234 QLKPIVE 240 Photobacterium profundum SS9
YP_205875 227 KLAPMVE 233 Vibrio fischeri ES114
YP_191931 240 DQMDAFL 246 Gluconobacter oxydans 621H

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