Conserved Protein Domain Family
Zn-C2H2_spn-F
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cd21971: Zn-C2H2_spn-F 
C2H2-type zinc binding domain found in Drosophila melanogaster Spindle-F (Spn-F) and similar proteins
spn-F is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. It acts downstream of IKK-related kinase Ik2 in the same pathway for dendrite pruning. Spn-F is a coil-coiled protein containing a C2H2-type zinc binding domain.
Links
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Statistics
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PSSM-Id: 412017
Aligned: 5 rows
Threshold Bit Score: 49.8318
Created: 8-Jun-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that Homo sapiens CALCOCO2 (2MXP) binds a Zn2+ ion through its C2H2-type zinc binding domain.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #               #   #   
NP_001263138 310 EKTCPMCGKQYSSqVSFNAFREHVEMHFID 339 fruit fly
NP_651858    310 EKTCPMCGKQYSSqVSFNAFREHVEMHFID 339 fruit fly
XP_007902549 582 HLECPMCHKIFID-APQHEFNEHVQNHFKV 610 elephant shark
ELT98218     431 NRVCPMCNEQFSDsVTDRDFHEHVDRHFDT 460 Capitella teleta
CBY38647     182 ERKCPVCSYYFPN-LSVHEFQEHVETHFED 210 Oikopleura dioica

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